A5000574646- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- T-cell and Retrovirus Studies
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Liver Disease Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- Herpesvirus Infections and Treatments
- Chromosomal and Genetic Variations
- Immune Cell Function and Interaction
- CRISPR and Genetic Engineering
- Immunotherapy and Immune Responses
- HIV/AIDS drug development and treatment
- SARS-CoV-2 detection and testing
- Cytomegalovirus and herpesvirus research
- Long-Term Effects of COVID-19
- PARP inhibition in cancer therapy
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Cell death mechanisms and regulation
- Chemokine receptors and signaling
- Viral Infections and Outbreaks Research
University of Rome Tor Vergata
2016-2025
Policlinico Tor Vergata
2020-2025
University of Hong Kong
2022
Chinese University of Hong Kong
2022
Istituti di Ricovero e Cura a Carattere Scientifico
2018
Istituto Dermopatico dell'Immacolata
2018
University of Arkansas for Medical Sciences
2005
Czech Academy of Sciences, Institute of Experimental Medicine
1997
The outbreak of 2019 novel coronavirus disease (Covid-19) caused by SARS-CoV-2 has spread rapidly, inducing a progressive growth in infected patients number. Social isolation (lockdown) been assessed to prevent and control virus diffusion, leading worldwide financial political crisis. Currently, RNA detection nasopharyngeal swab takes place real-time PCR (RT-qPCR). However, molecular tests can give some false-negative results. In this context, serological assays be useful detect IgG/IgM...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has had a tremendous impact on health services; hundreds of thousands healthcare workers (HCWs) have died from disease 2019 (COVID-19). introduction the BNT162b2 mRNA vaccine in Italy provided recipients with significant protection against COVID-19 within one to two weeks after administration second recommended doses. While induces robust T cell response, protective role factors and pathways other than those related...
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), encoded by the OLR1 gene, is a scavenger receptor that plays fundamental role in pathogenesis of atherosclerosis. LOX-1 activation associated with apoptosis endothelial cells, smooth muscle cells (SMCs), and macrophages. This process an important underlying mechanism contributes to plaque instability subsequent development acute coronary syndromes. Independent association genetic studies have implicated gene variants myocardial...
Abstract Background Coronaviruses (CoV) are a large family of viruses that common in humans and many animal species. Animal coronaviruses rarely infect with the exceptions Middle East respiratory syndrome ( MERS-CoV ), severe acute corona virus (SARS-CoV), now SARS-CoV-2, which is cause ongoing pandemic coronavirus disease 2019 (COVID-19). Several studies suggested genetic variants ACE2 gene may influence host susceptibility or resistance to SARS-CoV-2 infection according functional role...
Abstract Human microvesicles are key mediators of cell–cell communication. Exosomes function as microRNA transporters, playing a crucial role in physiological and pathological processes. Plant (MVs) display similar features to mammalian exosomes, these MVs might enhance plant delivery mammals. Considering that microRNAs have been newly identified bioactive constituents medicinal plants, their potential regulators mammals has underlined, this study, we characterized purified from Moringa...
To assess the magnitude of COVID-19 spread and associated risk factors among health care workers (HCWs), we conducted an in-hospital survey in a central Italian COVID Hospital. Participants underwent nasopharyngeal swab and/or serum collection for SARS-CoV-2 IgG examination. We divided participants according to working status, into rotating-night shift (r-NSW) day-workers. found 30 cases infection total 1180 HCWs (2.5%). Most COVID-19-positive hospital employees were r-NSWs with...
Abstract SARS-CoV-2 is responsible for the ongoing world-wide pandemic which has already taken more than two million lives. Effective treatments are urgently needed. The enzymatic activity of HECT-E3 ligase family members been implicated in cell egression phase deadly RNA viruses such as Ebola through direct interaction its VP40 Protein. Here we report that NEDD4 and WWP1 interact with ubiquitylate Spike protein. Furthermore, find HECT overexpressed primary samples derived from COVID-19...
Vaccination campaign to contrast the spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has raised issue vaccine immunogenicity in special populations such as people with multiple sclerosis (PwMS) on highly effective disease modifying treatments (DMTs). While humoral responses SARS-CoV-2 mRNA vaccines have been well characterized general population and PwMS, very little is known about cell-mediated conferring protection from infection coronavirus disease-2019...
The Autism Spectrum Disorder (ASD) is a heterogeneous group of neurodevelopmental disorders, clinically diagnosed since the lack reliable biomarkers. aetiology probably attributable to combination genetic vulnerability and environmental factors, recently, maternal immune activation has been linked derailed neurodevelopment, resulting in ASD offspring. Human endogenous retroviruses (HERVs) are relics ancestral infections, integrated human DNA. Given HERV persistence genome, some HERVs have...
Our research group and others demonstrated the implication of human endogenous retroviruses (HERVs) in SARS-CoV-2 infection their association with disease progression, suggesting HERVs as contributing factors COVID-19 immunopathology. To identify early predictive biomarkers severity, we analyzed expression inflammatory mediators SARS-CoV-2-positive -negative nasopharyngeal/oropharyngeal swabs respect to biochemical parameters clinical outcome.Residuals swab samples (20 SARS-CoV-2-negative 43...
In this study we examined the effect of synthetic peptide thymosin-alpha1 (T(alpha)1) on MHC class I expression in FRTL-5 cells. Treatment with T(alpha)1 increased surface molecules and mRNA, which reached its peak (153 +/- 8 % control value) after 12 h. Chloramphenicol acetyltransferase (CAT) analysis, following transfection a plasmid containing regulatory sequence (or deletion derivatives) CAT reporter gene, electrophoretic mobility shift assay experiments demonstrated that action was at...
Etanercept (ETN) is an anti-tumour necrosis factor (TNF)-α agent used in rheumatoid arthritis (RA) and psoriatic (PsA). Few studies focused on the effects of anti-TNF-α peripheral blood cells. We aimed to evaluate cells RA PsA patients during ETN treatment explore their relationships with disease activity. (n = 82) 32) who started were included into study evaluated prospectively before beginning therapy after 14, 22, 54 102 weeks. Patients studied terms activity score 28 joints (DAS28),...
Lam. (MO) is one of the most well-known and widely distributed species Moringaceae family in African communities, various preparations
Disease modifying therapies for multiple sclerosis (MS) can impair the specific immune response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Specifically, it is recognized that ocrelizumab reduces or abrogates anti-SARS-CoV-2 antibody production after natural infection vaccination, while very little known about T-cell responses.We developed an interferon (IFN)-γ release assay (IGRA) detect responses SARS-CoV-2 overnight stimulation of whole blood with peptide libraries...
Abstract Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) is the novel coronavirus responsible for worldwide disease (COVID‐19). We previously observed that Angiotensin‐converting enzyme 2 (ACE2) and Dipeptidyl peptidase‐4 (DPP4) are significantly overexpressed in naso‐oropharyngeal swabs (NPS) of COVID‐19 patients, suggesting their putative functional role progression. ACE2 DPP4 overexpression patients may be associated to epigenetic mechanism, such as miRNA differential...
Specific HBsAg mutations are known to hamper recognition by neutralizing antibodies thus challenging HBV-vaccination efficacy. Nevertheless, information on their impact and spreading over time is limited. Here, we characterize the circulation of vaccine-escape from 2005 2019 correlation with virological parameters in a large cohort patients infected HBV genotype-D (N = 947), dominant Europe. Overall, 17.7% harbours ≥1 mutation highest prevalence subgenotype-D3. Notably, complex profiles...
Hydrodynamic cavitation (HC), as an effective, efficient, and scalable extraction technique for natural products, could enable the affordable production of valuable antioxidant extracts from plant resources. For first time, whole pomegranate (Punica granatum L.) fruits, rich in bioactive phytochemicals endowed with anti-cancer properties, were extracted water using HC. Aqueous fractions sequentially collected during process (M1–M5) lyophilized (L), filtered (A), or used such, i.e., crude...