A5067528375- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Cardiovascular and Diving-Related Complications
- Parkinson's Disease Mechanisms and Treatments
- SARS-CoV-2 detection and testing
- Amyotrophic Lateral Sclerosis Research
- High Altitude and Hypoxia
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Multiple Sclerosis Research Studies
- Blood properties and coagulation
- Nerve injury and regeneration
- Sepsis Diagnosis and Treatment
- Diabetes Management and Research
- Neurogenetic and Muscular Disorders Research
- Erythrocyte Function and Pathophysiology
- Animal Virus Infections Studies
- Clinical Laboratory Practices and Quality Control
- Vitamin D Research Studies
- Diabetes and associated disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Ion channel regulation and function
- RNA Research and Splicing
- Neurogenesis and neuroplasticity mechanisms
- Spaceflight effects on biology
University of Rome Tor Vergata
2016-2025
University of Salento
2024
Policlinico Tor Vergata
2021-2022
University of Naples Federico II
2021
University of Bologna
2016
Policlinico S.Orsola-Malpighi
2016
Fondazione Santa Lucia
2004-2012
Istituto Superiore di Sanità
2002-2003
Amyotrophic lateral sclerosis (ALS) is a lethal disorder characterized by the gradual degeneration of motor neurons in cerebrospinal axis. Whether upper neuron hyperexcitability, which feature ALS, provokes dysfunction glutamate metabolism and lower via an anterograde process undetermined. To examine whether early changes activity occur association with glutamatergic alterations, we performed whole-cell patch-clamp recordings to analyze excitatory properties Layer V cortical postsynaptic...
The outbreak of 2019 novel coronavirus disease (Covid-19) caused by SARS-CoV-2 has spread rapidly, inducing a progressive growth in infected patients number. Social isolation (lockdown) been assessed to prevent and control virus diffusion, leading worldwide financial political crisis. Currently, RNA detection nasopharyngeal swab takes place real-time PCR (RT-qPCR). However, molecular tests can give some false-negative results. In this context, serological assays be useful detect IgG/IgM...
Flavonoids display a broad range of structures and are responsible for the major organoleptic characteristics plant-derived foods beverages. Recent data showed their activity, in particular luteolin-7-O-glucoside (LUT-7G), reduction oxidative stress inflammatory mechanisms different physiological systems. In this paper, we tried to elucidate how LUT-7G could exert both antioxidant anti-inflammatory effects endothelial cells cultured vitro. Here, that is able inhibit STAT3 pathway, have an...
Diagnostics is crucial for a prompt identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients, their isolation and treatment. Real-time PCR the reference method diagnosis SARS-CoV-2 infection; however, unprecedented increase in number infections worldwide calls faster easy methods that do not require skilled personnel special equipment. Rapid antigen tests have been developed used as first line screening. Here, we assessed performance rapid test...
Objective Preliminary findings suggest a relationship between lower serum 25-hydroxyvitamin D [25(OH)D] levels and incidence severity of COVID-19. The aim this study was to evaluate the vitamin status at admission different markers inflammation, coagulation, sepsis in hospitalized patients with
Abstract Background and purpose Parkinson disease (PD) presents relevant sex‐related differences in epidemiology, pathophysiology, clinical features, with males being more vulnerable to the disease. Sex hormones might have a role, as experimental models suggest; however, human‐based evidence is scarce. Here, we integrated multimodal biomarkers investigate relationships between circulating sex clinical–pathological features male PD patients. Methods A cohort of 63 patients underwent...
The mechanism whereby the morphology and connectivity of dendritic tree is regulated depends on an actin dynamics that, in turn, controlled by Rho GTPases, a family small GTP-binding proteins encompassing Rho, Rac, Cdc42 subfamilies. Cytotoxic necrotizing factor 1 (CNF1), protein toxin from Escherichia coli , constitutively activates thus leading to remodeling cytoskeleton intact cells. Here, we show that modulation cerebral RhoA Rac1 activity induced CNF1 mice leads ( i ) rearrangement...
Decompression sickness (DCS) is a systemic disorder, assumed due to gas bubbles, but additional factors are likely play role. Circulating microparticles (MPs)—vesicular structures with diameters of 0.1-1.0 μm—have been implicated, data in human divers have lacking. We hypothesized that the number blood-borne, Annexin V-positive MPs and neutrophil activation, assessed as surface MPO staining, would differ between self-contained underwater breathing-apparatus suffering from DCS vs....
Several commercial surrogate Virus Neutralization Tests (sVNTs) have been developed in the last year. Neutralizing anti-SARS-CoV-2 antibodies through interaction with Spike protein Receptor Binding Domain (S-RBD) can block virus from entering and infecting host cells. However, there is a lack of information about functional activity SARS-CoV-2 that may be associated protective responses. For these reasons, to counteract viral infection, conventional neutralization test (VNT) still considered...
The World Health Organization has recently identified three categories of pathogens, namely: critical, high, and medium priority, according to the need for new antibiotics. Critical priority pathogens include carbapenem-resistant microorganism (CPO) such as A. baumannii P. aeruginosa, K. pneumoniae, Enterobacter spp., whereas vancomycin-resistant E. faecium (VRE), methicillin S. aureus (MRSA) are in high list. We compared trend antimicrobial resistants (AMRs) clinical isolates, divided by...
The present study explores the hypothesis that antiepileptic mechanism of action levetiracetam (LEV) is related to effects on alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor channels in mouse cortical neurons culture.The were subjected whole-cell configuration patch-clamp recording technique and 8-12 days old culture.Kainate elicited concentration-dependent (EC(50)= 80 microM) inward currents all patched cells. LEV (5-200 itself did not induce or outward neurons,...
Introduction: The popularity of SCUBA diving is steadily increasing together with the number dives and correlated diseases per year. rules that govern correct decompression procedures are considered well known even if majority Decompression Sickness (DCS) cases unexpected confirming a bias in "mathematical ability" to predict DCS by current algorithms. Furthermore, little still about risk factors any individual predisposition DCS. This study provides an in-depth epidemiological analysis...
Abstract Rapid and accurate measurement of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)-specific neutralizing antibodies (nAbs) is paramount for monitoring immunity in infected vaccinated subjects. The current gold standard relies on pseudovirus neutralization tests which require sophisticated skills facilities. Alternatively, recent competitive immunoassays measuring anti-SARS-CoV-2 nAbs are proposed as a quick commercially available surrogate virus test (sVNT). Here, we...
Emerging evidence indicates that apolipoprotein E (APOE) genotype may influence Parkinson's disease (PD) course, although clinical and neurochemical correlates have not been completely established. This study aimed to determine the associations of APOE genotypes (ε4 vs. non-ε4) with cerebrospinal fluid (CSF) neurodegeneration biomarkers parameters in early-stage PD patients. One hundred seventy-five patients 89 non-neurodegenerative controls grouped APOE-ε4 carriers (28 PD; 12 controls)...
Background: Metabolic syndrome (MetS) patients have impaired hypothalamic regulatory functions involved in food intake and energy expenditure suffer from a state of meta-inflammation. Pre-clinical studies demonstrated that ultramicronized palmitoylethanolamide (PEA) acts both on the adipose tissue central nervous system, while hydroxytyrosol (HTyr) counteracts several types dysmetabolism. Objectives: The aim our randomized crossover double-blind placebo-controlled pilot study was to evaluate...