A5030107487- Diabetes Treatment and Management
- Angiogenesis and VEGF in Cancer
- Diabetic Foot Ulcer Assessment and Management
- Diabetes Management and Research
- Chronic Kidney Disease and Diabetes
- Blood Pressure and Hypertension Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Mesenchymal stem cell research
- Liver Disease Diagnosis and Treatment
- Peripheral Artery Disease Management
- Diet and metabolism studies
- Coronary Interventions and Diagnostics
- Metabolism, Diabetes, and Cancer
- Heart Rate Variability and Autonomic Control
- Electrolyte and hormonal disorders
- Ovarian function and disorders
- Renal and Vascular Pathologies
- Lipid metabolism and disorders
- Planarian Biology and Electrostimulation
- Pain Mechanisms and Treatments
- Cardiovascular Function and Risk Factors
- CCD and CMOS Imaging Sensors
- Diabetes Management and Education
- Laser Applications in Dentistry and Medicine
- Nerve injury and regeneration
Ca' Foncello Hospital
2014-2024
Local Government Association
2021
Boart Longyear (United States)
2019
Treviso Tecnologia (Italy)
2019
Ospedaliero di Castelfranco Veneto
2018
University of Padua
1991-2015
Azienda ULSS 9 TREVISO
2014
University of Modena and Reggio Emilia
2005
University of Milan
2005
University of Catania
2000-2005
Heterogeneity in renal structure has been described type 2 diabetic patients with both microalbuminuria and proteinuria; fact, only a subset of have the typical glomerulopathy. However, it is currently unknown whether abnormalities albumin excretion rate (AER) different prognostic value depending on underlying structure. Aims this study were: 1) to course function altered AER; 2) evaluate relationship between glomerular filtration (GFR) structure; 3) GFR baseline AER levels, metabolic...
Mutations in LPL or APOC2 genes are recognized causes of inherited forms severe hypertriglyceridemia. However, some hypertrigliceridemic patients do not have mutations either these genes. Because inactivation hyperexpression APOA5 gene, encoding apolipoprotein A-V (apoA-V), a marked increase decrease plasma triglycerides mice, and because common polymorphisms this gene affect humans, we hypothesized that loss function might cause hypertriglyceridemia.We sequenced 10 hypertriglyceridemic whom...
Fat accumulates in bone marrow (BM) of patients with diabetes. In this study, we investigated the mechanisms and consequences phenomenon. BM mesenchymal stromal cells (BM-MSCs) from type 2 diabetes (T2D) constitutively express adipogenic markers robustly differentiate into adipocytes (ADs) upon vitro induction as compared BM-MSCs subjects without Moreover, BM-ADs T2D (T2D BM-ADs) paracrinally stimulate a transcriptional program BM-MSCs. Antagonism MCP-1, chemokine pivotally expressed BM-ADs,...
OBJECTIVE The effects of preventive interventions on cardiovascular autonomic neuropathy (CAN) remain unclear. We examined the effect intensively treating traditional risk factors for CAN, including hyperglycemia, hypertension, and dyslipidemia, in individuals with type 2 diabetes (T2D) high participating Action to Control Cardiovascular Risk Diabetes (ACCORD) trial. RESEARCH DESIGN AND METHODS CAN was defined as heart rate variability indices below fifth percentile normal distribution. Of...
The minimal model is widely used to evaluate insulin action on glucose disappearance from frequently sampled intravenous tolerance tests (FSIGT). common protocols are a regular (rFSIGT, single injection of 0.3 g/kg glucose) and an insulin-modified test (mFSIGT, with additional administration at 20 min). This study compared the sensitivity index (S I ) effectiveness G obtained in same individual (16 normal subjects) two tests. S was 7.11 ± 0.80 10 −4 ⋅ min −1 μU ml rFSIGT 6.96 0.83 mFSIGT ( P...
Journal Article Treatment of anovulation with pulsatile gonadotropin-releasing hormone: prognostic factors and clinical results in 600 cycles Get access M Filicori, Filicori 1Reproductive Endocrinology Center, University Bologna, Italy. Search for other works by this author on: Oxford Academic Google Scholar C Flamigni, Flamigni P Dellai, Dellai G Cognigni, Cognigni L Michelacci, Michelacci R Arnone, Arnone Sambataro, Sambataro A Falbo The Clinical & Metabolism, Volume 79, Issue 4, 1 October...
Several factors, such as ischemia, infection and skin injury impair the wound healing process. One common pathway in all these processes is related to reactive oxygen species (ROS), whose production plays a vital role healing. In this view, several strategies have been developed stimulate activation of antioxidative system, thereby reducing damage oxidative stress improving For purpose, complex magnetic fields (CMFs) are used work on fibroblast monocyte cultures derived from diabetic...
Previous studies have shown that diabetes mellitus destabilises the integrity of microvasculature in different organs by damaging interaction between pericytes and endothelial cells. In bone marrow, exert trophic functions on cells haematopoietic through paracrine mechanisms. However, whether marrow are a target diabetes-induced damage remains unknown. Here, we investigated type 2 can affect abundance function pericytes. We conducted an observational clinical study comparing...
It has not yet been fully clarified whether the plasma or renal clearance approach is most reliable to investigate GFR in humans. The study presented here aimed compare decay with of 51Cr-EDTA 27 diabetic patients patterns function broadly dispersed a wide range values. Moreover, comparison was also performed nonlabeled iothalamate subgroup 17 patients. A biexponential found fulfill statistical and heuristic criteria for modeling analysis 19 samples after bolus intravenous injection....
Insulin resistance may be a mechanism linking non-insulin-dependent diabetes mellitus (NIDDM) to hypertension and cardiovascular mortality. Microalbuminuria also is an independent risk factor of mortality hypertension. Little information available in the literature on relationship between microalbuminuria insulin action. This study investigated relationships blood pressure (BP) levels, microalbuminuria, NIDDM patients. Seventy-five patients attending outpatient clinic Department Internal...
Upon tissue injury, peripheral sensory neurons release nociceptive factors (e.g. substance P [SP]), which exert local and systemic actions including the recruitment of bone marrow (BM)-derived haematopoietic stem progenitor cells (HSPCs) endowed with paracrine pro-angiogenic properties. We herein explore whether diabetic neuropathy interferes these phenomena. first investigated presence in BM patients type 2 diabetes by immunohistochemistry morphometry analyses nerve size density assessment...
The aim of this study was to investigate the relationships among insulin resistance and albumin excretion rate in 25 nondiabetic patients with essential hypertension 28 non-insulin dependent diabetes mellitus (NIDDM). Two groups healthy subjects matched for age, sex, weight served as controls. Patients were divided into two subgroups: without (H1) (H2) microalbuminuria. Diabetic four those normoalbuminuria (NIDDM1) (NIDDM2) microalbuminuria (NIDDM3) (NIDDM4) hypertension. Whole-body glucose...
OBJECTIVE In patients with type 2 diabetes (T2D) and critical limb ischemia (CLI), migration of circulating CD34+ cells predicted cardiovascular mortality at 18 months after revascularization. This study aimed to provide long-term validation mechanistic understanding the biomarker. RESEARCH DESIGN AND METHODS The association between cell was reassessed 6 years a new series T2D-CLI control subjects, immuno-sorted bone marrow were profiled for miRNA expression assessed apoptosis angiogenesis...
<p>Diabetic foot ulcers (DFUs) often result in severely adverse outcomes, such as serious infections, hospitalization, and lower extremity amputations. In last few years, to improve the outcome of DFUs, clinicians researchers put their attention on application low intensity pulsating electro-magnetic fields through Therapeutic Magnetic Resonance (TMR<sup>®</sup>). our study, patients with DFUs have been divided into two groups: The Sham Group treated non-functioning...
Achieving glycemic target is paramount to control diabetes mellitus (DM) and reduce micro-vascular macro-vascular complications. Despite the mostly recent-developed drugs, most patients still show an above desired glycated hemoglobin (HbA1c) level due DM complex pathophysiology, therapeutic dietary compliance clinical inertia in introducing or intensifying insulin therapy. To support promising results of trials on effectiveness safety degludec/liraglutide combination (IDegLira) type 2 with...
Therapeutic education for Type 1 Diabetes involves the process of transmitting knowledge and developing skills behavior required to treat disease. guidelines agree on stressing importance therapeutic educational intervention in teaching self-management children adolescents with (T1D). This study presents results "Pediatric Education (T1D)" (PED) project, specifically designed aged 6 16, structured indications, as part a broader clinical-educational diabetes.Twenty-four patients diabetes...
Objective. We studied circulating precursor cells (CPC) in type 2 diabetes mellitus (T2DM) with neuropathic foot lesions or without critical limb ischemia and relationships between endothelial (EPC) peripheral neuropathy. Methods Subjects. measured blood CD34, CD133, CD45 markers for CPC KDR, CD31 EPC by citofluorimetry systemic neural nociceptor CGRP (calcitonin gene related protein) ELISA 8 healthy controls (C) 62 T2DM patients: 14 neuropathy (N), 20 (N1), 28 neuroischemic recent...
Objective: To test the efficacy and safety of therapeutic magnetic resonance (TMR) in management diabetic foot ulcers (DFU), authors designed a prospective randomised controlled trial three highly specialised clinics. Method: All patients consecutively visited period 18 months were screened according to inclusion (presence an ulcer >1 cm 2 lasting at least 6 weeks; ABPI>0.6; consent participate study) exclusion (Charcot's foot; local or systemic infections; chronic renal failure; any...
Thymic carcinoma is exceptionally rare in children and it has never previously been associated with autoimmune disorders. The authors report the case of an 11-year-old boy thymic carcinoma, hypertrophic pulmonary osteoarthropathy, disease that resembled systemic lupus erythematosus. To their knowledge, this first such complex clinical findings. tumor was high grade histologically died after 1 year, spite chemotherapy radiotherapy. A review presented available medical literature on malignancy...