A5101965768- Lymphoma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- CNS Lymphoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Cardiac tumors and thrombi
- Cancer, Lipids, and Metabolism
- Diabetes Management and Research
- S100 Proteins and Annexins
- Cancer Immunotherapy and Biomarkers
- Cutaneous lymphoproliferative disorders research
- Immune Cell Function and Interaction
- Gastrointestinal Tumor Research and Treatment
- RNA modifications and cancer
- Cancer Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Diabetes and associated disorders
- Colorectal and Anal Carcinomas
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2025
Institute of Oncology Research
2000-2020
Ospedale San Giovanni Bellinzona
1994-2013
Ospedale Santa Chiara
2007
Hôpital Beau-Séjour
2000
University College London
2000
Istituto Cantonale di Patologia
1995-2000
Liceo Cantonale
2000
Università della Svizzera italiana
2000
Policlinico S.Orsola-Malpighi
1998
Objective: To determine the effect of eradicating Helicobacter pylori infection on course low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Design: Prospective cohort study. Setting: University internal medicine clinics, a referral oncology center in southern Switzerland, and gastroenterology northern Italy. Patients: 26 patients with localized primary MALT Intervention: Treatment for H. (bismuth or omeprazole both, amoxicillin, metronidazole 14 days). Main Outcome...
Several lines of evidence suggest a link between chronic gastritis due to Helicobacter pylori and mucosa-associated lymphoid-tissue (MALT) lymphoma the stomach.1,2 A close epidemiologic association has been reported.3–5 The microorganism can be found in gastric mucosa nearly all cases, regression low-grade MALT demonstrated after eradication H. pylori. 6,7 suggested progression from pylori–associated overt lymphoma8 not formally demonstrated, although if it exists, such mechanism may have...
The purpose of this paper is to report the clinical characteristics and treatment outcome following different therapeutic approaches in a large series patients with primary low-grade MALT lymphoma stomach. A total ninety-three (median age 63 years) were reviewed. treated by modalities (local alone, combined treatment, chemotherapy, antibiotics alone); seven refused any treatment. antibiotic-treated group was prospectively followed regular endoscopic biopsies, their responses histologically...
The chromosomal translocation t(11;14)(q13;q32) is the hallmark of mantle cell lymphoma (MCL) in which it can be detected cytogenetically about 75% cases. t(11;14) juxtaposes bcl-1 locus chromosome band 11q13 next to IgH 14q32 and, thus, leads deregulation cycle regulatory protein cyclin D1, encoded by CCND1 gene localized at telomeric border bcl-1-locus. MCL has worst prognosis all low-grade non-Hodgkin's lymphomas (NHL). In some instances, however, histopathologic differentiation between...
Five-year survival in patients with localized prostate cancer (PCa) is nearly 100%, but metastatic disease still remains incurable. Clinical management of has become increasingly complex as novel therapeutic strategies have emerged. This study aims at evaluating the impact first progression on outcome PCa treated curative intent. The analysis was conducted using data 913 cases diagnosed between 2000 and 2014. All were surgery (N = 382) or radiotherapy 531) without adjuvant therapy....
Abstract Background Neuroendocrine markers, which could indicate for aggressive variants of prostate cancer and Ki67 (a well-known marker in oncology defining tumor proliferation), have already been associated with clinical outcome cancer. The aim this study was to investigate the prognostic value those markers primary patients. Patients methods NSE (neuron specific enolase), ChrA (chromogranin A), Syp (Synaptophysin) staining were performed by immunohistochemistry. Then, impact their...
Prostate cancer is the most common type of in men, however, therapeutic options are limited. 50-90% hormone-refractory prostate cells show an overexpression epidermal growth factor receptor (EGFR), which may contribute to uncontrolled proliferation and resistance chemotherapy. In vitro, gefitinib, orally administered tyrosine kinase inhibitor, has shown a significant increase antitumor activity when combined with Patients Methods: this phase II study, safety efficacy gefitinib combination...
The definition of prognostic parameters in early stages gastric lymphoma is still controversial. aim this retrospective analysis was to assess the value stage-modified international index (IPI) predicting outcome a large, consecutive series patients with PGL diffuse large B-cell histology (DLCL).Three hundred twelve consecutive, newly-diagnosed, localized (stages I-IIE according 'Lugano staging system for GI lymphomas') referred from April 1972 December 1997 eight Italian and one Swiss...
Gastric MALT lymphoma usually develops from chronic gastritis, the vast majority of which (>90%) is associated with Helicobacter pylori infection. We sequenced third complementarity determining region (CDR3) immunoglobulin heavy chain genes in 19 gastric clones to determine pattern variable (V), diversity (D) and joining (J) gene utilization during rearrangement. DNA was extracted paraffin‐embedded sections rearranged CDR3 regions were amplified using a semi‐nested polymerase reaction...