A5003061908- Angiogenesis and VEGF in Cancer
- Coronary Interventions and Diagnostics
- Mesenchymal stem cell research
- Peripheral Artery Disease Management
- Lipoproteins and Cardiovascular Health
- S100 Proteins and Annexins
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nuclear Receptors and Signaling
- Biomarkers in Disease Mechanisms
- Frailty in Older Adults
- Cardiac, Anesthesia and Surgical Outcomes
- Renal and related cancers
- Intensive Care Unit Cognitive Disorders
- Cardiovascular Health and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Vitamin K Research Studies
- Sepsis Diagnosis and Treatment
- Telomeres, Telomerase, and Senescence
- MicroRNA in disease regulation
- Alzheimer's disease research and treatments
- Health, Environment, Cognitive Aging
- Tissue Engineering and Regenerative Medicine
- Cancer, Lipids, and Metabolism
MultiMedica
2019-2022
University of Milan
2021
Mario Negri Institute for Pharmacological Research
2018
Mesenchymal stromal cell (MSC)-based therapy is a promising strategy for preventing the progression of chronic kidney disease (CKD), with potential to induce tissue regeneration. In search best cellular source we compared, in rat model adriamycin (ADR) nephropathy, regenerative human cells non-renal origin, such as bone marrow (bm) MSCs and umbilical cord (uc) MSCs, that newly discovered renal perivascular (kPSCs) known exhibit tissue-specific properties. The therapeutic effect repeated...
OBJECTIVE In patients with type 2 diabetes (T2D) and critical limb ischemia (CLI), migration of circulating CD34+ cells predicted cardiovascular mortality at 18 months after revascularization. This study aimed to provide long-term validation mechanistic understanding the biomarker. RESEARCH DESIGN AND METHODS The association between cell was reassessed 6 years a new series T2D-CLI control subjects, immuno-sorted bone marrow were profiled for miRNA expression assessed apoptosis angiogenesis...
Abstract Frailty affects the physical, cognitive, and social domains exposing older adults to an increased risk of cardiovascular disease death. The mechanisms linking frailty outcomes are mostly unknown. Here, we studied association abundance (flow cytometry) gene expression profile (RNAseq) stem/progenitor cells (HSPCs) molecular markers inflammaging (ELISA) with cardiorespiratory phenotype prospective adverse events individuals classified according levels frailty. Two cohorts were...
<b>Objective</b>. In patients with type 2 diabetes (T2D) and critical limb ischemia (CLI), migration of circulating CD34<sup>+</sup> cells predicted cardiovascular mortality at 18 months post-revascularization. This study aimed to provide long-term validation mechanistic understanding the biomarker. <p><b>Research Design Methods</b>. The association between cell was reassessed 6 years a new series T2D-CLI control subjects, immuno-sorted bone marrow...
<b>Objective</b>. In patients with type 2 diabetes (T2D) and critical limb ischemia (CLI), migration of circulating CD34<sup>+</sup> cells predicted cardiovascular mortality at 18 months post-revascularization. This study aimed to provide long-term validation mechanistic understanding the biomarker. <p><b>Research Design Methods</b>. The association between cell was reassessed 6 years a new series T2D-CLI control subjects, immuno-sorted bone marrow...
Abstract Background/Introduction The annual rate of restenosis, amputation, and death subjects with type 2 diabetes (T2DM) critical limb ischemia (CLI) is very high even after successful revascularization. We have recently demonstrated that the in-vitro migratory ability proangiogenic bone marrow (BM)-derived CD45dimKDR+CXCR4+ CD34+ cells predicts cardiovascular mortality at 18 months percutaneous angioplasty (PTA) in people T2DM CLI. Purpose To verify predictor a longer follow-up time to...
Importance: Frailty affects the physical, cognitive, and social domains exposing older adults to an increased risk of cardiovascular diseases death. The mechanisms linking frailty outcomes are mostly unknown. Objective: Here, we studied association hematopoietic stem/progenitor cells (HSPCs) molecular markers inflammaging with cardiopulmonary phenotype prospective adverse events individuals classified according levels frailty. Methods: We conducted one observational study on two patients’...