A5024452418- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- Galectins and Cancer Biology
- Protein Tyrosine Phosphatases
- Cancer Cells and Metastasis
- Immune cells in cancer
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Atherosclerosis and Cardiovascular Diseases
- Histone Deacetylase Inhibitors Research
- Cytokine Signaling Pathways and Interactions
- 3D Printing in Biomedical Research
- Adipose Tissue and Metabolism
- ATP Synthase and ATPases Research
- Tea Polyphenols and Effects
- Extracellular vesicles in disease
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Fungal Biology and Applications
- Lipid metabolism and biosynthesis
University of Florence
2020-2025
Abstract Lactate is an abundant oncometabolite in the tumor environment. In prostate cancer, cancer-associated fibroblasts (CAF) are major contributors of secreted lactate, which can be taken up by cancer cells to sustain mitochondrial metabolism. However, how lactate impacts transcriptional regulation tumors has yet fully elucidated. Here, we describe a mechanism CAF-secreted able increase expression genes involved lipid metabolism cells. This enhanced intracellular accumulation droplets...
5-Fluorouracil (5-FU) is a key component of chemotherapy for colorectal cancer (CRC). 5-FU efficacy established by intracellular levels folate cofactors and DNA damage repair strategies. However, drug resistance still represents major challenge. Here, we report that alterations in serine metabolism affect sensitivity vitro vivo CRC models. In particular, 5-FU-resistant cells display strong dependency achieved either upregulating endogenous synthesis or increasing exogenous uptake....
Cancer progression is supported by the cross-talk between tumor cells and surrounding stroma. In this context, senescent in microenvironment contribute to development of a pro-inflammatory milieu acquisition aggressive traits cancer cells. Anticancer treatments induce cellular senescence (therapy-induced senescence, TIS) both non-cancerous cells, contributing many detrimental side effects therapies. Thus, we focused on chemotherapy stromal compartment prostate ovarian cancer. We demonstrated...
Melanoma is more aggressive in male patients than female ones and this associated with sexual dimorphism immune responses. Taking into consideration the impact tumour metabolic alterations affecting landscape, we aimed to investigate effect of sex-dependent profile melanoma re-shaping composition. characterised by Warburg metabolism, secreted lactate has emerged as a key driver establishment an immunosuppressive environment. Here, identified dehydrogenase A (LDH-A) crucial player modulating...
Abstract Cancer-associated fibroblasts (CAFs) are one of the main components stromal compartment in tumor microenvironment (TME) and crosstalk between CAFs cancer cells is essential for progression aggressiveness. Cancer mediate an activation process, converting normal into CAFs, that characterized by modified expression many proteins increased production release microvesicles (MVs), extracellular vesicles generated outwards budding from cell membrane. Recent evidence underlined uptake...
Metastatic melanoma is characterized by poor prognosis and a low free-survival rate. Thanks to their high plasticity, cells are able migrate exploiting different cell motility strategies, such as the rounded/amoeboid-type elongated/mesenchymal-type motility. In particular, amoeboid strongly contributes dissemination of highly invasive no treatment targeting this process currently available for clinical application. Here, we tested Claisened Hexafluoro novel inhibitor Reported data...
<div>Abstract<p>Lactate is an abundant oncometabolite in the tumor environment. In prostate cancer, cancer-associated fibroblasts (CAF) are major contributors of secreted lactate, which can be taken up by cancer cells to sustain mitochondrial metabolism. However, how lactate impacts transcriptional regulation tumors has yet fully elucidated. Here, we describe a mechanism CAF-secreted able increase expression genes involved lipid metabolism cells. This enhanced intracellular...
Supplementary Data from Lactate Rewires Lipid Metabolism and Sustains a Metabolic–Epigenetic Axis in Prostate Cancer
Supplementary Data from Lactate Rewires Lipid Metabolism and Sustains a Metabolic–Epigenetic Axis in Prostate Cancer
<div>Abstract<p>Lactate is an abundant oncometabolite in the tumor environment. In prostate cancer, cancer-associated fibroblasts (CAF) are major contributors of secreted lactate, which can be taken up by cancer cells to sustain mitochondrial metabolism. However, how lactate impacts transcriptional regulation tumors has yet fully elucidated. Here, we describe a mechanism CAF-secreted able increase expression genes involved lipid metabolism cells. This enhanced intracellular...