A5103054636- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- Autophagy in Disease and Therapy
- Heart Rate Variability and Autonomic Control
- Drug Transport and Resistance Mechanisms
- Blood Pressure and Hypertension Studies
- Calpain Protease Function and Regulation
- Pancreatic function and diabetes
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Syncope and Autonomic Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Parkinson's Disease Mechanisms and Treatments
- Cardiovascular and exercise physiology
- Cancer, Lipids, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Lipoproteins and Cardiovascular Health
- Diabetes Treatment and Management
- Pain Mechanisms and Treatments
- Diabetes Management and Research
- Salivary Gland Tumors Diagnosis and Treatment
- Animal Vocal Communication and Behavior
- Heart rate and cardiovascular health
- Animal Behavior and Reproduction
- Cardiovascular Function and Risk Factors
University of South China
2014-2025
Joslin Diabetes Center
2019-2024
Harvard University
2019-2024
Southwest Petroleum University
2023
University Medical Center Groningen
2023
West China Hospital of Sichuan University
2023
Sichuan University
2022-2023
Xiangya Hospital Central South University
2022
Central South University
2022
Ann Arbor Center for Independent Living
2021
Abstract Background Neuronal ferroptosis plays a critical role in the pathogenesis of cognitive deficits. The present study explored whether artemisinin protected type 2 diabetes mellitus (T2DM) mice from impairments by attenuating neuronal hippocampal CA1 region. Methods STZ-induced T2DM were treated with (40 mg/kg, i.p.), or cotreated and Nrf2 inhibitor MEL385 inducer erastin for 4 weeks. Cognitive performance was determined Morris water maze Y tests. Hippocampal ROS, MDA, GSH, Fe 2+...
OBJECTIVE The effects of preventive interventions on cardiovascular autonomic neuropathy (CAN) remain unclear. We examined the effect intensively treating traditional risk factors for CAN, including hyperglycemia, hypertension, and dyslipidemia, in individuals with type 2 diabetes (T2D) high participating Action to Control Cardiovascular Risk Diabetes (ACCORD) trial. RESEARCH DESIGN AND METHODS CAN was defined as heart rate variability indices below fifth percentile normal distribution. Of...
Epigallocatechin gallate (EGCG) is a major polyphenol in green tea with beneficial effects on the impairment learning and memory. Autophagy cellular process that protects neurons from stressful conditions. The present study was designed to investigate whether EGCG can rescue chronic unpredictable mild stress (CUMS)-induced cognitive rats its protective effect involves improvement of autophagic flux. As expected, our results showed CUMS significantly impaired memory performance inhibited flux...
Our previous studies have indicated that a novel curcumin derivate nicotinate-curcumin (NC) has beneficial effects on the prevention of atherosclerosis, but precise mechanisms are not fully understood. Given autophagy regulates lipid metabolism, present study was designed to investigate whether NC decreases foam cell formation through restoring flux in oxidized low-density lipoprotein (ox-LDL)-treated THP-1 cells. results showed ox-LDL (100 μg/ml) accumulated cells and impaired flux....
Genetic factors have been postulated to be involved in the etiology of diabetic peripheral neuropathy (DPN), but their identity remains mostly unknown. The aim this study was conduct a systematic search for genetic variants influencing DPN risk using two well-characterized cohorts. A genome-wide association (GWAS) testing 6.8 million single nucleotide polymorphisms conducted among participants Action Control Cardiovascular Risk Diabetes (ACCORD) clinical trial. Included were 4,384 white case...
Background: Although our previous studies have confirmed that the activation of TLR4 is implicated in development atherosclerosis induced by chronic unpredicted mild stress (CUMS), underling mechanism largely unclear. Here, we hypothesized CUMS accelerates atherosclerotic through lowering PPARγ/LXRα-ABCA1 expression via HMGB1/TLR4 signaling. Methods: In present study, animal models were established with AopE-/- mice, and Raw 264.7 macrophage mimicked high corticosterone treatment, These...
Although a range of studies indicated Liver X receptor (LXR) activation inhibited the development atherosclerosis in animal models, mechanism this effect for LXR agonists has not been fully understood. A recent study suggested activators increased amount free cholesterol plasma membrane human macrophages by inducing Niemann-Pick type C1 (NPC1) gene expression. Therefore, we hypothesize that LXRs may also promote NPC1 expression vivo. Here investigated synthetic agonist T0901317 on...
Abstract Introduction Our previous study has confirmed that a novel curcumin derivate nicotinate‐curcumin (NC) can facilitate autophagic flux in THP‐1 cells induced by oxidized low‐density lipoprotein. Aims Given autophagy plays critical roles neurodegenerative diseases, the present was carried out to investigate whether NC improve cognitive function of rats with diabetes mellitus (DM) via restoring CA1 hippocampus. Results results showed treatment improved deficit and attenuated neuronal...
Results of previous studies have suggested that cardiovascular autonomic neuropathy (CAN) may predict rapid kidney function decline among people with diabetes. We analyzed the association between baseline CAN and subsequent glomerular filtration rate (GFR) individuals type 1 diabetes (T1D) from Preventing Early Renal Loss in Diabetes (PERL) study (N = 469) 2 (T2D) Action to Control Cardiovascular Risk (ACCORD) 7,973). Baseline was ascertained electrocardiogram-derived heart variability...
Abstract Aims Our previous study indicated that chronic stress caused autophagy impairment and subsequent neuron apoptosis in hippocampus. However, the mechanism underlying stress‐induced damage to neurons is unclear. In present work, we investigated whether stress‐level glucocorticoids (GCs) GCs promoted PC12 cell via AMPK/mTOR signaling‐mediated autophagy. Methods Chronic injury model was built by treatment with high level corticosterone (CORT). Cell evaluated flow cytometry assay...
Advanced oxidation protein products (AOPPs) are new independent risk factor for coronary artery disease. This study was to determine the effects and potential mechanisms of AOPPs on cholesterol efflux from human macrophage foam cells.Human THP-1 monocytes were preincubated with Phorbol-12-myristate- 13-acetate (PMA) oxidized low density lipoprotein (ox-LDL) form cells. The mRNA expression examined by western immunoblotting assays real-time quantitative PCR, respectively. Cellular content...
Adenosine triphosphate-binding cassette transporter A1 (ABCA1) plays a crucial role in apolipoprotein A-I (apoA-I) binding activity and promotes cellular cholesterol efflux. ApoA-I mimetic peptide D4-F has reported to have the similar ability as apoA-I. However, detailed mechanisms of ABCA1 regulation by are not understood. In present study, we investigated effects on expression ABCA1-dependent efflux examined Cdc42/cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) pathway THP-1...
Self-management of blood glucose levels to avoid hypoglycemia is vital for patients with type 2 diabetes mellitus (T2DM). The association between specific metrics glycemic variability (glycosylated hemoglobin A1c [HbA1c] and fasting plasma [FPG]) severe has not been fully studied in T2DM.
Atherosclerosis, a major contributor to cardiovascular disease, remains significant health concern worldwide. While previous research has shown that acid-sensing ion channel 1 (ASIC1) impedes macrophage cholesterol efflux, its precise role in atherogenesis and the underlying mechanisms have remained elusive.
Background Study of the relationship between mast cells and atherosclerosis is mostly dependent on pathological observation cytology experiments. To investigate effects degranulation plaque their possible mechanisms we used apolipoprotein E knockout mice which had been placed perivascular common carotid collar with degranulator compound 48–80. Methods Forty were fed a western-type diet operated placement right collar. Four weeks after surgery, intraperitoneally injected 48–80 (0.5 mg/kg) or...
Coronary heart disease (CHD) is closely related to hypercholesterolemia, and lowering serum cholesterol currently the most important strategy in reducing CHD. In humans, level determined mainly by three metabolic pathways, namely, dietary intake, synthesis, degradation vivo. An intervention that targets key molecules pathways an lipids. Statins inhibit 3-hydroxyl-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) reduce low-density lipoprotein (LDL) about 20% 45%. However, up 15% of...