A5033907581- Renal cell carcinoma treatment
- Glioma Diagnosis and Treatment
- Renal and related cancers
- Pregnancy and preeclampsia studies
- Genetic factors in colorectal cancer
- Neuroblastoma Research and Treatments
- Gastrointestinal Tumor Research and Treatment
- Inflammatory Bowel Disease
- Multiple and Secondary Primary Cancers
- Sarcoma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Thyroid Cancer Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Estrogen and related hormone effects
- Ovarian cancer diagnosis and treatment
- Hemoglobinopathies and Related Disorders
- Chromatin Remodeling and Cancer
- Soft tissue tumor case studies
- Genetic and Kidney Cyst Diseases
- Melanoma and MAPK Pathways
- Global Cancer Incidence and Screening
- Cutaneous Melanoma Detection and Management
- Tuberous Sclerosis Complex Research
University of Florence
2008-2024
Azienda Ospedaliero-Universitaria Careggi
2013-2024
Azienda Sanitaria Locale CN2
1996-2015
Meyer Children's Hospital
2015
Centro Regional de Derechos Humanos y Justicia de Género, Corporación Humanas
2008
Subependymal giant‐cell astrocytoma (SEGA) is a rare intra‐ventricular low‐grade tumor which frequently occurs as manifestation of tuberous sclerosis complex. The histogenesis SEGA controversial and its astrocytic nature has been doubted. First studies suggested the while several recent reports demonstrate glio‐neuronal nature. In spite this, in recently revised WHO classification CNS tumors, still included group astrocytomas. We studied nine complex‐associated SEGAs. Patients were 1–18...
Pediatric high-grade gliomas (pHGGs) encompass a heterogeneous group of tumors. Three main molecular types (H3.3 mutant, IDH and H3.3/IDH wild-type) number subtypes have been identified. We provide an overview pHGGs present mono-institutional series. studied eleven non-related pHGG samples through combined approach routine diagnostic tools gene panel. TP53 H3F3A were the most mutated genes (six patients each, 54%). The third was EGFR (three patients, 27%), followed by PDGFRA PTEN (two 18%)....
Introduction. Endometrial carcinoma (EC) is the commonest gynecological cancer affecting women in Western populations. To predict patient risk, 2020 edition of World Health Organization (WHO) Classification Tumors Female Genital Tract stressed importance integrated histo-molecular classification disease. This survey analysis poses attention on most frequently used immunohistochemical and molecular markers adopted daily categorization ECs European laboratories.Methods. We analyzed data...
Cancer progression is supported by the cross-talk between tumor cells and surrounding stroma. In this context, senescent in microenvironment contribute to development of a pro-inflammatory milieu acquisition aggressive traits cancer cells. Anticancer treatments induce cellular senescence (therapy-induced senescence, TIS) both non-cancerous cells, contributing many detrimental side effects therapies. Thus, we focused on chemotherapy stromal compartment prostate ovarian cancer. We demonstrated...
Background: Approximately 25.0% of metastatic prostate cancer patients harbour DNA damage repair mutations, including BRCA1 and BRCA2, which are actionable targets for poly(ADP-ribose) polymerase (PARP) inhibitors. Accurate detection BRCA1/2 mutations is critical guiding targeted therapies, but crucial pre-analytical factors, such as tissue storage duration fragmentation, drastically affect the reliability next-generation sequencing (NGS) using real-world diagnostic specimens. Methods: This...
Post-mortem interval (PMI) estimation remains one of the major challenges in forensic practice, especially for late PMIs beyond 7–10 days after death subject. In 2022, an innovative method to investigate occurrence mutations induced by a subject DNA post-mortem dental pulps at different was developed, applying next-generation sequencing (NGS) analysis. The present study aims apply same analysis small sample teeth belonging and analyzed PMIs/accumulated degree (ADDs), extracted from subjects...
In 1998, when data of a meta-analysis on tamoxifen in the treatment hepatocellular carcinoma (HCC) had suggested little advantage for this treatment, we published results multicenter randomised controlled trial, that showed no survival benefit vs. control. Here report an updated analysis study 4.5 years after closure enrollment.The planned sample size 480 patients. Patients with any stage HCC were eligible, irrespective locoregional treatment. Tamoxifen was given orally, 40 mg/die, from...
To investigate the proportion of stillbirths at term associated with abnormal growth using customized birth weight percentiles and to compare histological placental findings both in underweight stillborn fetuses live births.A retrospective case-control study 150 singleton stillbirths. The livebirth control groups included 586 cases low-risk pregnancies 153 late fetal restriction fetuses. Stillbirths livebirths from were classified standards for birth, as adequate gestational age (AGA;...
The variety of placental morphological findings with SARS-CoV-2 maternal infections has raised the issue poor agreement in histopathological evaluation. aims this study were: to describe features a large sample SARS-CoV-2-positive women who gave birth Italy during COVID-19 pandemic, analyse factors underlying these lesions, and impact impairment on perinatal outcomes. From 25 February 2020 30 June 2021, experienced pathologists examined 975 placentas mothers enrolled national prospective...
Ependymomas are the third most common brain tumor in children. The post surgical management is controversial. There no convincing data on an effective role for chemotherapy. O(6)-Methylguanine-DNA-Methyltransferase (MGMT) a DNA repair protein considered to be chemosensitivity predictor. Hypermethylation of MGMT gene promoter important cause inactivation. We evaluated methylation and immunohistochemical expression 12 recurrent anaplastic ependymomas affecting Our purpose was investigate...
Mutations in IDH1 gene are observed gliomas with significant differences according to histotype, grade, prognosis, and age. We analyzed the mutations frequency 42 from 40 children (14 pilocytic astrocytomas; 3 pilomyxoid diffuse 1 gliomatosi cerebri; 8 subependymal giant cell 2 anaplastic 9 glioblastomas). No mutation was detected. Our results indicate that there is no involvement onset progression of pediatric astrocytomas. argue it not useful assess status nor for diagnostic prognostic purposes.
Angiocentric glioma is a rare slow growing tumor. It associated to seizures and mainly diagnosed in children young adults. We describe the clinical, histo-pathological molecular (IDH1, IDH2 BRAFV600E mutational status) features 3 children, 2 girls (2- 11-years old) 1 boy (10-years old). The tumors were located at left temporo-parietalinsular, parieto-occipital subcortical paramedian region respectively. All patients operated. Two are well 16 months of follow-up while third still suffers from...
Fibrosarcomas diagnosed during the early years of life are called congenital/infantile fibrosarcomas. They differ from adult fibrosarcomas because their limited aggressive outcome. Congenital/infantile occur most frequently on extremities. This article describes an exceptional case colonic fibrosarcoma in a 3-day-old baby boy. It is third intestinal reported international literature. The lesion was radically excised. Microscopic examination revealed densely cellular and poorly circumscribed...
Atypical Spitz tumors (AST) deviate from stereotypical nevi for one or more atypical features and are now regarded as an intermediate category of melanocytic with uncertain malignant potential. Activating NTRK1/NTRK3 fusions elicit oncogenic events in lesions targetable kinase inhibitors. However, their prevalence among ASTs the optimal approach detection is yet to be determined. A series 180 were screened pan-TRK immunohistochemistry presence NTRK was confirmed using FISH, two different...
Abstract Endometriosis is a chronic gynecological disease affecting ~10% women in the reproductive age characterized by growth of endometrial glands and stroma outside uterine cavity. The inflammatory process has key role initiation progression disorder. Currently, there are no available early diagnostic tests therapy relies exclusively on symptomatic drugs, so that elucidation complex molecular mechanisms involved pathogenesis endometriosis an unmet need. signaling bioactive sphingolipid...
Clear cell papillary renal carcinoma (CCPRCC) cases were evaluated for mutations on the following genes: KRAS, NRAS, BRAF, PIK3CA, ALK, ERBB2, DDR2, MAP2K1, RET and EGFR. Four male three female patients of age 42-74 years evaluated. All incidentally detected by ultrasound ranged 1.8-3.5 cm. Microscopic examination showed variably tubulopapillary, tubular acinar, cystic architecture characteristic linear arrangement nuclei. The cells reactive with CK7 (strong), CA IX (cup-shape) 34 β E12....
Diencephalic Syndrome is a rare clinical condition of failure to thrive despite normal caloric intake, hyperalertness, hyperkinesis, and euphoria usually associated with low-grade hypothalamic astrocytomas.
Pilomyxoid astrocytoma is a recently described tumor. Its most typical morphological characteristics are an angiocentric astrocytic proliferation embedded in myxoid background. The behavior seems to be unfavorable due the reported high rate of local recurrence. earlier studies indicated that pilomyxoid typically affects young children and arises hypothalamic/chiasmatic region. We report case 14-year-old patient with 6-year history absence seizure. Magnetic resonance imaging showed right...
<i>Aims:</i> The aim of this study was to evaluate the utility liquid-based cytology for endometrial surveillance in patients receiving tamoxifen. <i>Methods:</i> One hundred and sixty-eight women scheduled hysteroscopy were enrolled study. sequentially underwent hysteroscopy, biopsy. <i>Results:</i> Endometrial biopsy only inadequate 112 (67%) patients, both 19 (11%) 4 (2%) adequate 33 (20%) patients. Overall, 131 (78%) 23 (14%) provided sufficient...