A5016456058- Cardiovascular and Diving-Related Complications
- High Altitude and Hypoxia
- Traumatic Brain Injury and Neurovascular Disturbances
- Spaceflight effects on biology
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Health and Disease Prevention
- Erythropoietin and Anemia Treatment
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Cardiovascular and exercise physiology
- Sports Performance and Training
- Blood transfusion and management
- Ocean Acidification Effects and Responses
- Heart Rate Variability and Autonomic Control
- Venous Thromboembolism Diagnosis and Management
- Muscle activation and electromyography studies
- Injury Epidemiology and Prevention
- Cardiac Arrest and Resuscitation
- Sports injuries and prevention
- Intracranial Aneurysms: Treatment and Complications
- Thermoregulation and physiological responses
- Trauma Management and Diagnosis
- Exercise and Physiological Responses
- Hemoglobin structure and function
- Cerebrospinal fluid and hydrocephalus
Haute École de Bruxelles
2016-2024
Vrije Universiteit Brussel
2011-2024
Université Libre de Bruxelles
2010-2024
The Geneva Association
2024
Fondazione Europea Ricerca Biomedica
2023
Universidad de Alcalá
2023
European Research Council
2018-2022
Heritage Malta
2019
Physiol (Belgium)
2018
University Hospital Bonn
2016
The brain’s unique characteristics make it exceptionally susceptible to oxidative stress, which arises from an imbalance between reactive oxygen species (ROS) production, nitrogen (RNS) and antioxidant defense mechanisms. This review explores the factors contributing vascular tone’s vulnerability in presence of damage, can be clinical interest critically ill patients or those presenting acute brain injuries. high metabolic rate inefficient electron transport chain mitochondria lead...
Patency of the foramen ovale (PFO) may be a cause unexplained decompression sickness (DCS) in sports divers. To assess relationship between PFO and DCS, case-control study was undertaken population Belgian Thirty-seven divers who suffered from neurological DCS were compared with matched control never had DCS. All investigated transesophageal contrast echocardiography for presence PFO. size semiquantified on basis amount passage. Divers lesions localized high cervical spinal cord, cerebellum,...
To investigate whether the intensity and duration of a sustained contraction influences reflex regulation, we compared fatiguing contractions at 25 % 50 maximal voluntary (MVC) force in human abductor pollicis brevis (APB) muscle. Because activation motoneurones during fatigue may be reflexively controlled by metabolic status muscle, also activities intermittent (6 s contraction, 4 rest) MVC for an identical duration. The short‐latency Hoffmann(H) long‐latency (LLR) were recorded...
Decompression sickness (DCS) is a systemic disorder, assumed due to gas bubbles, but additional factors are likely play role. Circulating microparticles (MPs)—vesicular structures with diameters of 0.1-1.0 μm—have been implicated, data in human divers have lacking. We hypothesized that the number blood-borne, Annexin V-positive MPs and neutrophil activation, assessed as surface MPO staining, would differ between self-contained underwater breathing-apparatus suffering from DCS vs....
The term “normobaric oxygen paradox” (NOP), describes the response to return normoxia after a hyperoxic event, sensed by tissues as shortage, and resulting in up-regulation of Hypoxia-inducible factor 1α (HIF-1α) transcription activity. molecular characteristics this have not been yet fully characterized. Herein, we report activation time trend oxygen-sensitive factors human peripheral blood mononuclear cells (PBMCs) obtained from healthy subjects one hour exposure mild (MH), high (HH) very...
Hyperbaric oxygen therapy (HBOT) is a therapeutical approach based on exposure to pure in an augmented atmospheric pressure. Although it has been used for years, the exact kinetics of reactive species (ROS) between different pressures hyperbaric are still not clearly evidenced. In this study, metabolic responses hyperoxia exposures 1 h at 1.4 and 2.5 ATA were investigated. Fourteen healthy non-smoking subjects (2 females 12 males, age: 37.3 ± 12.7 years old (mean SD), height: 176.3 9.9 cm,...
Blood-borne extracellular vesicles and inflammatory mediators were evaluated in divers using a closed circuit rebreathing apparatus custom-mixed gases to diminish some diving risks. “Deep” (n = 8) dove once mean (±SD) 102.5 ± 1.2 m of sea water (msw) for 167.3 11.5 min. “Shallow” 6) 3 times on day 1, then repetitively over 7 days 16.4 3.7 msw, 49.9 11.9 There statistically significant elevations microparticles (MPs) deep (day 1) shallow at that expressed proteins specific microglia,...
The “normobaric oxygen paradox” (NOP) describes the response to return normoxia after a hyperoxic event, sensed by tissues as an shortage, up-regulating redox-sensitive transcription factors. We have previously characterized time trend of oxygen-sensitive factors in human PBMCs, which 30% is hypoxic trigger, hypoxia-induced factor (HIF-1) activation. On contrary, 100% and 140% induce shift toward oxidative stress response, NRF2 NF-kB activation first 24 h post exposure. Herein, we...
It has been proposed that relative changes of oxygen availability, rather than steady-state hypoxic or hyperoxic conditions, play an important role in hypoxia-inducible factor (HIF) transcriptional effects. According to this hypothesis describing the “normobaric paradox”, normoxia following a event is sensed by tissues as shortage, upregulating HIF-1 activity. With aim confirming, at cellular and functional level, “interpreted” event, we report combination experiments addressing effects...
Introduction: The popularity of SCUBA diving is steadily increasing together with the number dives and correlated diseases per year. rules that govern correct decompression procedures are considered well known even if majority Decompression Sickness (DCS) cases unexpected confirming a bias in "mathematical ability" to predict DCS by current algorithms. Furthermore, little still about risk factors any individual predisposition DCS. This study provides an in-depth epidemiological analysis...
Exercise generates reactive oxygen species (ROS), creating a redox imbalance towards oxidation when inadequately intense. Normobaric and hyperbaric (HBO) breathed while not exercising induces antioxidant enzymes expression, but literature is still poor. Twenty-two athletes were assigned to five groups: controls; 30%, or 50% O2; 100% O2 at 1.5 2.5 atmosphere absolute (ATA). Twenty treatments administered on non-training days. Biological samples collected T0 (baseline), T1 (end of treatments),...
Oxygen is a powerful trigger for cellular reactions, but there are few comparative investigations assessing the effects over large range of partial pressures. We investigated metabolic response to single exposures either normobaric (10%, 15%, 30%, 100%) or hyperbaric (1.4 ATA, 2.5 ATA) oxygen. Forty-eight healthy subjects (32 males/16 females; age: 43.7 ± 13.4 years, height: 172.7 10.07 cm; weight 68.4 15.7 kg) were randomly assigned, and blood samples taken before 2 h after each exposure....
Renal (peritubular) tissue hypoxia is a well-known physiological trigger for erythropoietin (EPO) production. We investigated the effect of rebound relative after hyperoxia obtained under normo- and hyperbaric oxygen breathing conditions. A group 16 healthy volunteers were before period 100% normobaric 2 h at 2.5 ATA 90 min (hyperbaric oxygen). Serum EPO concentration was measured using radioimmunoassay various time points during 24-36 h. 60% increase (P < 0.001) in serum observed 36 oxygen....
Transcutaneous neurostimulation (TNS) at extracephalic sites is a well known treatment of pain. Thanks to recent technical progress, the Cefaly® device now also allows supraorbital TNS. During observational clinical studies, several patients reported decreased vigilance or even sleepiness during session We decided therefore explore in more detail potential sedative effect TNS, using standardized psychophysical tests healthy volunteers. performed double-blind cross-over sham-controlled study...
Inflammation is an adaptive response to both external and internal stimuli including infection, trauma, surgery, ischemia-reperfusion, or malignancy. A number of studies indicate that physical activity effective means reducing acute systemic low-level inflammation occurring in different pathological conditions the recovery phase after disease. As a proof-of-principle, we hypothesized low-intensity workout performed under modified oxygen supply would elicit "metabolic exercise" inducing...
We aimed to evaluate the feasibility of an online High-Intensity Interval Training (HIIT) program on clinical psychological symptoms in higher education students context COVID-19 pandemic lockdown.