A5015660956- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Cerebral Palsy and Movement Disorders
- Glaucoma and retinal disorders
- Ultrasound and Hyperthermia Applications
- Radiomics and Machine Learning in Medical Imaging
- Bone and Joint Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- HIV Research and Treatment
- Fetal and Pediatric Neurological Disorders
- Mitochondrial Function and Pathology
- Family and Disability Support Research
- Cerebrovascular and Carotid Artery Diseases
- Autoimmune Neurological Disorders and Treatments
- Genetics and Neurodevelopmental Disorders
- Muscle activation and electromyography studies
- Radiopharmaceutical Chemistry and Applications
- Advanced X-ray and CT Imaging
- Liver Disease Diagnosis and Treatment
- Genetic Neurodegenerative Diseases
- Balance, Gait, and Falls Prevention
- Retinal Imaging and Analysis
- Atomic and Subatomic Physics Research
University of Rome Tor Vergata
2018-2025
Policlinico Tor Vergata
2019-2025
Bambino Gesù Children's Hospital
2018-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2020
Expert System (Italy)
2015-2019
Sapienza University of Rome
2016
Abstract Background and purpose Parkinson disease (PD) presents relevant sex‐related differences in epidemiology, pathophysiology, clinical features, with males being more vulnerable to the disease. Sex hormones might have a role, as experimental models suggest; however, human‐based evidence is scarce. Here, we integrated multimodal biomarkers investigate relationships between circulating sex clinical–pathological features male PD patients. Methods A cohort of 63 patients underwent...
Background: Intra-arterial cerebral infusion (IACI) of radiotherapeutics is a promising treatment for glioblastoma (GBM) recurrence. We investigated the in silico feasibility and safety Yttrium-90-Poly(vinyl alcohol)-Microbubble (90Y-PVA-MB) IACI patients with recurrent GBM compared results those external beam radiation therapy (EBRT). Methods: Contrast-enhanced T1-weighted magnetic resonance imaging (T1W-MRI) was used to delineate tumor volumes CT scans were automatically segment organs at...
Background/Objectives: Parkinson's disease (PD) is characterized by progressive neurodegeneration affecting both motor and non-motor functions. Identifying early alterations in PD patients before the onset of dopaminergic therapy crucial for understanding progression developing targeted interventions. This study aimed to investigate changes putamen thalamus de novo using diffusion tensor imaging (DTI) compared healthy controls. Methods: Thirty-one thirty-three controls underwent DTI...
Primary open angle Glaucoma (POAG) is one of the most common causes permanent blindness in world. Recent studies have suggested hypothesis that POAG also a central nervous system disorder which may result additional (i.e., extra-ocular) involvement. The aim this study to assess possible structural, whole-brain connectivity alterations patients. We evaluated 23 patients and 15 healthy controls by combining multi-shell diffusion weighted imaging, multi-shell, multi-tissue probabilistic...
Background: Resting-state functional magnetic resonance imaging (rs-fMRI) is commonly employed to study changes in brain connectivity. The recent hypothesis of a involvement primary open angle Glaucoma has sprung interest for neuroimaging studies this classically ophthalmological pathology. Object: We explored putative reorganization networks Glaucomatous patients, and evaluated the potential network disruption indices as biomarkers disease severity terms their relationship clinical...
Background Reduced field of view (rFOV) imaging may be used to improve the quality diffusion-weighted (DWI) in head and neck (HN) region. Purpose To evaluate feasibility rFOV-DWI patients affected by HN tumors, through a comparison with conventional full FOV (fFOV) DWI. Material Methods Twenty-two histologically-proven malignant or benign tumors were included retrospective study. All underwent pre-treatment magnetic resonance (MRI) studies including fFOV-DWI. The apparent diffusion...
Glaucoma is an optic neuropathy characterized by death of retinal ganglion cells and loss their axons, progressively leading to blindness. Recently, glaucoma has been conceptualized as a more diffuse neurodegenerative disorder involving the nerve also entire brain. Consistently, previous studies have used variety magnetic resonance imaging (MRI) techniques described widespread changes in grey white matter patients. Diffusion kurtosis (DKI) provides additional information compared with...
The recessive ataxia ARCA2 is a rare disorder characterized by Coenzyme Q10 (CoQ10) deficiency due to biallelic mutations in ADCK3 gene. Despite the pathophysiological role, available data are not univocal on clinical efficacy of CoQ10 supplementation ARCA2. Here we described long-term motor outcome 4 untreated patients prospectively followed-up for one year after starting oral (15 mg/kg/day).Clinical rating scales (SARA; 9 holes peg test; 6 min walking Timed 25-Foot Walk) and...
This proof-of-concept study lays the foundations for development of a delivery strategy radioactive lanthanides, such as Yttrium-90, against recurrent glioblastoma. Our appealing hypothesis is that by taking advantage combination biocompatible polyvinyl alcohol (PVA) microbubbles (MBs) and endovascular radiopharmaceutical infusion, minimally invasive selective radioembolization can be achieved, which lead to personalized treatments limiting off-target toxicities normal brain. The results...
Treatment planning in microwave thermal ablation (MTA) requires the capability to predict and estimate shape dimension of thermally coagulated zone obtainable following a clinical protocol. The ultimate result relies on knowledge performance device, as well temperature-dependent structural modifications that tissue undergoes during treatment, because very high temperatures reached (up 100 °C or higher). In this respect, shrinkage plays an important role, since ablated evaluated at end MTA...
Computed tomography perfusion (CTP) and multiphase CT angiography (mCTA) help selection for endovascular treatment (EVT) in anterior ischemic stroke (AIS). Our aim was to investigate the ability of maps collateral score predict functional outcome after EVT.Patients with M1-middle cerebral artery occlusion, evaluated by mCTA CTP treated EVT within six hours onset, were enrolled. Perfusion parametric blood flow (CBF), volume (CBV) time maximum tissue residue function ( Tmax) generated; areas...
Resting-state functional magnetic resonance imaging (rs-fMRI) is commonly employed to study changes in brain connectivity. Recently, the hypothesis of a involvement primary open angle glaucoma has sprung interest for neuroimaging studies this pathology. The purpose evaluate putative reorganization networks glaucomatous patients through graph-theoretical measures integration, segregation and centrality by exploiting multivariate association measure recently introduced global local network...
Background and Objectives To compare navigator-gated three-dimensional T1-weighted gradient-echo sequences (NG-3D T1W-GRE) with standard breath-hold T1W-GRE (BH for the detection of HCC nodules in patients chronic viral hepatitis which undergo at magnetic resonance imaging (MRI) using gadoxetic acid. Methods materials We evaluated 58 hepatic least 1 cm diameter detected by ultrasound who underwent liver MRI including NG-3D breath hold different flip angles(FA) 10-25-40° after...
Although robotic-assisted locomotor treadmill therapy is utilized on children with cerebral palsy (CP), its impact the gait pattern in childhood not fully described. We investigated outcome of robotized training focusing modifications and mobility individuals CP. An additional intention to compare our results previous literature advancing future solutions. Twenty-four diplegic CP (average age 6.4 years old Gross Motor Functional Classification System range I–IV) received five times per week...
While previous studies have demonstrated the feasibility and potential usefulness of quantitative non-Gaussian diffusional kurtosis imaging (DKI) brain, more recent research has focused on oncological application DKI in various body regions such as prostate, breast, head neck (HN). Given need to minimize scan time during most routine magnetic resonance (MRI) acquisitions regions, diffusion-weighted (DWI) with only three orthogonal diffusion weighting directions (x, y, z) is usually...