A5031948038- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Helicobacter pylori-related gastroenterology studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Liver Diseases and Immunity
- Renal Transplantation Outcomes and Treatments
- Eosinophilic Esophagitis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Diverticular Disease and Complications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Multiple and Secondary Primary Cancers
- Polyomavirus and related diseases
- PI3K/AKT/mTOR signaling in cancer
- Gastroesophageal reflux and treatments
- HIV/AIDS drug development and treatment
- Nutrition and Health in Aging
- Herbal Medicine Research Studies
- Drug Solubulity and Delivery Systems
- Dialysis and Renal Disease Management
Ospedale di Bolzano
2023
Azienda Ospedaliero-Universitaria Careggi
2022
University of Florence
2022
Ospedale Sant'Anna
2008-2021
Azienda Ospedaliera S.Maria
2019
Italian Medicines Agency
2018
I.R.C.C.S. Oasi Maria SS
2008-2017
University of Campania "Luigi Vanvitelli"
2016
Associazione Calabrese di Epatologia
2013-2015
University of Naples Federico II
1979-1990
An unexpected increased HCC recurrence and occurrence rate among HCV patients treated with direct acting antivirals combination has been reported. Aim of the study was evaluation early its risk factors in a infected population, direct-acting-antivirals. According to Italian ministerial guidelines for direct-acting-antivirals treatment, 1022 consecutive were enrolled. Patients either active at imaging or history previous HCC, HBV HIV co-infection, liver transplant recipients excluded. The...
In this prospective, multicenter trial, 140 cirrhotic patients with no previous upper gastrointestinal bleeding and esophageal varices endoscopically judged to be at high risk of hemorrhage were randomized receive either sclerotherapy or conservative treatment for the prevention first variceal bleeding. The end-points study death. Life table curves showed that prophylactic significantly diminished incidence (p less than 0.001) overall mortality 0.01). Two-year cumulative rate was 18% in...
Abstract Occult hepatitis B virus (HBV) infection in patients with chronic C has been found associated severe liver damage, low response to interferon treatment and increased risk of developing HCC. However, doubts remain on its clinical impact the sensitivity specificity detection. HBV‐DNA was sought by PCR plasma, peripheral blood mononuclear cells (PBMCs) compartments 89 biopsy proven C, using sets primers for core (“c”), surface (“s”), x (“x”) regions HBV genome. defined presence at...
In 1998, when data of a meta-analysis on tamoxifen in the treatment hepatocellular carcinoma (HCC) had suggested little advantage for this treatment, we published results multicenter randomised controlled trial, that showed no survival benefit vs. control. Here report an updated analysis study 4.5 years after closure enrollment.The planned sample size 480 patients. Patients with any stage HCC were eligible, irrespective locoregional treatment. Tamoxifen was given orally, 40 mg/die, from...
We aim to evaluate in chronic hepatitis B virus-hepatitis C virus (HBV-HCV) coinfection the interplay of these viruses liver tissue, peripheral blood mononuclear cells (PBMC), and plasma analyze effect on disease course response treatment.We enrolled 19 patients with HBV-HCV coinfection, 20 HCV HBV infection at their first biopsy, all were naive for antiviral therapy. The patients' plasma, PBMC biopsy samples tested DNA and/or RNA by real-time PCR, according presence/absence surface antigen...
Liver transplanted patients need close surveillance for early signs of graft disease.Transient elastography can safely be repeated over time, offering serial liver stiffness measurement values. Serial measurements were compared to single baseline in predicting the appearance liver-related clinical events and guiding subsequent decisions.One hundred sixty observed three years our real-life practice.Liver stable 75% patients, decreased 4% increased 21% patients. The pattern was associated with...
Abstract Aim Healthy lifestyle and appropriate diet are of critical importance after liver transplant (LT). We provided an analysis the main patterns physical activity found factors associated with itself. Methods Clinically stable LT recipients were enrolled between June September 2021. Patients completed a composite questionnaire about activity, adherence to Mediterranean Diet (MD), quality life (QoL), employment. Correlations analysed using Pearson coefficients while different subgroups...
Abstract Background and Aim The Barcelona Clinic Liver Cancer (BCLC) algorithm is the standard system for clinical management of hepatocellular carcinoma (HCC). Data on adherence to this therapeutic paradigm are scarce. This field practice study aimed provide a description HCC cirrhotic patients in Southern Italy, evaluate BCLC guidelines its impact patients' survival. Methods We analyzed region‐wide Italian database Progetto Epatocarcinoma Campania , which includes data patients,...
Evidence of relative effectiveness local treatments for hepatocellular carcinoma (HCC) is scanty. We investigated, in a retrospective cohort study, whether surgical resection, radiofrequency ablation (RFA), percutaneous ethanol injection (PEI), and transarterial embolization with (TACE) or without (TAE) chemotherapy resulted different survival clinical practice. All patients first diagnosed HCC treated any locoregional therapy from 1998 to 2002 twelve Italian hospitals were eligible. Overall...
The long-term changes of liver stiffness (LS) in patients who achieve viral clearance after direct-acting anti-HCV therapy remain undefined. We conducted a multicentre prospective study to investigate this aspect. Patients with HCV infection treated DAAs were enrolled from six Italian centres; they underwent clinical, biochemical, ultrasound and transient elastography evaluations before treatment (T0), 12 weeks (SVR12) 24 months (T24) the end therapy. Among 516 consecutive enrolled, 301 had...
Portal vein tumor thrombosis (PVTT) is a common complication of hepatocellular carcinoma and one the most negative prognostic factors. The management patients with PVTT challenging. aim study was to develop score predictive thrombosis.Data from large cohort 2243 (all stages) recorded in Progetto Epatocarcinoma Campania (January 2013-April 2021) database were analyzed. To construct score, univariate generalized estimated equation models, bootstrap approach for internal validation, regression...
De novo malignancies represent an important cause of death for liver transplant recipients. Our aim was to analyze predictors extra-hepatic non-skin cancer (ESNSC) and the impact ESNSC on long-term outcome. We examined data from patients transplanted between 2000 2005 followed-up in five Italian clinics with a retrospective observational cohort study. Cox Regression performed identify ESNSC. A 1:2 sub-study developed 10-year survival. analyzed 367 subjects (median follow-up: 15 years)....
To check the safety and efficacy of boceprevir/telaprevir with peginterferon/ribavirin for hepatitis C virus (HCV) genotype 1 in real-world settings.This study was a non-randomized, observational, prospective, multicenter. This involved 47 centers Italy. A database prepared homogenous collection data, used by all data collection, updated continuously. All patients enrolled this were older than 18 years age diagnosed chronic infection due to HCV 1. The RNA testing performed using...
Liver transplant (LT) patients need regular follow-up both by ultrasonography and elastography. Shear wave elastography is now available in high-end ultrasound systems that, however, may yield different values for any given liver, reflecting technological differences. The aim of this study was to establish whether the point shear QElaXto® (QEpSWE), on Esaote (Genoa, Italy) systems, comparable standard Fibroscan® (vibration-controlled transient elastography, VCTE) real-life setting liver...