Abdominal obesity and hyperinsulinemia play a key role in the development of polycystic ovary syndrome (PCOS). Dietary-induced weight loss administration insulin-lowering drugs, such as metformin, are usually followed by improved hyperandrogenism related clinical abnormalities. This study was carried out to evaluate effects combined hypocaloric diet metformin on body weight, fat distribution, glucose-insulin system, hormones group 20 obese PCOS women[ mass index (BMI) > 28 kg/m2] with...

The pattern of episodic gonadotropin release was studied in 15 normal female volunteers during the luteal phase menstrual cycle with 24 h blood sampling for follicle-stimulating hormone (FSH) and luteinizing (LH) levels at 10-min intervals. Six subjects (two early, two mid-, late phase) also had each these specimens processed progesterone levels. A progressive slowing LH pulsations present across mean pulse frequency declining from 15.2 pulses/24 early to 8.4/24 phase. trend towards...

To characterize the spectrum of pulsatile gonadotropin secretion during course normal menstrual cycle, we studied women 51 ovulatory cycles. Plasma concentrations were measured at 10-min intervals for 20–24 h early, mid-, and late follicular phases luteal phases. LH data series analyzed using 2 different computer-assisted algorithms pulse detection. The interpulse interval decreased phase (FP) from 94 ± 4 (±SEM) min in early FP (EFP) to 71 by (LFP; P < 0.001). estimation frequency EFP was...

To examine gonadotropin secretory frequency as a component of the disordered neuroendocrine regulation secretion in women with polycystic ovarian disease (PCOD), we measured serum concentrations 12 PCOD at 10-min intervals for periods 12-24 h. The patterns LH and FSH release these patients were compared to findings 24 studies 21 age-matched normal during early, mid- late follicular phases (EFP, MFP LFP) their cycles. Serum sex steroid levels h study those studied phase. mean estradiol (E2)...

The aim of the study described here was to evaluate any possible effect L-carnitine on spermatozoal motility in a group patients with unexplained asthenozoospermia four different infertility centres. One hundred received 3 g d-1 oral for 4 months. Sperm parameters were studied before, during and after this treatment. Motility also by means computer-assisted sperm analysis. results indicate that is able increase motility, both quantitative qualitative manner (per cent motile spermatozoa...

Intensive FSH stimulation is a key tool of assisted reproduction technology but can cause severe complications through the development an excessive number small ovarian follicles. We tested hypothesis that, in late stages ovulation induction, LH activity form low-dose human CG (hCG) stimulate and selectively modulate follicle function growth, independently administration. Four groups GnRH agonist-suppressed normoovulatory women (10 each group) received recombinant (r-hFSH) (150 IU/d) for 7 d...

Although FSH is essential to stimulate ovarian folliculogenesis, increasing physiological and clinical evidence suggests that moderate LH stimulation may also be critical for optimal follicle oocyte development. Conversely, a trend exists toward conducting controlled hyperstimulation (COH) in LH-depleted environment, as recently developed gonadotropin preparations are devoid of activity, endogenous suppressed with GnRH analogs most COH cycles. To investigate the role activity during we...

Although the role that LH plays in folliculogenesis is still controversial, recent evidence points toward facilitatory actions of activity ovulation induction. Thus, we compared response to either highly purified FSH (75 IU FSH/ampoule; group A, 25 subjects) or human menopausal gonadotropin and 75 LH/ampoule; B, normoovulatory GnRH agonist-suppressed women, candidates for intrauterine insemination. A fixed regimen 2 daily ampoules was administered initial 14 days treatment; menotropin dose...

Journal Article Treatment of anovulation with pulsatile gonadotropin-releasing hormone: prognostic factors and clinical results in 600 cycles Get access M Filicori, Filicori 1Reproductive Endocrinology Center, University Bologna, Italy. Search for other works by this author on: Oxford Academic Google Scholar C Flamigni, Flamigni P Dellai, Dellai G Cognigni, Cognigni L Michelacci, Michelacci R Arnone, Arnone Sambataro, Sambataro A Falbo The Clinical & Metabolism, Volume 79, Issue 4, 1 October...

BACKGROUND: To test the effects of progressively decreasing dosages exogenous LH we combined various amounts HMG, containing FSH, and HCG, highly purified (HP) FSH to treat 120 GnRH agonist-suppressed infertile female patients as candidates for controlled ovarian stimulation (COS). METHODS: Subjects were randomly assigned four treatment groups that received following daily i.m. gonadotrophin regimens: A, 150 IU only; B, activity 37.5 IU; C, 75 D, IU. dose adjustments allowed only after 14th...

Eighteen women with well characterized hypothalamic amenorrhea underwent 30cycles of pulsatile GnRH treatment in an effort to examine the role dosage pituitary and ovarian responses. was administered iv at 2 doses (25 100 ng/kg bolus) a physiological range frequencies (90 60 min) follicular phase induced cycles. After demonstration ovulation by ultrasound clinical parameters, frequency administrationwas progressively slowed from every min 90 then 240 mimic theslowing endogenous LH secretion...

A number of factors influence the success oocyte cryopreservation and subsequent ICSI. The aim present study is to establish ideal time, after retrieval, for human via slow freezing/rapid thawing protocol with 0.3 M sucrose concentration in cryoprotectant solution (SF/RT M).Retrospective 75 patients on clinical outcome 93 cycles divided into three groups. Group A: freezing within 2 h from retrieval. B: between 3 C: h.The rate best quality embryos was significantly higher (35.2%; P = 0.050)...