A5038948748- Diabetic Foot Ulcer Assessment and Management
- Peripheral Artery Disease Management
- Chronic Kidney Disease and Diabetes
- Wound Healing and Treatments
- Diabetes Treatment and Management
- Diagnosis and Treatment of Venous Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- Diet and metabolism studies
- Cerebrovascular and Carotid Artery Diseases
- Pressure Ulcer Prevention and Management
- Orthopedic Infections and Treatments
- Liver Disease Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Diabetes Management and Research
- Electrolyte and hormonal disorders
- Renal and Vascular Pathologies
- Botulinum Toxin and Related Neurological Disorders
- Vascular Procedures and Complications
- Acute Ischemic Stroke Management
- Cardiovascular Function and Risk Factors
- Skin Diseases and Diabetes
- Neurological and metabolic disorders
- Orthopedic Surgery and Rehabilitation
- Reconstructive Surgery and Microvascular Techniques
Policlinico Abano Terme
2006-2022
Presidio Ospedaliero
2013
National Research Council
2002
University of Padua
1991-2002
University of Sassari
2000
Policlinico Universitario di Catania
1992
Upon activation, neutrophils undergo histone citrullination by protein arginine deiminase (PAD)4, exocytosis of chromatin and enzymes as neutrophil extracellular traps (NETs), death. In diabetes, are primed to release NETs die NETosis. Although this process is a defense against infection, NETosis can damage tissue. Therefore, we examined the effect on healing diabetic foot ulcers (DFUs). Using proteomics, found that NET components were enriched in nonhealing human DFUs. an independent...
Heterogeneity in renal structure has been described type 2 diabetic patients with both microalbuminuria and proteinuria; fact, only a subset of have the typical glomerulopathy. However, it is currently unknown whether abnormalities albumin excretion rate (AER) different prognostic value depending on underlying structure. Aims this study were: 1) to course function altered AER; 2) evaluate relationship between glomerular filtration (GFR) structure; 3) GFR baseline AER levels, metabolic...
Contrasting information has been reported concerning the course of renal function in NIDDM with hypertension alone or association damage. The aim present study was to elucidate glomerular filtration rate (GFR) hypertensive patients during antihypertensive therapy. Furthermore, we compared effects ACE inhibitors (cilazapril, Inibace, Roche, Milan, Italy) and Ca2+-channel blockers (amlodipine, Norvasc, Pfizer, Rome, Italy). Of attending outpatient's clinic internal medicine departments...
Charcot neuroarthropathy is a serious complication associated with diabetic neuropathy. This probably most when the ankle involved because of instability and progressive deformity, which often leads to ulceration, osteomyelitis, amputation. Arthrodesis before ulcerated lesion appears considered limb salvage treatment. One effective techniques for an unstable in retrograde transcalcaneal nailing.Eighteen patients, without history were treated from July, 2003, November, 2005, panarthrodesis...
Diabetic foot (DF) is a chronic and highly disabling complication of diabetes. The prevalence peripheral arterial disease (PAD) high in diabetic patients and, associated or not with neuropathy (PN), can be found 50% cases DF. It worth pointing out that the number major amputations still very high. Many PAD are revascularised due to lack technical expertise or, even worse, negative beliefs because poor experience. This despite progress obtained techniques distal revascularisation nowadays...
The minimal model is widely used to evaluate insulin action on glucose disappearance from frequently sampled intravenous tolerance tests (FSIGT). common protocols are a regular (rFSIGT, single injection of 0.3 g/kg glucose) and an insulin-modified test (mFSIGT, with additional administration at 20 min). This study compared the sensitivity index (S I ) effectiveness G obtained in same individual (16 normal subjects) two tests. S was 7.11 ± 0.80 10 −4 ⋅ min −1 μU ml rFSIGT 6.96 0.83 mFSIGT ( P...
Background Stent‐based revascularization of long femoro‐popliteal (FP) lesions has been mainly studied in claudicants and compromised by restenosis stent fractures. The Supera ® stent's biomimetic design allows enhanced fracture resistance. Data for stenting to treat chronic total occlusions (CTOs) patients with critical limb ischemia (CLI), are scarce. Objective To assess long‐term outcomes subintimal stenting, FP CTOs CLI. Methods Prospective, single‐center, single‐arm study 34 consecutive...
To appraise clinical results of foot arteries recanalization using percutaneous retrograde transmetatarsal access followed by and tibial vessels.Arterial revascularization means transluminal angioplasty (PTA) is a mainstay in the management patients with critical limb ischemia (CLI). Nonetheless, when employing standard approaches, success rate remain suboptimal. We report through artery access.From September 2011 to November 2012, 38 (28 men; mean age 73.2 ± 11.4 years) underwent after...
Type 2 diabetic patients often die because of end-stage renal failure, but no definitive reliable factor predicting long-term outcome has been identified. We tested whether a arterial resistance index (R/I) > or =80, using Doppler ultrasound technique, was predictive worsening function. The primary end points the study were 1) course glomerular filtration rate (GFR) and 2) albumin excretion in 157 microalbuminuric, hypertensive, type after 7.8-year follow-up period (range 7.1-9.2)....
The study aims to evaluate the effectiveness of foot revascularization in persons with diabetic ulcers (DFUs) and below-the-ankle (BTA) arterial disease. Consecutive patients referred for a new active ischaemic DFU requiring lower limb were considered. Among those, only BTA disease included. Revascularization procedures retrospectively analysed: case successful (recanalization pedal artery, or plantar arteries both) not, respectively divided two groups, perfusion (SFP) failed (FFP). Healing,...
It has not yet been fully clarified whether the plasma or renal clearance approach is most reliable to investigate GFR in humans. The study presented here aimed compare decay with of 51Cr-EDTA 27 diabetic patients patterns function broadly dispersed a wide range values. Moreover, comparison was also performed nonlabeled iothalamate subgroup 17 patients. A biexponential found fulfill statistical and heuristic criteria for modeling analysis 19 samples after bolus intravenous injection....
Insulin resistance may be a mechanism linking non-insulin-dependent diabetes mellitus (NIDDM) to hypertension and cardiovascular mortality. Microalbuminuria also is an independent risk factor of mortality hypertension. Little information available in the literature on relationship between microalbuminuria insulin action. This study investigated relationships blood pressure (BP) levels, microalbuminuria, NIDDM patients. Seventy-five patients attending outpatient clinic Department Internal...
Aim . To evaluate the prognostic role of procalcitonin (PCT) in patients with diabetic foot infection (DFI) and critical limb ischemia (CLI). Materials Methods The study group was composed DFI CLI. All were treated according to a preset salvage protocol which includes revascularization, wound debridement, antibiotic therapy, offloading. Inflammatory markers, including PCT, evaluated at admission. Only positive values greater than 0.5 ng/ml, considered. Hospital outcomes categorized as...
The study aimed to evaluate clinical and vascular characteristics, as well outcomes, for diabetic persons with foot ulceration no-option critical limb ischemia (CLI). group included a sample of patients admitted our unit because new ulcer CLI. All subjects were managed using salvage protocol which includes lower-limb revascularization. According whether or not the revascularization procedure was success, respectively divided into two groups: successfully treated CLI (ST-CLI) (NO-CLI). Failed...
The aim of this study was to investigate the relationships among insulin resistance and albumin excretion rate in 25 nondiabetic patients with essential hypertension 28 non-insulin dependent diabetes mellitus (NIDDM). Two groups healthy subjects matched for age, sex, weight served as controls. Patients were divided into two subgroups: without (H1) (H2) microalbuminuria. Diabetic four those normoalbuminuria (NIDDM1) (NIDDM2) microalbuminuria (NIDDM3) (NIDDM4) hypertension. Whole-body glucose...