A5018291130- Head and Neck Cancer Studies
- Tracheal and airway disorders
- Cancer Treatment and Pharmacology
- Head and Neck Surgical Oncology
- Voice and Speech Disorders
- Colorectal Cancer Treatments and Studies
- Genetics and Neurodevelopmental Disorders
- Reconstructive Surgery and Microvascular Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Ovarian cancer diagnosis and treatment
- Autism Spectrum Disorder Research
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Chemotherapy-induced cardiotoxicity and mitigation
- Melanoma and MAPK Pathways
- Cutaneous lymphoproliferative disorders research
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Chromatin Remodeling and Cancer
- Artificial Intelligence in Healthcare and Education
- Ear and Head Tumors
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Estrogen and related hormone effects
- Histiocytic Disorders and Treatments
- Biochemical Acid Research Studies
Ospedale Policlinico San Martino
2023-2025
University of Genoa
2023-2025
University Hospital of Zurich
2016-2022
University of Zurich
2021
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2013-2017
San Raffaele University of Rome
2014-2016
Ospedale San Luigi Gonzaga
2013
University of Turin
2012
The role of surgery for lung metastases (LM) secondary to colorectal cancer (CRC) remains controversial. bulk evidence is derived from single surgical series, hampering any definitive conclusions. aim this study was compare the outcomes CRC patients with LM submitted those who were not.Data 409 as first advanced disease extracted a database 1,411 patients. Patients divided into three groups: G1, comprised 155 pulmonary and extrapulmonary metastases; G2, 104 only no surgery; G3, 50 surgery.No...
The prognostic value of depth invasion (DOI) in oral squamous cell cancer carcinoma and cutaneous melanoma is well established, while there a lack reports investigating the role DOI laryngeal cancer. This study aims to explore association glottic with other established pathological risk factors nodal metastasis evaluate feasibility measuring preoperatively using tomographic imaging.
Real-time RT-PCR remains a gold standard in the detection of various viral diseases. In coronavirus 2019 pandemic, multiple RT-PCR–based tests were developed to screen for infection. As an emergency response increasing testing demand, we established severe acute respiratory syndrome 2 (SARS-CoV-2) PCR diagnostics platform which compared different commercial and in-house protocols. Four commercial, one customized, protocols evaluated with 92 SARS-CoV-2–positive SARS-CoV-2–negative samples....
Rett syndrome (RTT) is an autism spectrum disorder mainly caused by mutations in the X-linked MECP2 gene and affecting roughly 1 out of 10.000 born girls. Symptoms range severity include stereotypical movement, lack spoken language, seizures, ataxia severe intellectual disability. Notably, muscle tone generally abnormal RTT girls women Mecp2-null mouse model constitutively reflects this disease feature. We hypothesized that MeCP2 might physiologically contribute to its development and/or...
ABSTRACT Background Supraglottic squamous cell carcinoma (SCC) is a significant portion of head and neck cancers, with the management clinically negative necks (cN0) through selective dissection (SND) being debated due to potential morbidities low metastasis rates in levels IIb IV. Methods This study retrospective, multicenter examination feasibility limited (LND), including only IIa III cN0 supraglottic SCC patients. It analyzed occult explored relapse occurrences alongside predictors lymph...
ABSTRACT Background The Vitom Eagle is a novel exoscopic system, specifically designed for transoral surgery (e.g., lateral oropharyngectomy). No prior study has compared it to existing surgical systems. Methods This case report examines patient affected by HPV‐related oropharyngeal squamous cell carcinoma treated with oropharyngectomy using the detailing setup, advantages, and functional outcomes. Results procedure achieved complete tumor resection negative margins. Postoperative recovery...
MECP2 mutations cause a number of neurological disorders which Rett syndrome (RTT) represents the most thoroughly analysed condition. Many Mecp2 mouse models have been generated through years; their validity is demonstrated by presence broad spectrum phenotypes largely mimicking those manifested RTT patients. These models, between C57BL/6 Mecp2tm1.1Bird strain probably used, enabled to disclose much roles Mecp2. However, small litters with little viability and poor maternal care hamper...
One TCGA subgroup of endometrial cancer (EC) is characterised by extensive genomic DNA copy number alterations. CCNE1 located at 19q12 frequently amplified in EC and a target for anti-cancer therapy. The relevance URI, also 19q12, unknown. To evaluate the prevalence (CCNE1/URI) EC, we investigated different histologic types situ hybridisation (ISH) assay. We applied previously established ISH detection CCNE1/URI numbers (n = 270) using conventional bright field microscopy. In subset 21),...
Endometrioid adenocarcinoma of the uterus and ovarian endometrioid carcinoma share many morphological molecular features. Differentiation between simultaneous primary carcinomas metastases an endometrial cancer may be very challenging but is essential for prognostic therapeutic considerations. In present case study a 33 year-old patient we used targeted amplicon next-generation re-sequencing clarifying origin synchronous corpus uteri left ovary. The developed metachronous lung metastasis...
Melanoma currently lacks validated blood-based biomarkers for monitoring and predicting treatment efficacy. Circulating tumor DNA (ctDNA), originating from cells detectable in plasma, has emerged as a possible biomarker patients with metastatic melanoma. In this retrospective, single-center study, we collected 129 plasma samples 79 stage IIIB-IV melanoma determined by the American Joint Committee on Cancer (AJCC, 8th edition). For determination of ctDNA levels, used eight different assays...
Introduction The increasing population of survivors head and neck carcinomas is becoming more conspicuous. Consequently, the pivotal role quality life, particularly elucidated through assessment dysphagia dysphonia, progressively influencing decision-making process. current study aims to assess whether VITOM 3D could offer a comparable post-treatment life traditional approaches for patients with laryngeal cancer oro-hypopharyngeal cancer. Methods A case series treated either an...
Several devices have been developed to improve head and neck surgery. 3D exoscopes provide surgeons a viable alternative microscopes. We propose our setting for transoral exoscopic oropharyngeal (TOEOS) laryngeal surgery (TOELS). A case series of patients treated with the setup at Otolaryngology Unit IRCCS San Martino Hospital, Genoa, is presented. Our surgical oncological outcomes are described. Among 40 undergoing TOELS glottic supraglottic tumours, negative superficial deep margins were...
The management of advanced colorectal cancer patients differs among centers. International guidelines recommend offering all the recognized active regimens in order to obtain survival advantage, but little information is given about sequence and combination which such should be administered.We report case a man with multiple liver metastasis from followed for more than 78 months at our Institution. Repeated response same oxaliplatin, 5-fluorouracil folinic acid chemotherapy schedule was...
9550 Background: Primary analysis results from the phase 2 TRICOTEL study showed intracranial activity with triplet combination of A + C V in pts BRAF V600 -mutated melanoma CNS mets (1). Here, we report final and exploratory biomarker analyses for cohort TRICOTEL. Methods: Eligible were aged ≥18 y had melanoma, MRI-confirmed ≥5 mm ≥1 dimension, no prior systemic treatment metastatic disease. Pts received (840 mg on days 1 15 each 28-d cycle) (60 once daily 21 d on, 7 off) (720 twice daily)...