A5052298059- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Electrospun Nanofibers in Biomedical Applications
- Gastrointestinal Tumor Research and Treatment
- Bone Tissue Engineering Materials
- Heat and Mass Transfer in Porous Media
- Gastric Cancer Management and Outcomes
- Tissue Engineering and Regenerative Medicine
- Groundwater flow and contamination studies
- Cancer-related molecular mechanisms research
- Periodontal Regeneration and Treatments
- Cutaneous Melanoma Detection and Management
- Skin Protection and Aging
- Exercise and Physiological Responses
- Silk-based biomaterials and applications
- High Altitude and Hypoxia
- Advanced Biosensing Techniques and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Veterinary Orthopedics and Neurology
- Asthma and respiratory diseases
- Sarcoma Diagnosis and Treatment
- Anatomy and Medical Technology
- Laser Applications in Dentistry and Medicine
- Inflammasome and immune disorders
University of Ferrara
1995-2024
Albert Einstein College of Medicine
2024
University of Bologna
1984-2022
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2010
Skin ageing is strictly related to chronic inflammation of the derma and decay structural proteins extracellular matrix. Indeed, it has become common practice refer this phenomenon as inflammageing. Biotech innovation always in search new active principles that induce a youthful appearance. In paper, apple-derived nanovesicles (ADNVs) were investigated novel anti-inflammatory compounds, which are able alter matrix production dermal fibroblasts. Total RNA sequencing analysis revealed ADNVs...
The constant dialogue between the plant world and animal (including man among them) has been known since time of Adam Eve, where an apple was origin evils world. Apart from Snow White-who might have something to object when it comes use apples-fruits, plants, natural extracts for millennia as remedies human health-related ailments. In light such evidence, aim present work investigate a biological point view potential role exosomes in inflammatory processes on cells. To this end we isolated...
Background Aneuploidy occurs in more than 20% of acute myeloid leukemia (AML) cases and correlates with an adverse prognosis. Methods To understand the molecular bases aneuploid (A‐AML), this study examined genomic profile 42 A‐AML 35 euploid (E‐AML) cases. Results was characterized by increased complexity based on exonic variants (an average 26 somatic mutations per sample vs 15 for E‐AML). The integration exome, copy number, gene expression data revealed alterations genes involved DNA...
Exercise generates reactive oxygen species (ROS), creating a redox imbalance towards oxidation when inadequately intense. Normobaric and hyperbaric (HBO) breathed while not exercising induces antioxidant enzymes expression, but literature is still poor. Twenty-two athletes were assigned to five groups: controls; 30%, or 50% O2; 100% O2 at 1.5 2.5 atmosphere absolute (ATA). Twenty treatments administered on non-training days. Biological samples collected T0 (baseline), T1 (end of treatments),...
Several factors, such as ischemia, infection and skin injury impair the wound healing process. One common pathway in all these processes is related to reactive oxygen species (ROS), whose production plays a vital role healing. In this view, several strategies have been developed stimulate activation of antioxidative system, thereby reducing damage oxidative stress improving For purpose, complex magnetic fields (CMFs) are used work on fibroblast monocyte cultures derived from diabetic...
Plant-derived nanovesicles (PDNVs) are a novelty in medical and agrifood environments, with several studies exploring their functions potential applications. Among fruits, apples (sp. Malus domestica) have great as PDNVs source, given widespread consumption, substantial waste production, recognized health benefits. Notably, apple-derived (ADNVs) can interact human cell lines, triggering anti-inflammatory antioxidant responses. This work is dedicated to the comprehensive biochemical...
Gastric cancer (GC) is the fifth most prevalent worldwide and third leading cause of global mortality. With advances omic studies, a heterogeneous GC landscape has been revealed, with significant molecular diversity. Given multifaceted nature GC, identification different patient subsets prognostic and/or predictive outcomes key aspect to allow tailoring specific treatments. Recently, involvement microbiota in gastric carcinogenesis described. To deepen this aspect, we compared composition...
Background: Electrospun fibers have attracted a lot of attention from researchers due to their several characteristics, such as very thin diameter, three-dimensional topography, large surface area, flexible surface, good mechanical suitable for widespread applications. Indeed, electro-spinning offers many benefits, great surface-to-volume ratio, adjustable porosity, and the ability imitating tissue extra-cellular matrix. Methods: we processed Poly ε-caprolactone (PCL) via electrospinning...
Craniofacial tissue reconstruction still represents a challenge in regenerative medicine. Mesenchymal stem cell (MSC)-based engineering strategies have been introduced to enhance bone repair. However, the risk of related complications is limiting their usage. To overcome these drawbacks, exosomes (EXOs) derived from MSCs recently proposed as cell-free alternative direct regeneration. It was hypothesized that there correlation between biological properties dental pulp and age donor. The aim...
A challenge in contractile restoration of myocardial scars is one the principal aims cardiovascular surgery. Recently, a new potent biological tool used within healing processes represented by exosomes derived from mesenchymal stem cells (MSCs). These are well-known extracellular nanovesicles released to facilitate cell function and communication. In this work, combination elastomeric membranes was obtained tested as bioimplant. Mesenchymal (MSCs) macrophages were seeded into scaffold...
Small extracellular vesicles (sEVs) derived from mesenchymal stem cells (MSCs) have attracted growing interest as a possible novel therapeutic agent for the management of different cardiovascular diseases (CVDs). Hypoxia significantly enhances secretion angiogenic mediators MSCs well sEVs. The iron-chelating deferoxamine mesylate (DFO) is stabilizer hypoxia-inducible factor 1 and consequently used substitute environmental hypoxia. improved regenerative potential DFO-treated has been...
(1) Background: Implantation of metal-based scaffolds is a common procedure for treating several diseases. However, the success long-term application limited by an insufficient endothelialization material surface. Nanostructured modifications metal represent promising approach to faster biomaterial osteointegration through increasing endothelial commitment mesenchymal stem cells (MSC). (2) Methods: Three different nanotubular Ti surfaces (TNs manufactured electrochemical anodization with...
In dentistry, bone regeneration requires osteoinductive biomaterial with antibacterial properties. Polycaprolactone (PCL) may be combined different nanofillers including reduced graphene oxide (rGO). Here, the amount of rGO filler was defined to obtain a biocompatible and PCL-based surface supporting adhesion differentiation human mesenchymal stem cells (MSCs). Compounds carrying three percentages were tested. Among all, 5% rGO-PCL compound is most bacteriostatic against Gram-positive...
Exposure to microgravity (μg) results in a range of systemic changes the organism, but may also have beneficial cellular effects. In previous study we detected increased proliferation capacity and upregulation genes related survival boundary cap neural crest stem cells (BC) after MASER14 sounding rocket flight compared ground-based controls. However, whether these were due μg or hypergravity was not clarified. current MASER15 experiment BCs exposed simultaneously 1 g conditions provided by...
The aim of this in vitro study was to investigate the commitment and behavior dental pulp stem cells (DPSCs) seeded onto two different grafting materials, human dentin particulate (DP) deproteinized bovine bone matrix (BG), with those cultured absence supplements. Gene expression analyses along epigenetic morphological tests were carried out examine odontogenic osteogenic differentiation cell proliferation. Compressive testing materials DPSCs performed as well. DPSC into odontoblast-like...
Summary We studied the involvement of oxidative stress in chronic idiopathic urticaria (CIU), assessing activities superoxide dismutase (SOD) and glutathione levels malondialdeyde (MDA), a marker lipid peroxidation, samples taken from lesional skin (n = 16) nonlesional 11) CIU patients. The activity SOD MDA were markedly increased as compared with healthy subjects, whereas no differences detected between patients control samples. Immuno‐dot blot assay revealed an up‐regulation Mn‐SOD...
Preclinical forms of gastrointestinal stromal tumor (GIST), small asymptomatic lesions, called microGIST, are detected in approximately 30% the general population. Gastrointestinal driver mutation can be already microGISTs, even if they do not progress into malignant cancer; these mutations necessary, but insufficient events to foster progression. Here we profiled tissue microbiota 60 specimens three different patient cohorts-micro, low-risk, and high-risk or metastatic GIST-exploring...
Aortic valve stenosis has become the most common valvular disease in elderly patients. Several treatments are available such as surgical aortic replacement and transcatheter implantation. To date, however, there is a need to discover alternative that can delay progression and, therefore, implant of prosthetic valve. In this regard, decalcification procedure based on use ultrasonic waves could represent an innovative solution cardiovascular therapies. article, we describe debridement device...