Simona Gabriella Di Santo

ORCID: 0000-0002-3452-0640
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About
Contact & Profiles
Research Areas
  • Dementia and Cognitive Impairment Research
  • Intensive Care Unit Cognitive Disorders
  • Stroke Rehabilitation and Recovery
  • Respiratory viral infections research
  • Anesthesia and Sedative Agents
  • Neonatal Respiratory Health Research
  • Disability Rights and Representation
  • Epilepsy research and treatment
  • LGBTQ Health, Identity, and Policy
  • COVID-19 and Mental Health
  • Anesthesia and Neurotoxicity Research
  • Frailty in Older Adults
  • Healthcare professionals’ stress and burnout
  • Geriatric Care and Nursing Homes
  • Diet and metabolism studies
  • Virtual Reality Applications and Impacts
  • Obesity, Physical Activity, Diet
  • Family and Disability Support Research
  • Nutritional Studies and Diet
  • Metabolism and Genetic Disorders
  • African Sexualities and LGBTQ+ Issues
  • Pharmacological Effects and Toxicity Studies
  • Long-Term Effects of COVID-19
  • Artificial Intelligence in Healthcare and Education
  • Adolescent Sexual and Reproductive Health

Fondazione Santa Lucia
2013-2024

Istituti di Ricovero e Cura a Carattere Scientifico
2013-2024

Institute of Biomedical Technologies
2013-2024

National Research Council
2013-2024

University of Rome Tor Vergata
2016-2021

Ospedale Infermi di Rimini
2019

Italian Society of Physiotherapy
2018

National Academies of Sciences, Engineering, and Medicine
2013-2015

Regional Health
2013

North West Ambulance Service NHS Trust
2012

To evaluate the incidence of cancer in persons with Alzheimer disease (AD) and AD dementia cancer.This was a cohort study Northern Italy on more than 1 million residents. Cancer derived from local health authority (ASL-Mi1) tumor registry registries drug prescriptions, hospitalizations, payment exemptions. Expected cases were calculated by applying age-, sex-, calendar year-specific rates observed whole population to subgroup constituted newly diagnosed cancers during observation period...

10.1212/wnl.0b013e31829c5ec1 article EN Neurology 2013-07-11

To date, delirium prevalence in adult acute hospital populations has been estimated generally from pooled findings of single-center studies and/or among specific patient populations. Furthermore, the number participants these not exceeded a few hundred. overcome limitations, we have determined, multicenter study, over single day large population patients admitted to and rehabilitation wards Italy. This is point study (called "Delirium Day") including 1867 older (aged 65 years or more) across...

10.1186/s12916-016-0649-8 article EN cc-by BMC Medicine 2016-07-18

Background: The lockdown strategies adopted to limit the spread of COVID-19 infection may lead adopt unhealthy lifestyles which impact on mental well-being and future risk dementia. Older adults with mild cognitive impairment (MCI) or subjective decline (SCD) suffer important health consequences from measures quarantine confinement. Aims: study aimed explore effects elderly at increased Methods: 126 community-dwelling seniors MCI SCD were phone-interviewed assessed questions regarding...

10.3389/fpsyt.2020.578628 article EN cc-by Frontiers in Psychiatry 2020-10-14

There is a pressing demand for improving the quality and efficacy of health care social support services needed by world's growing elderly population, especially those affected mild cognitive impairment (MCI) Alzheimer's disease. Exercise has been demonstrated to mitigate oxidative stress (OxS) that recognized as contributing factor in progression multiple neurodegenerative diseases. Meeting innovative addressed specific needs treatment area mitigation rehabilitation, main objective this...

10.3389/fnagi.2018.00282 article EN cc-by Frontiers in Aging Neuroscience 2018-10-01

Respiratory Syncytial Virus (RSV) is one of the main causes respiratory infections during first year life. Very premature infants may contract more severe diseases and 'late preterm infants' also be susceptible to infection. The aim this study evaluate risk factors for hospitalization life in children born at different gestational ages Italy. A cohort 33-34 weeks age (wGA) newborns matched by sex with two 35-37 wGA > 37 were enrolled a three-year period (2009-2012). Hospitalization...

10.1186/s13052-015-0149-z article EN cc-by ˜The œItalian Journal of Pediatrics/Italian journal of pediatrics 2015-05-25

BackgroundThere is little evidence about the prevalence of cognitive disorders and their effect on in-hospital mortality in large multicenter studies. The objectives 2016th edition “Italian Delirium Day,” a study older patients, were to assess (i) point impairment/no dementia, delirium, delirium superimposed dementia (ii) these conditions mortality.

10.1093/gerona/gly154 article EN The Journals of Gerontology Series A 2018-07-04

The aim of the present analysis was to evaluate association Mediterranean diet (MeDi), smoking habits and physical activity with all-cause mortality in an Italian population during a 20-year follow-up study. A total 1693 subjects aged 40-74 who enrolled study 1991-5 were asked about dietary other lifestyle information at baseline. Adherence MeDi evaluated by score (MedDietScore). healthy computed assigning 1 point each for medium or high adherence MedDietScore, non-smoking activity. Cox...

10.1017/s0007114515000318 article EN British Journal Of Nutrition 2015-03-09

Delirium is a common geriatric syndrome. Few studies have been conducted in nursing home (NH) residents. The aim of this project was to perform point prevalence study delirium Italian NHs.Data collected 71 NHs are presented. Inclusion criteria were age ≥65 years and native speaker. Exclusion coma, aphasia, end-of-life status. Sociodemographic medical data recorded. assessed using the Assessment Test for Cognitive Impairment (4-AT). Patients with 4-AT score ≥4 considered delirium. Motor...

10.1159/000490722 article EN Dementia and Geriatric Cognitive Disorders 2018-01-01

Background: Alzheimer’s disease (AD) is the most common form of dementia. It mainly characterized by a progressive deterioration cognition, but sleep-wake cycle disturbances frequently occur. Irregular cycle, insomnia, and daytime napping usually occur in patients with AD course disease. Objective: The aim present study was to verify mild moderate compared controls, evaluate relationship between impairment neuropsychological testing, CSF biomarkers, orexin concentrations. Methods: Mild were...

10.3233/jad-191124 article EN Journal of Alzheimer s Disease 2020-02-10
Alessandro Morandi Simona Gabriella Di Santo Antonio Cherubini Enrico Mossello David Meagher and 95 more Andrea Mazzone Angelo Bianchetti Nicola Ferrara Alberto Ferrari Massimo Musicco Marco Trabucchi Giuseppe Bellelli Stefano Boffelli Fabio Di Stefano Francesco De Filippi Fabio Guerini Erik Bertoletti Albert March Alessandro Margiotta Patrizia Mecocci Desirée Addesi Fausto Fantò Giancarlo Isaia Babette Dijik Paola Porrino Antonino Maria Cotroneo G Galli Amalia C. Bruni Bruno Bernardini Carla Corsini Annachiara Cagnin Amedeo Zurlo Giuseppe Barbagallo Maria Lia Lunardelli Emilio Martini Giuseppe Battaglia Raffaele Latella Donatella Petritola Elena Sinforiani Alberto Cester M. Formilan Pasqualina Carbone Ildebrando Appollonio Diletta Cereda Lucio Tremolizzo E. Bottacchi Lucio Lucchetti Claudio Mariani P Rapazzini Giuseppe Romanelli Alessandra Marengoni Giovanni Zuliani Lara Bianchi Teresa Suardi Ettore Muti Renato Bottura Giovanni Sgrò Antonella Mandas Luca Serchisu Patrizia Crippa Claudio Ivaldi Andrea Ungar Daniele Villani Clara Raimondi Chiara Mussi Giancarlo Isaia G. Provenzano Daniela Mari Patrizio Odetti Fiammetta Monacelli Raffaele Antonelli Incalzi Alice Pluderi Claudio Bellamoli L Terranova Elio Scarpini Ferdinando D’Amico Maria Chiara Cavallini Gianbattista Guerrini Anna Maria Scotuzzi Antonino Chiarello Alberto Pilotto Sara Tognini Giuseppina Dell’Aquila G. Toigo Giuliano Ceschia Maristella Piccinini Andrea Fabbo Marco Zoli Paola Forti Christian Wenter Giorgio Basile Anna Lasagni Alessandro Padovani Luca Rozzini Maria Cottino Silvia Vitali Gabriele Tripi Stefano Avanzi Simona Umidi Daniela Moretti

10.1016/j.jagp.2017.05.003 article EN American Journal of Geriatric Psychiatry 2017-05-04

Virtual reality (VR) has recently emerged as a promising means for the administration of cognitive training seniors at risk dementia. Immersive VR could result in increased engagement and performances; however, its acceptance older adults with deficits still to be assessed. To assess usability an immersive environment requiring real walking active participants' interaction. 58 mild impairment (MCI, n = 24) or subjective decline (SCD, 31) performed shopping task virtual supermarket displayed...

10.3233/jad-201431 article EN Journal of Alzheimer s Disease 2021-02-19

Abstract Background Healthcare workers represent one of the most affected categories by adverse effects COVID-19 pandemic on mental health. Excessive stress and anxiety are critical factors that could compromise work performance. Besides, high levels may have long-term physical psychological consequences. Recent studies investigated virtual reality to reduce among healthcare during pandemic. However, proposed interventions important limitations related their location (i.e., research lab...

10.1186/s13063-022-06337-2 article EN cc-by Trials 2022-06-02

Tobacco smoke exposure (TSE) is a worldwide health problem and it considered risk factor for pregnant women's children's health, particularly respiratory morbidity during the first year of life. Few significant birth cohort studies on effect prenatal TSE via passive active maternal smoking development severe bronchiolitis in early childhood have been carried out worldwide. From November 2009 to December 2012, newborns born at ≥33 weeks gestational age (wGA) were recruited longitudinal...

10.1186/s12931-015-0312-5 article EN cc-by Respiratory Research 2015-12-01

Epilepsy is increasing, being more common in older adults, with than 20% of late-onset cases unknown aetiology (LOEU). Although epilepsy was associated cognitive impairment, few studies evaluated the trajectories decline patients LOEU. The present study aimed at assessing biomarkers Alzheimer's disease (AD) LOEU and evaluating their performance for 12 months. For this study, 55 diagnosed 21 controls were included. Participants underwent evaluation cerebrospinal fluid (CSF) biomarker analysis...

10.1111/ejn.15734 article EN European Journal of Neuroscience 2022-06-09

Introduction The evaluation of memory is a crucial aspect both cognitive research and clinical applications, as it offers valuable insights into an individual’s wellbeing performance. Conventional neuropsychological assessments represent the established method for assessing different aspects memory. Recent technological advancements, specifically in field virtual reality (VR), have introduced novel methods evaluating Objective This systematic review aims to examine current state assessment...

10.3389/fnhum.2024.1380575 article EN cc-by Frontiers in Human Neuroscience 2024-05-16

although frailty and delirium are among the most frequent burdensome geriatric syndromes, little is known about their association impact on short-term mortality.to examine, in hospitalized older persons, whether associated with delirium, these two conditions, alone or combination, affect patients' 30-day survival.observational study nested Delirium Day project, follow-up.acute medical wards (n = 118) rehabilitation 46) Italy.a total of 2,065 individuals aged 65+ years acute (1,484 patients,...

10.1093/ageing/afab042 article EN Age and Ageing 2021-03-26

This study aimed to evaluate the association between polypharmacy and delirium, of specific drug categories with differences in drug-delirium medical surgical units according dementia diagnosis.Data were collected during 2 waves Delirium Day, a multicenter delirium prevalence including patients (aged 65 years or older) admitted acute long-term care wards Italy (2015-2016); this study, only enrolled hospital selected (n = 4,133). was assessed score on 4 "A's" Test. Prescriptions classified by...

10.4088/jcp.18m12430 article EN The Journal of Clinical Psychiatry 2019-03-11

To ensure the continuity of healthcare and to counter spread COVID-19 pandemic, doctors nursing staff at hospitals must face an insidious, invisible danger that is stretching system far past its capacity. Excessive workload, inadequate protection from contamination, need manage patients experiencing extreme suffering being kept apart their families put medical personnel high risk experience stress anxiety. Numerous scientific studies have shown that, among various therapeutic programs,...

10.3389/frvir.2021.620225 article EN cc-by Frontiers in Virtual Reality 2021-02-02

Background/Objectives Delirium is underrecognized in clinical practice. The primary aim of the present multicenter study was to compare ability nurses identify delirium features with a standardized assessment. secondary predictors missed or incorrect identifications by nurses. Design Point prevalence 120 wards across Italy. Setting “Delirium Day 2015.” Participants Inpatients aged 65 and older (N = 1,867). Measurements were asked specific questions investigate their perceptions presence...

10.1111/jgs.15211 article EN Journal of the American Geriatrics Society 2017-12-05
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