A5068405667- Glioma Diagnosis and Treatment
- Chromatin Remodeling and Cancer
- Neuroblastoma Research and Treatments
- Molecular Biology Techniques and Applications
- Forensic and Genetic Research
- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- MicroRNA in disease regulation
- Cancer Treatment and Pharmacology
- Genetic factors in colorectal cancer
- Brain Metastases and Treatment
- Genetics and Neurodevelopmental Disorders
- Boron Compounds in Chemistry
- Sarcoma Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Cancer Research and Treatments
- Genomics and Phylogenetic Studies
- Cancer Genomics and Diagnostics
- Drug Transport and Resistance Mechanisms
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- Hippo pathway signaling and YAP/TAZ
- Cancer-related molecular mechanisms research
- Celiac Disease Research and Management
- Microtubule and mitosis dynamics
Meyer Children's Hospital
2015-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2023-2024
Meyer Children's Hospital
2024
University of Milano-Bicocca
2017-2020
RELX Group (United States)
2017
University of Florence
2000-2014
Temple Street Children's University Hospital
2014
Medical Genetics Center
2014
Boston Children's Hospital
2009
University of Siena
1998
In children, sporadic nephrotic syndrome can be related to a genetic cause, but what extent alterations associate with resistance immunosuppression is unknown. this study, we designed custom array for next-generation sequencing analysis of 19 target genes, reported as possible causes syndrome, in cohort 31 children affected by steroid-resistant and 38 patients who exhibited similar steroid-sensitive clinical phenotype. Patients extrarenal symptoms, had familial history the disease or...
Pediatric high-grade gliomas (pHGGs) encompass a heterogeneous group of tumors. Three main molecular types (H3.3 mutant, IDH and H3.3/IDH wild-type) number subtypes have been identified. We provide an overview pHGGs present mono-institutional series. studied eleven non-related pHGG samples through combined approach routine diagnostic tools gene panel. TP53 H3F3A were the most mutated genes (six patients each, 54%). The third was EGFR (three patients, 27%), followed by PDGFRA PTEN (two 18%)....
Myxoid glioneuronal tumor (MGT) is a benign neoplasm recently introduced in the World Health Organization (WHO) classification of central nervous system (CNS) tumors. MGTs are typically located septum pellucidum, foramen Monro or periventricular white matter lateral ventricle. They were previously diagnosed as dysembryoplastic neuroepithelial tumors (DNT), showing histological features almost indistinguishable from classical cortical DNT. Despite that, have been associated with specific...
Embryonal tumors are a group of malignant neoplasms that most commonly affect the pediatric population. tumor with abundant neuropil and true rosettes is recently recognized rare tumor. It composed neurocytes undifferentiated neuroepithelial cells arranged in clusters, cords several types prominent neuropil-rich background. We describe new case this The patient, 24-month-old female infant, was referred to Meyer Children's Hospital history right brachio-crural deficit associated occasional...
Rhabdoid meningioma is an uncommon variant categorized as WHO grade III. The majority of cases occur in adulthood. Herein, we describe a right fronto-temporal rhabdoid affecting 3-year-old boy. lesion measured approximately 4 cm diameter and incorporated the ipsilateral middle cerebral artery. Sub-total surgical excision mass was performed. Histologically, tumor mainly composed globoid plump cells with inclusion-like eosinophilic cytoplasm, peripheral nuclei, prominent nucleoli occasional...
Lynch syndrome (LS) is a tumor predisposing condition caused by constitutional defects in genes coding for components of the mismatch repair (MMR) apparatus. While hypermethylation promoter MMR gene MLH1 occurs about 15% colorectal cancer samples, it has also been observed as alteration, absence DNA sequence mutations, small number LS patients. In order to obtain further insights on phenotypic characteristics epimutation carriers, we investigated somatic and methylation status 14 unrelated...
MicroRNAs (miRNAs/miRs) are a novel class of gene regulators that may be involved in tumor chemoresistance. Recently, specific miRNA expression profiles have been identified adult glioblastoma (aGBM), but there only limited data available on the role miRNAs pediatric GBM (pGBM). In present study, profile was examined seven pGBMs and three human cell lines (U87MG, A172 T98G), compared with non‑tumoral pool cerebral cortex samples by microarray analysis. A set differentially expressed...
Whenever the carbon/nitrogen ratio of a domestic wastewater is too low, full denitrification difficult to obtain and an additional source organic carbon has be provided. Since loading conditions may vary appreciably over diurnal cycle, depending on weather sewage conditions, dosing should controlled by adaptive regulator keep into account time-varying process dynamics. A fuzzy predictive controller proposed in this paper its performance tested through numerical simulations. The new aspects...
Hamartomatous polyposis syndromes (HPS) are inherited conditions associated with high cancer risk. They include the Peutz-Jeghers and PTEN hamartoma tumor syndromes, which caused by mutations in LKB1 genes, respectively. Estimation of risk is crucial order to optimize surveillance, but no prognostic markers currently available for these conditions. Our study relies on a 'signal transduction' hypothesis based crosstalk between LKB1/AMPK PI3K/PTEN/Akt signaling at level suppressor protein...