Lorenzo Razzolini
A5026941768- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Pregnancy and Medication Impact
- Reproductive System and Pregnancy
- Rheumatoid Arthritis Research and Therapies
- Acute Lymphoblastic Leukemia research
- Systemic Lupus Erythematosus Research
- Nutrition and Health in Aging
- Nerve injury and regeneration
- Frailty in Older Adults
- Neurogenesis and neuroplasticity mechanisms
- Aging and Gerontology Research
- Takotsubo Cardiomyopathy and Associated Phenomena
- Body Composition Measurement Techniques
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Health disparities and outcomes
- Long-Term Effects of COVID-19
- Ocular Diseases and Behçet’s Syndrome
- Childhood Cancer Survivors' Quality of Life
- Family Support in Illness
- Autoimmune and Inflammatory Disorders Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Systemic Sclerosis and Related Diseases
- Brain Tumor Detection and Classification
University of Florence
2013-2024
Don Carlo Gnocchi Foundation
2012-2022
University of Bari Aldo Moro
2022
Azienda Ospedaliero-Universitaria Careggi
2021
Vita-Salute San Raffaele University
2014
University of Siena
2013
International Flame Research Foundation
2012
Disability accrual in multiple sclerosis may occur as relapse-associated worsening or progression independent of relapse activity. The role activity early is yet to be established. objective this multicentre, observational, retrospective cohort study was investigate the contribution and confirmed disability accumulation patients with clinically isolated syndrome relapsing-remitting sclerosis, assessed within one year from onset follow-up ≥5 years (n = 5169). Data were extracted Italian...
To test the cognitive reserve (CR) hypothesis in model of multiple sclerosis (MS) by assessing interactions among CR, brain atrophy, and efficiency patients with relapsing-remitting MS.A Cognitive Reserve Index was calculated including education, premorbid leisure activities, IQ. Brain atrophy assessed through magnetic resonance quantitative parameters normalized total volume cortical volume. function measured using Rao's Brief Repeatable Battery.Fifty-two MS were evaluated at baseline 35...
To assess fetal risk after pregnancy exposure to natalizumab in women with multiple sclerosis (MS), a specific focus on spontaneous abortion (SA) and congenital anomalies (CA).Data of all pregnancies occurring between 2009 2015 patients MS treated referring 19 participating sites were collected compared those untreated injectable immunomodulatory agents. Rates SA CA also reported the Italian population. Multivariable logistic linear regression models performed.A total 92 tracked 83 women. In...
An ever-expanding number of disease-modifying drugs for multiple sclerosis have become available in recent years, after demonstrating efficacy clinical trials. In the real-world setting, however, are prescribed patient populations that differ from those included pivotal studies, where extreme age patients usually excluded or under-represented. this multicentre, observational, retrospective Italian cohort study, we evaluated treatment exposure three cohorts with relapsing-remitting defined by...
Abstract Background Few studies have systematically addressed the role of epidural analgesia and caesarean delivery in predicting post-partum disease activity women with Multiple Sclerosis (MS). The objective this study was to assess impact (EA) (CD) on risk relapses disability MS. Methods In context an Italian prospective safety immunomodulators pregnancy, we included pregnancies occurred between 2002 2008 MS regularly followed-up 21 centers. Data were gathered through a standardized,...
Abstract Background Only few studies have assessed safety of in utero exposure to glatiramer acetate (GA). Following a previous study assessing the interferon beta (IFNB) pregnancy multiple sclerosis (MS), we aimed assess and fetal outcomes after GA, using same dataset, with specific focus on risk spontaneous abortion. Materials methods We recruited MS patients, prospectively followed-up 21 Italian Centres, for whom was recorded period 2002–2008. Patients were divided into 2 groups:...
<h3>Objective</h3> To assess relapses, disability progression and the role of disease modifying drugs (DMDs) in year after delivery women with multiple sclerosis (MS). <h3>Methods</h3> We prospectively followed-up pregnancies occurring between 2002 2008 MS, recruited from 21 Italian MS centres. The risk relapses was assessed using time-dependent Cox regression analysis. <h3>Results</h3> 350 out 423 were (pregnancies not resulting live birth a postpartum follow-up period shorter than 1...
<h3>Objective</h3> To assess the risk of disease reactivation during pregnancy after natalizumab suspension in women with multiple sclerosis (MS). <h3>Methods</h3> Data all pregnancies occurring between 2009 and 2015 patients MS treated referring to 19 participating sites were collected compared those untreated injectable immunomodulatory agents through a 2-factor repeated measures analysis. Predictors activity assessed stepwise multivariable logistic regression models. <h3>Results</h3> A...
Abstract Objectives We investigated the occurrence and relative contribution of relapse-associated worsening (RAW) progression independent relapse activity (PIRA) to confirmed disability accrual (CDA) transition secondary (SP) in relapsing multiple sclerosis (MS). Methods Relapsing-onset MS patients with follow-up > / = 5 years (16,130) were extracted from Italian Registry. CDA was a 6-month increase Expanded Disability Status Scale (EDSS) score. Sustained accumulation (SDA) no EDSS...
Background Many potentially modifiable risk factors for MS are investigated. It is not known, however, if these also apply to MS-related cognitive impairment (CI), a frequent consequence of MS. Objective The aim our study was assess CI in patients, focusing on environmental exposures, lifestyle and comorbidities. Methods We included patients referring Centers Florence Barletta between 2014 2017. Neuropsychological performance assessed through the Rao's battery Stroop test, reserve (premorbid...
Importance Although up to 20% of patients with multiple sclerosis (MS) experience onset before 18 years age, it has been suggested that people pediatric-onset MS (POMS) are protected against disability because greater capacity for repair. Objective To assess the incidence and factors associated progression independent relapse activity (PIRA) relapse-associated worsening (RAW) in POMS compared typical adult-onset (AOMS) late-onset (LOMS). Design, Setting, Participants This cohort study on...
The objective of this article is to report our experience on fingolimod suspension in multiple sclerosis patients. We evaluated clinical and magnetic resonance (MR) outcomes six patients after discontinuation. Within three months from suspension, five subjects returned pre-treatment disease activity; one patient, however, exhibited a clear rebound MR activity. Our findings suggest that can vary among Systematic collection clinical, laboratory imaging data highly advisable identify who are at...
Most of Multiple Sclerosis (MS) patients undergo disease modifying drug (DMD) therapy at childbearing age. The objective this prospective, collaborative study, was to assess outcomes pregnancies fathered by MS undergoing DMD. Structured interviews on gathered in the Italian Pregnancy Dataset were collected; divided according father exposure or unexposure DMD time procreation. Treatment compared with multivariable logistic and linear models. Seventy-eight tracked. Forty-five taking conception...
The study of cognitive reserve (CR) in relationship with impairment (CI) pediatric-onset multiple sclerosis (POMS) may provide cues to identifying subjects at higher risk and scope for therapeutic strategies.To assess the potential impact CR on cognition a cohort POMS patients.In all, 48 patients were followed up 4.7 ± 0.4 years. CI was defined as failure ⩾3 tests an extensive neuropsychological battery. Change performance assessed through Reliable Index (RCI) method. At baseline, estimated...
Introduction: Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family, involved in neuronal survival and synaptic plasticity. The BDNF Val66Met polymorphism known to reduce expression secretion; its role multiple sclerosis (MS) poorly investigated. Objectives Methods: In this multicenter, retrospective study, we assessed on cognitive motor disability MS patients consecutively referred University Florence Hospital Barletta. All underwent genetic analysis for presence...
The influence of pregnancy on long-term disability in multiple sclerosis (MS) is still controversial.To assess the risk worsening after MS women as compared with a propensity-score (PS) matched group without pregnancy.In setting Italian Pregnancy Dataset, patients (pregnancy (PG)) and (control (CG)) were recruited. Time to Expanded Disability Status Scale (EDSS) was assessed through multivariable Cox regression model.The PS-matching retained 230 PG 102 CG patients. After follow-up 6.5 +/-...
Except for ocrelizumab, treatment options in primary progressive multiple sclerosis (PPMS) are lacking.To investigate the effectiveness of DMTs on risk becoming wheelchair dependent a real-world population patients with PPMS.This was multicenter, observational, retrospective, comparative research study. Data were extracted November 28, 2018, from Italian register and analyzed June to December 2021. Mean study follow-up 11 years. Included cohort diagnosis PPMS at least 3 years Expanded...