A5004899856- Cancer Immunotherapy and Biomarkers
- Advancements in Transdermal Drug Delivery
- Burn Injury Management and Outcomes
- CAR-T cell therapy research
- Tryptophan and brain disorders
- Wound Healing and Treatments
- Dermatology and Skin Diseases
- Virus-based gene therapy research
- Immune cells in cancer
- Mesenchymal stem cell research
- Cancer, Stress, Anesthesia, and Immune Response
- Antibiotics Pharmacokinetics and Efficacy
- Pediatric Pain Management Techniques
- Pain Mechanisms and Treatments
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Pain Management and Opioid Use
- TGF-β signaling in diseases
- Monoclonal and Polyclonal Antibodies Research
- Contact Dermatitis and Allergies
- Phagocytosis and Immune Regulation
- Reconstructive Surgery and Microvascular Techniques
- Male Breast Health Studies
- LGBTQ Health, Identity, and Policy
- Breast Implant and Reconstruction
Copenhagen University Hospital
2012-2024
Rigshospitalet
2008-2024
University of Copenhagen
2011-2024
Loxo Oncology at Lilly (United States)
2024
Stanford University
2019
Aleris Hamlet Hospital
2019
Herlev Hospital
2019
Eli Lilly (United States)
2016-2018
Memorial Sloan Kettering Cancer Center
2013-2017
Swim Across America
2013-2016
Preexisting lymphocytic infiltration of tumors is associated with superior prognostic outcomes in a variety cancers. Recent studies also suggest that responses may identify patients more likely to benefit from therapies targeting immune checkpoints, suggesting therapeutic efficacy checkpoint blockade can be enhanced through strategies induce tumor inflammation. To achieve this effect, we explored the immunotherapeutic potential oncolytic Newcastle disease virus (NDV). We find localized...
The cytotoxic T lymphocyte antigen-4 (CTLA-4)–blocking antibody ipilimumab results in durable responses metastatic melanoma, though therapeutic benefit has been limited to a fraction of patients. This calls for identification resistance mechanisms and development combinatorial strategies. Here, we examine the inhibitory role indoleamine 2,3-dioxygenase (IDO) on antitumor efficacy CTLA-4 blockade. In IDO knockout mice treated with anti–CTLA-4 antibody, demonstrate striking delay B16 melanoma...
Highlights•Tumor IDO mediates local/systemic immunosuppression and resistance to immunotherapy•IDO expression in human mouse tumors is associated with MDSC infiltration•Tumor induces by expanding, recruiting, activating MDSCs•Tumor-IDO-mediated recruitment activation of MDSCs are Treg dependentSummaryIndoleamine 2,3-dioxygenase (IDO) has been described as a major mechanism tumors, though the mechanisms this poorly understood. Here, we find that tumor cells results aggressive growth...
<h3>Background</h3> TGFβ signaling plays a pleotropic role in tumor biology, promoting proliferation, invasion and metastasis, escape from immune surveillance. Inhibiting TGFβ's suppressive effects has become of particular interest as way to increase the benefit cancer immunotherapy. Here we utilized preclinical models explore impact clinical stage pathway inhibitor, galunisertib, on anti-tumor immunity at clinically relevant doses. <h3>Results</h3> In vitro treatment with galunisertib...
The tumor microenvironment is profoundly immunosuppressive. We show that multiple types create intratumoral immune suppression driven by a specialized form of regulatory T cell (Treg) activation dependent on the PTEN (phosphatase and tensin homolog) lipid phosphatase. acted to stabilize Tregs in tumors, preventing them from reprogramming into inflammatory effector cells. In mice with Treg-specific deletion PTEN, tumors grew slowly, were inflamed, could not an immunosuppressive...
Tumor indoleamine 2,3-dioxygenase (IDO) promotes immunosuppression by direct action on effector T cells and Tregs through recruitment, expansion activation of myeloid-derived suppressor (MDSCs). Targeting MDSCs is clinically being explored as a therapeutic strategy, though optimal targeting strategies biomarkers predictive response are presently unknown. Maturation tumor recruitment dependent signaling the receptor tyrosine kinase CSF-1R myeloid cells. Here, we show that critical cell...
// Jonathan M. Yingling 1 , William T. McMillen 2 Lei Yan Huocong Huang 3 J. Scott Sawyer Jeremy Graff David K. Clawson Karen S. Britt Bryan D. Anderson Douglas W. Beight Durisala Desaiah Michael Lahn Karim A. Benhadji Maria Lallena Rikke B. Holmgaard Xiaohong Xu Faming Zhang Jason R. Manro Philip Iversen Chandrasekar V. Iyer Rolf Brekken Kalos and Kyla E. Driscoll Idera Pharmaceuticals, Inc., Cambridge, Massachusetts, USA Lilly Research Laboratories, Eli Company, Indianapolis, IN New York,...
Abstract Emerging data suggest that locoregional cancer therapeutic approaches with oncolytic viruses can lead to systemic anti-tumour immunity, although the appropriate targets for intratumoral immunomodulation using this strategy are not known. Here we find therapy Newcastle disease virus (NDV), in addition activation of innate upregulates expression T-cell co-stimulatory receptors, inducible co-stimulator (ICOS) being most notable. To explore ICOS as a direct target tumour, engineered...
Colony stimulating factor-1 (CSF-1) is produced by a variety of cancers and recruits myeloid cells that suppress antitumor immunity, including myeloid-derived suppressor (MDSCs.) Here, we show both CSF-1 its receptor (CSF-1R) are frequently expressed in tumors from cancer patients, this expression correlates with tumor-infiltration MDSCs. Furthermore, demonstrate these tumor-infiltrating MDSCs highly immunosuppressive but can be reprogrammed toward an phenotype vitro upon CSF-1/CSF-1R...
Meeting abstracts The tumor microenvironment is profoundly immunosuppressive, but exactly how this coordinated and maintained remains poorly understood. We show that multiple transplantable autochthonous mouse tumors actively elicit a population of highly suppressive regulatory T cells (
Background: Cell-enrichment of fat grafts has produced encouraging results, but the optimal concentrations and types added cells are unknown. The authors investigated effects enrichment with various ex vivo–expanded adipose-derived stem/stromal stromal vascular fraction on graft retention in a porcine model. Methods: Adipose-derived were culture-expanded, six (30 ml) prepared for each minipig ( n = 13). enriched 2.5 × 10 6 to 20 stem cells/ml nonenriched control grafts. Each pig served as...
Abstract Nectin-4 is an immunoglobulin-like antigen overexpressed in a variety of cancers including bladder, breast, NSCLC, and gastric. Normal tissues skin, salivary glands, bladder esophagus express only low to medium levels making the protein attractive target for cancer therapies. The approval enfortumab vedotin-ejfv, anti-Nectin-4 based antibody-drug conjugate (ADC) with microtubule inhibitor payload, either as single agent or combination pembrolizumab has been significant advancement...
<b><i>Aim:</i></b> To study the influence of chronological age on fentanyl permeation through human skin in vitro using static diffusion cells. Elderly individuals are known to be more sensitive opioids and obtain higher plasma concentrations following dermal application compared younger individuals. The - as an isolated pharmacokinetic term absorption has not been previously studied. <b><i>Method:</i></b> Human from 30 female donors was...
Microdialysis (MD) in the skin - dermal microdialysis (DMD) is a unique technique for sampling of topically as well systemically administered drugs at site action, e.g. dermatological drug concentrations dermis. Debate has concerned existence correlation between depth device probe dermis and amount sampled following topical administration. This study evaluates relation using DMD ex vivo human skin. We used superficial (<1 mm), intermediate (1-2 mm) deep (>2 positioning linear MD abdominal...
Purpose: In recent years, there has been a significant increase in referrals for gender-affirming surgery to departments of plastic Denmark. There is currently no literature on postsurgical pain trans men after mastectomy. We aimed at investigating the prevalence and severity persistent pain, sensory disturbances, complications Methods: The 90 who underwent bilateral mastectomy between September 1, 2013 August 31, 2018 were included. Patients' files evaluated complications, 84 (response rate...
Top surgery, or masculinization of the chest, is often first and sometimes only procedure in gender-affirming surgery for transgender- gender-diverse persons assigned female at birth. In recent years, there has been improved access to care transgender individuals increased demand top surgery. Our aim was investigate degree satisfaction with postoperative outcome after men.