A5030924904- Cardiovascular and Diving-Related Complications
- High Altitude and Hypoxia
- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma Management and Diagnosis
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Health and Disease Prevention
- Diabetic Foot Ulcer Assessment and Management
- Cardiac Arrest and Resuscitation
- Intracranial Aneurysms: Treatment and Complications
- Injury Epidemiology and Prevention
- Ocean Acidification Effects and Responses
- Respiratory Support and Mechanisms
- Erythropoietin and Anemia Treatment
- Restraint-Related Deaths
- Infection Control and Ventilation
- Cerebrospinal fluid and hydrocephalus
- Hemodynamic Monitoring and Therapy
- Atrial Fibrillation Management and Outcomes
- Glaucoma and retinal disorders
- Blood transfusion and management
- Spaceflight effects on biology
- Cancer, Hypoxia, and Metabolism
- Obstructive Sleep Apnea Research
- Heart Rate Variability and Autonomic Control
- Cardiac tumors and thrombi
Queen Astrid Military Hospital
2015-2024
Haute École de Bruxelles
2017-2024
European Research Council
2020
Heritage Malta
2019
Organogenesis (United States)
2013
École Normale Supérieure - PSL
2012
Military Hospital
1998-2011
Patency of the foramen ovale (PFO) may be a cause unexplained decompression sickness (DCS) in sports divers. To assess relationship between PFO and DCS, case-control study was undertaken population Belgian Thirty-seven divers who suffered from neurological DCS were compared with matched control never had DCS. All investigated transesophageal contrast echocardiography for presence PFO. size semiquantified on basis amount passage. Divers lesions localized high cervical spinal cord, cerebellum,...
Decompression sickness (DCS) is a systemic disorder, assumed due to gas bubbles, but additional factors are likely play role. Circulating microparticles (MPs)—vesicular structures with diameters of 0.1-1.0 μm—have been implicated, data in human divers have lacking. We hypothesized that the number blood-borne, Annexin V-positive MPs and neutrophil activation, assessed as surface MPO staining, would differ between self-contained underwater breathing-apparatus suffering from DCS vs....
Patent foramen ovale (PFO) is implicated in the pathogenesis of a number medical conditions but to date only one official position paper related left circulation thromboembolism has been published. This interdisciplinary paper, prepared with involvement eight European scientific societies, reviews available evidence and proposes rationale for decision making other PFO-related clinical conditions. In order guarantee strict evidence-based process, we used modified grading recommendations,...
The term “normobaric oxygen paradox” (NOP), describes the response to return normoxia after a hyperoxic event, sensed by tissues as shortage, and resulting in up-regulation of Hypoxia-inducible factor 1α (HIF-1α) transcription activity. molecular characteristics this have not been yet fully characterized. Herein, we report activation time trend oxygen-sensitive factors human peripheral blood mononuclear cells (PBMCs) obtained from healthy subjects one hour exposure mild (MH), high (HH) very...
Hyperbaric oxygen therapy (HBOT) is a therapeutical approach based on exposure to pure in an augmented atmospheric pressure. Although it has been used for years, the exact kinetics of reactive species (ROS) between different pressures hyperbaric are still not clearly evidenced. In this study, metabolic responses hyperoxia exposures 1 h at 1.4 and 2.5 ATA were investigated. Fourteen healthy non-smoking subjects (2 females 12 males, age: 37.3 ± 12.7 years old (mean SD), height: 176.3 9.9 cm,...
It has been proposed that relative changes of oxygen availability, rather than steady-state hypoxic or hyperoxic conditions, play an important role in hypoxia-inducible factor (HIF) transcriptional effects. According to this hypothesis describing the “normobaric paradox”, normoxia following a event is sensed by tissues as shortage, upregulating HIF-1 activity. With aim confirming, at cellular and functional level, “interpreted” event, we report combination experiments addressing effects...
Oxygen is a powerful trigger for cellular reactions, but there are few comparative investigations assessing the effects over large range of partial pressures. We investigated metabolic response to single exposures either normobaric (10%, 15%, 30%, 100%) or hyperbaric (1.4 ATA, 2.5 ATA) oxygen. Forty-eight healthy subjects (32 males/16 females; age: 43.7 ± 13.4 years, height: 172.7 10.07 cm; weight 68.4 15.7 kg) were randomly assigned, and blood samples taken before 2 h after each exposure....
Renal (peritubular) tissue hypoxia is a well-known physiological trigger for erythropoietin (EPO) production. We investigated the effect of rebound relative after hyperoxia obtained under normo- and hyperbaric oxygen breathing conditions. A group 16 healthy volunteers were before period 100% normobaric 2 h at 2.5 ATA 90 min (hyperbaric oxygen). Serum EPO concentration was measured using radioimmunoassay various time points during 24-36 h. 60% increase (P < 0.001) in serum observed 36 oxygen....
Inflammation is an adaptive response to both external and internal stimuli including infection, trauma, surgery, ischemia-reperfusion, or malignancy. A number of studies indicate that physical activity effective means reducing acute systemic low-level inflammation occurring in different pathological conditions the recovery phase after disease. As a proof-of-principle, we hypothesized low-intensity workout performed under modified oxygen supply would elicit "metabolic exercise" inducing...
In this study, the metabolic responses of hypoxic breathing for 1 h to inspired fractions 10% and 15% oxygen were investigated. To end, 14 healthy nonsmoking subjects (6 females 8 males, age: 32.2 ± 13.3 years old (mean SD), height: 169.1 9.9 cm, weight: 61.6 16.2 kg) volunteered study. Blood samples taken before, at 30 min, 2 h, 24 48 after a exposure. The level oxidative stress was evaluated by considering reactive species (ROS), nitric oxide metabolites (NOx), lipid peroxidation,...
Oxygen is a powerful trigger for cellular reactions and used in many pathologies, including oxidative stress. However, the effects of oxygen over time at different partial pressures remain poorly understood. In this study, metabolic responses normobaric intake 1 h to mild (30%) high (100%) inspired fractions were investigated. Fourteen healthy non-smoking subjects (7 males 7 females; age: 29.9 ± 11.1 years, height: 168.2 9.37 cm; weight: 64.4 12.3 kg; BMI: 22.7 4.1) randomly assigned two...
We investigated long‐term effects of SCUBA diving on cognitive function using a battery neuropsychometric tests: the S imple R eaction T ime ( REA ), ymbol D igit ubstitution SDS pan B ackwards DSB and H and‐ E ye C oordination tests EYE ). A group n = 44) experienced divers with no history decompression sickness was compared to non‐diving control subjects 37), as well professional boxers 24), who are considered at higher risk long term neurological damage. The significantly shorter in...
In situ evaluation of human brain performance and arousal remains challenging during operational circumstances, hence the need for a rapid, reliable reproducible tool. Here we hypothesized that Critical flicker fusion frequency (CFFF) reflecting/requiring visual integration, visuo-motor skills decision-taking process might be powerful, fast simple tool in modified gravity environments. Therefore 11 male healthy volunteers were assessed higher cognitive functions with CFFF parabolic flights....
Introduction: The “Severe Acute Respiratory Syndrome Coronavirus 2″ (SARS-CoV2) pandemic has led to a worldwide shortage of personal protection devices (PPD) for medical and paramedical personnel. Adaptation commercially available snorkel masks serve as full face been proposed. Even not formally approved PPD, they are publicized on social media suitable this use. Concerns about actual levels risk carbon dioxide (CO2) accumulation while wearing them extended periods made us perform systematic...
Patent foramen ovale (PFO) is implicated in the pathogenesis of a number medical conditions but to date only one official position paper related left circulation thromboembolism has been published. This interdisciplinary paper, prepared with involvement eight European scientific societies, reviews available evidence and proposes rationale for decision making other PFO-related clinical conditions. In order guarantee strict evidence-based process, we used modified grading recommendations,...
INTRODUCTION: Future high-altitude military operations and spaceflight will require new procedures to protect crews from decompression sickness while limiting the operational impact. It is hypothesized that current prediction models do not accurately reflect actual inert gas dynamics, making them unsuitable for risk estimation of hypobaric exposure profiles. METHODS: A biophysical exchange model was created, allowing modification various physiological parameters. Predicted nitrogen (N 2 )...
This study investigated the influence of a far infrared-ray dry sauna-induced heat exposure before simulated dive on bubble formation, and examined concomitant adjustments in hemodynamic parameters.There were 16 divers who compressed hyperbaric chamber to 400 kPa (30 msw) for 25 min decompressed at 100 x min(-1) with 4-min stop 130 kPa. Each diver performed two dives 5 d apart, one without predive sauna session 30 65 degrees C ending 1 h prior dive. Circulating venous bubbles detected...