A5073676650- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Myocardial Infarction Research
- Cardiac and Coronary Surgery Techniques
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Lipoproteins and Cardiovascular Health
- Cardiomyopathy and Myosin Studies
- Health Systems, Economic Evaluations, Quality of Life
- Peripheral Artery Disease Management
- Atherosclerosis and Cardiovascular Diseases
- Congenital Heart Disease Studies
- Blood Pressure and Hypertension Studies
- Atrial Fibrillation Management and Outcomes
- Infective Endocarditis Diagnosis and Management
- Healthcare Policy and Management
- Cardiovascular Disease and Adiposity
- Health and Medical Research Impacts
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
Mayo Clinic in Arizona
2014-2024
Nevada National Security Site
2024
Mayo Clinic
2012-2021
Mayo Clinic in Florida
1999-2021
WinnMed
1992-2019
American College of Cardiology
1991-2018
BG University Hospital Bergmannsheil Bochum
2018
Palo Alto Institute
2018
Beskyd Fryčovice (Czechia)
1978-2015
Nieuwegein Fonds
2015
From 1950 to 1980, 3623 patients from Olmsted County, Minnesota, were found have atrial fibrillation. Ninety-seven of these (2.7 percent), who 60 years old or younger at diagnosis, had lone fibrillation (atrial in the absence overt cardiovascular disease precipitating illness), and their data reviewed determine incidence thromboemboli. Twenty (21 percent) an isolated episode fibrillation, 56 (58 recurrent 21 (22 chronic The total follow-up period was 1440 person-years, with a mean 14.8 per...
Background Mitral valve repair has been suggested as providing a better postoperative outcome than replacement for mitral regurgitation, but this impression obscured by differences in baseline characteristics and not confirmed multivariate analyses. Methods Results The outcomes 195 patients with 214 organic regurgitation were compared using analysis. All had preoperative echocardiographic assessment of left ventricular function. Before surgery, less symptomatic those (42% New York Heart...
Mitral regurgitation due to flail leaflet is difficult manage, because it frequently asymptomatic yet carries a high risk of left ventricular dysfunction and the natural history condition poorly defined.We obtained clinical follow-up data through 1994-1995 in 229 patients with isolated mitral leaflet; this was first diagnosed by echocardiography between 1980 1989.The 86 who were treated medically had mortality rate significantly higher than expected (6.3 percent yearly, P=0.016 for...
IntroductionAtrial fibrillation (AF), the most common sustained cardiac rhythm disturbance, is increasing in prevalence as popu-lation ages.Although it often associated with heart disease, AF occurs many patients no detectable disease.Hemodynamic impairment and thromboembolic events result This document was
Left ventricular dysfunction is a frequent cause of death after successful surgical repair mitral regurgitation. The role preoperative echocardiographic left variables in the prediction postoperative survival and thus their clinical implications remain uncertain.The 409 patients operated on between 1980 1989 for pure, isolated, organic regurgitation with echocardiogram (within 6 months operation) was analyzed. overall 75% at 5 years (90% expected), 58% 10 (88% 44% 12 (73% expected)....
To prevent occlusion of aortocoronary-artery-bypass grafts, we conducted a prospective, randomized-double-blind trial comparing dipyridamole (instituted two days before operation) plus aspirin (added seven hours after with placebo in 407 patients. Vein-graft angiography was performed 360 patients (88 per cent) within six months operation (median, eight days). Within one month operation, 3 cent vein-graft distal anastomoses (10 351) were occluded the treated patients, and 10 (38 362) group;...
Background —Unstable angina (UA) is associated with systemic inflammation and expansion of interferon-γ–producing T lymphocytes. The cause T-cell activation the precise role activated cells in plaque instability are not understood. Methods Results —Peripheral blood from 34 patients stable UA were compared for distribution functional subsets by flow cytometric analysis. Clonality within compartment was identified receptor spectrotyping subsequent sequencing. Tissue-infiltrating examined...
To study the prevention of occlusion aortocoronary-artery bypass grafts, we conducted a prospective, randomized, double-blind trial comparing long-term administration dipyridamole (begun two days before operation) plus aspirin seven hours after with placebo in 407 patients. Results at one month1 showed reduction rate graft patients receiving and aspirin. At vein-graft angiography performed 343 (84 per cent) 11 to 18 months (median, 12 months) operation, cent 478 distal anastomoses were...
Background —Surgical correction of mitral regurgitation in patients with no or mild symptoms remains controversial, particularly because the impact preoperative on postoperative outcome is unknown. Methods and Results —The long-term 478 organic (199 NYHA functional class I/II 279 III/IV before surgery) operated between 1984 1991 was analyzed. In surgery compared those III/IV, survival higher (at 10 years, 76±5% versus 48±4%, P <0.0001), lower operative mortality (0.5% 5.4%, =0.003) better...
Monocytes are constitutively activated in unstable angina (UA), resulting the production of IL-6 and upregulation acute phase proteins. Underlying mechanisms not understood. To explore whether potent monocyte activator IFN-gamma is altered UA, we compared cytokine by T lymphocytes patients with UA (Braunwald's class IIIB) stable (SA).Peripheral blood were collected at time hospitalization after 2 12 weeks. Cytokine-producing CD4(+) CD8(+) cells quantified 3-color flow cytometry stimulation...
The Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial in 2368 patients with stable ischemic heart disease assigned before randomization to percutaneous coronary intervention or artery bypass grafting strata reported similar 5-year all-cause mortality rates insulin sensitization versus provision therapy and a strategy of prompt initial revascularization intensive medical alone reserved for clinical indication(s). In this report, we examine the predefined secondary...
Cardiac troponin concentrations are used to identify patients who would benefit from urgent revascularization for acute coronary syndromes. We hypothesized that they might be in with stable ischemic heart disease those at high risk cardiovascular events also prompt revascularization.We measured the cardiac T concentration baseline a high-sensitivity assay 2285 had both type 2 diabetes and were enrolled Bypass Angioplasty Revascularization Investigation Type Diabetes trial. tested an...
CD4 T lymphocytes accumulate in unstable plaque. The direct and indirect involvement of these cells tissue injury plaque instability is not understood.Gene profiling identified perforin, CD161, members the killer-cell immunoglobulin-like receptors as being differentially expressed CD4(+)CD28(null) cells, a T-cell subset that preferentially infiltrates Frequencies CD161(+) perforin-expressing peripheral blood were significantly increased patients with angina (UA). CD161 appeared on after...
Randomized trials comparing coronary angioplasty with bypass surgery in patients multivessel disease have shown no significant differences overall rates of death and myocardial infarction. We compared quality life, employment, medical care costs during five years follow-up among treated or surgery.
Of 2144 patients age 65 years or older entered into the registry of Coronary Artery Surgery Study (CASS) who had coronary arteriography, 1086 underwent isolated artery bypass grafting. Complications angiography included death in four and nonfatal myocardial infarction 17. Eight suffered neurologic complications, which were transient five. The perioperative mortality was 5.2% (57 1086), is significantly greater than 1.9% (151 7827) younger CASS (p less 0.001). There a trend toward an...
Background —Patients with treated diabetes in the randomized-trial segment of Bypass Angioplasty Revascularization Investigation (BARI) who were randomized to initial revascularization PTCA had significantly worse 5-year survival than patients assigned CABG. This treatment difference was not seen among diabetic eligible for BARI opted select their mode revascularization. We hypothesized that differences patient characteristics, assessed and unmeasured, together selection registry, at least...