A5011561452- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Acute Ischemic Stroke Management
- MRI in cancer diagnosis
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Glaucoma and retinal disorders
- Glioma Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Vascular Malformations Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Hepatocellular Carcinoma Treatment and Prognosis
- Fetal and Pediatric Neurological Disorders
- Liver Disease Diagnosis and Treatment
- Neurological and metabolic disorders
- Ultrasound and Hyperthermia Applications
- HIV Research and Treatment
- Venous Thromboembolism Diagnosis and Management
- Neural dynamics and brain function
- Head and Neck Cancer Studies
- Lymphoma Diagnosis and Treatment
University of Rome Tor Vergata
2016-2025
The University of Melbourne
2021
The Royal Melbourne Hospital
2021
Austin Health
2021
Walter and Eliza Hall Institute of Medical Research
2021
Policlinico Tor Vergata
2013-2020
Università degli studi di Cassino e del Lazio Meridionale
2019
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2019
The National Institutes of Health Stroke Scale (NIHSS) underestimates clinical severity in posterior circulation stroke and patients presenting with low NIHSS may be considered ineligible for reperfusion therapies. This study aimed to develop a modified version the NIHSS, Posterior (POST-NIHSS), improve prognostic accuracy mild-moderate symptoms.Clinical data consecutive symptoms (NIHSS <10), who were conservatively managed, retrospectively analyzed from Basilar Artery Treatment Management...
Abstract Background and purpose Parkinson disease (PD) presents relevant sex‐related differences in epidemiology, pathophysiology, clinical features, with males being more vulnerable to the disease. Sex hormones might have a role, as experimental models suggest; however, human‐based evidence is scarce. Here, we integrated multimodal biomarkers investigate relationships between circulating sex clinical–pathological features male PD patients. Methods A cohort of 63 patients underwent...
To investigate the efficacy of tenecteplase (TNK), a genetically modified variant alteplase with greater fibrin specificity and longer half-life than alteplase, prior to endovascular thrombectomy (EVT) in patients basilar artery occlusion (BAO).To determine whether TNK is associated better reperfusion rates EVT BAO, clinical procedural data consecutive BAO from Basilar Artery Treatment Management (BATMAN) registry Tenecteplase vs Alteplase before Endovascular Therapy for Ischemic Stroke...
Posterior reversible encephalopathy syndrome (PRES) is a serious adverse event associated with calcineurin inhibitors used for graft-versus-host disease (GVHD) prophylaxis. We compared the incidence of PRES in children thalassemia (n = 222, 1.4 to 17.8 years old) versus sickle cell (SCD; n 59, 2 17 who underwent hematopoietic transplantation from HLA-matched siblings or alternative donors and analyzed risk factors PRES. Overall, 31 developed inhibitor-related (11%), including 30 patients...
Background and Purpose- The benefit of endovascular therapy in extended time windows has been demonstrated patients with anterior circulation large vessel occlusion ischemic stroke favorable imaging profile. We evaluated whether collaterals thrombus burden influence the associations between revascularization, time-to-treatment, outcome therapy-treated basilar artery occlusion. Methods- retrospectively analyzed clinical data consecutive included multicenter Basilar Artery Treatment Management...
Abstract Background Functional connectivity (FC) has shown promising results in assessing the pathophysiology and identifying early biomarkers of neurodegenerative disorders, such as Parkinson's disease (PD). Objectives In this study, we aimed to assess possible resting‐state FC abnormalities early‐stage PD patients using high‐density electroencephalography (EEG) detect their clinical relationship with motor non‐motor symptoms. Methods We enrolled 26 levodopa naïve a group 20 healthy...
Idiopathic normal pressure hydrocephalus (iNPH) pathogenesis is multifactorial. Systemic inflammation might have a role in gathering clinical-pathological trajectories. We aimed to shape the peripheral immune profile of iNPH and establish correlations with cerebrospinal fluid (CSF) markers, ventricular enlargement, clinical outcomes.
Abstract Autonomic symptoms in Parkinson’s disease result from variable involvement of the central and peripheral systems, but many aspects remain unclear. The analysis functional connectivity has shown promising results assessing pathophysiology disease. This study aims to investigate association between autonomic cortical early patients using high-density EEG. 53 (F/M 18/35) 49 controls 20/29) were included. evaluated Scales for Outcomes disease–Autonomic Dysfunction score. Data recorded...
Background: Intra-arterial cerebral infusion (IACI) of radiotherapeutics is a promising treatment for glioblastoma (GBM) recurrence. We investigated the in silico feasibility and safety Yttrium-90-Poly(vinyl alcohol)-Microbubble (90Y-PVA-MB) IACI patients with recurrent GBM compared results those external beam radiation therapy (EBRT). Methods: Contrast-enhanced T1-weighted magnetic resonance imaging (T1W-MRI) was used to delineate tumor volumes CT scans were automatically segment organs at...
Background/Objectives: Parkinson's disease (PD) is characterized by progressive neurodegeneration affecting both motor and non-motor functions. Identifying early alterations in PD patients before the onset of dopaminergic therapy crucial for understanding progression developing targeted interventions. This study aimed to investigate changes putamen thalamus de novo using diffusion tensor imaging (DTI) compared healthy controls. Methods: Thirty-one thirty-three controls underwent DTI...
Primary open angle Glaucoma (POAG) is one of the most common causes permanent blindness in world. Recent studies have suggested hypothesis that POAG also a central nervous system disorder which may result additional (i.e., extra-ocular) involvement. The aim this study to assess possible structural, whole-brain connectivity alterations patients. We evaluated 23 patients and 15 healthy controls by combining multi-shell diffusion weighted imaging, multi-shell, multi-tissue probabilistic...
Functional magnetic resonance imaging may provide several quantitative indices strictly related to distinctive tissue signatures with radiobiological relevance, such as cellular density and vascular perfusion. The role of Intravoxel Incoherent Motion Diffusion Weighted Imaging (IVIM-DWI) Dynamic Contrast-Enhanced (DCE) MRI in detecting/predicting radiation-induced volumetric changes parotids both during shortly after (chemo)radiotherapy oropharyngeal squamous cell carcinoma (SCC) was...
Background: Resting-state functional magnetic resonance imaging (rs-fMRI) is commonly employed to study changes in brain connectivity. The recent hypothesis of a involvement primary open angle Glaucoma has sprung interest for neuroimaging studies this classically ophthalmological pathology. Object: We explored putative reorganization networks Glaucomatous patients, and evaluated the potential network disruption indices as biomarkers disease severity terms their relationship clinical...
Summary Acute promyelocytic leukaemia (APL) represents a modern success of precision medicine. However, fatalities occurring within the first 30 days induction treatment, in particular intracranial haemorrhage (ICH), remain main causes death. We studied clinico‐biological characteristics 13 patients with APL who experienced ICH. Compared to 85 without this complication, ICH were older and more frequently had high‐risk APL. Moreover, positivity for ‘swirl’ sign at neuroradiological imaging...
CT perfusion may improve diagnostic accuracy in posterior circulation stroke. The Acute Stroke Prognosis Early score (pc-ASPECTS) on Computed Tomography Angiography source images (CTA-SI) predicts functional outcome patients with basilar artery occlusion.We assessed the prognostic value of pc-ASPECTS vertebral and occlusion (VBAO) comparison CTA-SI.Whole-brain from consecutive stroke VBAO at four centers was retrospectively analyzed. - a 10-point assessing hypoattenuation CTA-SI calculated...
Glaucoma is an optic neuropathy characterized by death of retinal ganglion cells and loss their axons, progressively leading to blindness. Recently, glaucoma has been conceptualized as a more diffuse neurodegenerative disorder involving the nerve also entire brain. Consistently, previous studies have used variety magnetic resonance imaging (MRI) techniques described widespread changes in grey white matter patients. Diffusion kurtosis (DKI) provides additional information compared with...