A5022512770- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Head and Neck Cancer Studies
- Tissue Engineering and Regenerative Medicine
- Reconstructive Surgery and Microvascular Techniques
- Hematopoietic Stem Cell Transplantation
- Effects of Radiation Exposure
- Periodontal Regeneration and Treatments
- Wound Healing and Treatments
- Oral health in cancer treatment
- Salivary Gland Disorders and Functions
- Ear and Head Tumors
- Body Contouring and Surgery
- Renal Transplantation Outcomes and Treatments
- Genital Health and Disease
- Xenotransplantation and immune response
- Immune Cell Function and Interaction
- Multiple Sclerosis Research Studies
- Organ Donation and Transplantation
Rigshospitalet
2012-2023
Copenhagen University Hospital
2012-2023
University of Copenhagen
2016-2019
Creative Commons
2019
Stanford University
2019
Aleris Hamlet Hospital
2019
Herlev Hospital
2019
Background: Cell-enrichment of fat grafts has produced encouraging results, but the optimal concentrations and types added cells are unknown. The authors investigated effects enrichment with various ex vivo–expanded adipose-derived stem/stromal stromal vascular fraction on graft retention in a porcine model. Methods: Adipose-derived were culture-expanded, six (30 ml) prepared for each minipig ( n = 13). enriched 2.5 × 10 6 to 20 stem cells/ml nonenriched control grafts. Each pig served as...
Summary: Several techniques for measuring breast volume (BV) are based on examining the magnetic resonance imaging. However, when designed to measure total BV used quantify changes, example, after fat grafting, a systematic error is introduced because changes lead contour alterations of breast. The altered includes not only injected but also tissue previously surrounding Therefore, quantitative difference in before and augmentation will differ from volume. Here, we present new technique that...
Background: Cell-enriched fat grafting has shown promising results for improving graft survival, although many questions remain unanswered. A large animal model is crucial bridging the gap between rodent studies and human trials. We present a step-by-step approach in using Göttingen minipig as future of cell-enriched volume grafting. Methods: Fat was performed bolus injections structural Graft retention assessed by magnetic resonance imaging after 120 days. The stromal vascular fraction...
Hyperbaric oxygen, (HBO) is used to treat several conditions including late radiation tissue injury. Previous studies have suggested that HBO mobilizes bone marrow derived stem/progenitor cells (SPC) the peripheral blood, however possible cumulative effects were highly variable.We investigated a HBO-induced mobilization of SPCs by determining CD34+CD45dim cell numbers, as well in general. The latter characterized high aldehyde dehydrogenase (ALDH) activity use Aldefluor® assay. We included...
Abstract Background Fat grafting is commonly utilized in breast surgery, and since it was first described, clinicians researchers have stridden towards improvement of graft retention. Current advancements include adding adipose-derived mesenchymal stem/stromal cells (MSC(AT)s), which demonstrated promise for improved Objectives This study reports outcomes the twenty-two patients undergoing augmentation (Stemform BA) or artificial implant replacement AIR) with MSC(AT)-enriched fat a...
Abstract The Nordic Register of Haematopoietic Stem Cell Donors (NRHSD) has registered related and unrelated donors from 10 transplant centres in Sweden, Norway, Finland Denmark since 1998. We present a prospective, observational study 1,957 donors, focusing mainly on the differences between donors. Related are reported to have more comorbidities, but similar side effects compared with Side after BM or PBSC donation generally short duration this no deaths, myocardial infarctions, splenic...
BACKGROUND: The main problem with fat grafting is the postoperative graft resorption which often leads to repeated procedures achieve desired volume. Cell therapy in form of adding stromal vascular fraction or culture-expanded, adipose-derived cells are some most promising strategies improve retention.1 To assess efficacy using high-dose, enhance volume retention human breast, we have conducted a randomized, double-blind, placebo-controlled clinical trial. METHODS: This trial was performed...
<div>AbstractPurpose:<p>Mesenchymal stem/stromal cell therapy may reduce radiation-induced xerostomia. We investigated the long-term safety of autologous adipose tissue-derived mesenchymal (ASC) injections into submandibular glands.</p>Experimental Design:<p>An investigator-initiated, randomized, single-center, placebo-controlled trial. Previous patients with oropharyngeal squamous carcinoma xerostomia were randomly (1:1) allocated to receive a 2.8 million...
Supplementary Data from Long-term Safety of Treatment with Autologous Mesenchymal Stem Cells in Patients Radiation-Induced Xerostomia: Primary Results the MESRIX Phase I/II Randomized Trial
Supplementary Data from Long-term Safety of Treatment with Autologous Mesenchymal Stem Cells in Patients Radiation-Induced Xerostomia: Primary Results the MESRIX Phase I/II Randomized Trial
<div>AbstractPurpose:<p>Mesenchymal stem/stromal cell therapy may reduce radiation-induced xerostomia. We investigated the long-term safety of autologous adipose tissue-derived mesenchymal (ASC) injections into submandibular glands.</p>Experimental Design:<p>An investigator-initiated, randomized, single-center, placebo-controlled trial. Previous patients with oropharyngeal squamous carcinoma xerostomia were randomly (1:1) allocated to receive a 2.8 million...
Background: Innate effector cells are of increasing interest in relation to graft-versus-leukemia effects and immune reconstitution after allogeneic hematopoietic stem cell transplantation. The aim this study was characterize the contents γδ T NK grafts for transplantation compare bone marrow (BM) with G-CSF mobilized peripheral blood (PBSC). Methods: From 2015 2017 samples from 111 consecutive were analyzed at Stem Cell Transplant Unit, Rigshospitalet, Denmark. Graft freshly prepared white...