A5086203994- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- RNA Interference and Gene Delivery
- Cytokine Signaling Pathways and Interactions
- Ubiquitin and proteasome pathways
- Cancer therapeutics and mechanisms
- Estrogen and related hormone effects
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- Tannin, Tannase and Anticancer Activities
- RNA Research and Splicing
- Protein Degradation and Inhibitors
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- DNA Repair Mechanisms
- Steroid Chemistry and Biochemistry
- DNA and Nucleic Acid Chemistry
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
Institute of Oncology Research
2016-2025
IRCCS Humanitas Research Hospital
2025
Università della Svizzera italiana
2006-2024
University of Lausanne
2016-2020
SIB Swiss Institute of Bioinformatics
2018-2020
University Hospital of Lausanne
2017
Scuola Cantonale di Commercio Bellinzona
2015
Institute of Oncology NN Petrov
2013
University of Insubria
2012-2013
University of Bern
2012-2013
Prosenescence therapy has recently emerged as a novel therapeutic approach for treating cancer. However, this concept is challenged by conflicting evidence showing that the senescence-associated secretory phenotype (SASP) of senescent tumor cells can have pro- well antitumorigenic effects. Herein, we report that, in Pten-null tumors, activation Jak2/Stat3 pathway establishes an immunosuppressive microenvironment contributes to growth and chemoresistance. Activation tumors sustained...
Abstract Lactate is an abundant oncometabolite in the tumor environment. In prostate cancer, cancer-associated fibroblasts (CAF) are major contributors of secreted lactate, which can be taken up by cancer cells to sustain mitochondrial metabolism. However, how lactate impacts transcriptional regulation tumors has yet fully elucidated. Here, we describe a mechanism CAF-secreted able increase expression genes involved lipid metabolism cells. This enhanced intracellular accumulation droplets...
Summary Among B‐cell lymphomas mantle cell lymphoma (MCL) has the worst prognosis. By using a combination of genomic and expression profiling (Affymetrix GeneChip Mapping 10k Xba131 U133 set), we analysed 26 MCL samples to identify genes relevant pathogenesis that could represent new therapeutic targets. Recurrent deletions gains were detected. Genes identified as overexpressed in regions DNA gain on 3q, 6p, 8q, 9q, 16p 18q, including cancer BCL2 MYC . transcripts with high correlation...
Background ETS transcription factors regulate important signaling pathways involved in cell differentiation and development many tissues have emerged as players prostate cancer. However, the biological impact of tumorigenesis is still debated. Methodology/Principal Findings We performed an analysis gene family using microarray data real-time PCR normal tumor along with functional studies cancer lines to understand identify key targets these factors. found frequent dysregulation genes...
New discoveries in RNA biology underscore a need for chemical tools to clarify their roles pathophysiological mechanisms. In certain cancers, synthesis of the let-7 microRNA tumor suppressor is blocked by an binding protein (RBP) Lin28, which docks onto conserved sequence precursor molecules and prevents maturation. Thus, Lin28/let-7 interaction might be attractive drug target, if not well-known difficulty targeting RNA-protein interactions with drugs. Here, we describe protein/RNA FRET...
Cancer stem cells (CSC) play a significant role in tumor progression, disease recurrence, and treatment failure. Here, we show that the endogenously expressed ETS transcription factor ESE3/EHF controls prostate epithelial cell differentiation stem-like potential. We found loss of induced epithelial-to-mesenchymal transition (EMT), features, tumor-initiating metastatic properties cells, reexpression inhibited tumorigenic potential cancer cells. Mechanistically, repressed expression key EMT...
Significance The transcription factor STAT3 is involved in multiple oncogenic signaling pathways and an attractive therapeutic target. This study shows that a potent inhibitor of interferes with mitochondrial activity protein homeostasis, leading to synthetic lethality effect glucose-depleted cancer cells. These findings provide rationale for novel strategies based on the use inhibitors treatment.
Short double-stranded RNAs, which are known as short interfering RNA (siRNA), can be used to specifically down-regulate the expression of targeted gene in a process interference (RNAi). However, success silencing applications based on use synthetic siRNA critically depends efficient intracellular delivery. Polycationic branched macromolecules such poly(amidoamine) (PAMAM) dendrimers show strong binding affinity for molecules and, hence, provide an effective, reproducible, and relatively...
Several studies link disease progression, recurrence, and treatment failures to the cancer stem-like cell (CSC) subpopulation within heterogeneous tumor population. Myc is a transcription factor having central function in stem biology human cancers. Hence, represents an attractive target develop CSC-specific therapies. Recent findings suggest that can be silenced using RNA interference (RNAi)-based strategy targets noncoding promoter-associated (paRNA) overlapping start site. In this study,...
STAT3 is a key element in many oncogenic pathways and, like other transcription factors, an attractive target for development of novel anticancer drugs. However, interfering with functions has been difficult task and very few small molecule inhibitors have made their way to the clinic. OPB‐31121, compound currently clinical trials, reported affect signaling, although its mechanism action not unequivocally demonstrated. In this study, we used combined computational experimental approach...
Chromosomal translocations leading to deregulated expression of ETS transcription factors are frequent in prostate tumors. Here, we report a novel mechanism oncogenic activation the factor ESE1/ELF3 was overexpressed human primary and metastatic It mediated transforming phenotypes vitro vivo induced an inflammatory transcriptome with changes relevant pathways. by interleukin (IL)-1β through NF-κB crucial mediator phenotypic transcriptional IL-1β cancer cells. This linkage interaction...
Mutations and deletions in components of ubiquitin ligase complexes that lead to alterations protein turnover are important mechanisms driving tumorigenesis. Here we describe an alternative mechanism involving upregulation the microRNA miR-424 leads impaired ubiquitination degradation oncogenic transcription factors prostate cancers. We found targets E3 COP1 identified STAT3 as a key substrate promoting tumorigenic cancer stem-like properties epithelial cells. Altered due function led...
Abstract Although cancer stem-like cells (CSC) are thought to be the most tumorigenic, metastatic, and therapy-resistant cell subpopulation within human tumors, current therapies target bulk tumor while tending spare CSC. In seeking understand mechanisms needed acquire maintain a CSC phenotype in prostate cancer, we investigated connections between ETS transcription factor ESE3/EHF, Lin28/let-7 microRNA axis, this malignancy. normal cells, found that ESE3/EHF bound repressed promoters for...