A5013093034- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Intensive Care Unit Cognitive Disorders
- Cholinesterase and Neurodegenerative Diseases
- Pharmaceutical Practices and Patient Outcomes
- Dementia and Cognitive Impairment Research
- Anesthesia and Sedative Agents
- Biochemical effects in animals
- Anesthesia and Neurotoxicity Research
- Vitamin D Research Studies
- Diet and metabolism studies
- Delphi Technique in Research
- Cardiovascular Function and Risk Factors
- Medicinal Plants and Bioactive Compounds
- Schizophrenia research and treatment
- Sleep and related disorders
- Cerebrovascular and Carotid Artery Diseases
- Heart Failure Treatment and Management
- Sleep and Wakefulness Research
- Frailty in Older Adults
- Hallucinations in medical conditions
- COVID-19 and Mental Health
- Adipose Tissue and Metabolism
- Conferences and Exhibitions Management
- Biological Research and Disease Studies
Ospedale Maria Vittoria
2020-2024
Medical University Pleven
2020
Finland University
2020
University of Minnesota
2020
True (United States)
2020
ASL Roma
2018
Weatherford College
2015
Hatch (Canada)
2015
Stroke Association
2015
Torino e-district
2004-2014
Background: The studio di intervento nel decadimento vascolare lieve (IDEALE study) was an open multicenter Italian study, the aim of which to assess effectiveness and safety oral citicoline in elderly people with mild vascular cognitive impairment. Methods: study performed 349 patients. active or group composed 265 patients included 122 men 143 women mean age 79.9 ± 7.8 years selected from six regions. Inclusion criteria were ≥ 65 years, Mini-Mental State Examination (MMSE) score 21,...
Background: Citicoline can have beneficial effects both in degenerative and vascular cognitive decline a variety of ways (apoptosis inhibition, neuroplasticity potentiation, phospholipid, acetylcholine (ACh) synthesis). Acetylcholinesterase inhibitors (AChEIs) been used for treatment Alzheimer’s disease (AD). When co-administered with cholinergic precursors, they are able to increase the intrasynaptic levels ACh more than when single drugs given alone. Objective: The aim present study was...
Combined therapy of memantine and acetylcholinesterase inhibitors (AChEIs) in patients with Alzheimer's disease (AD) may be associated higher benefits than either monotherapy.This retrospective multicentric study conducted seven Italian Ambulatory Centers for Dementia assessed the efficacy safety 20 mg/day administered 6 months addition to an AChEI AD worsened cognitive functions behavioral disorders.A total number 240 (61.7% women, 38.3% men, mean age 77.9 ± 7.32 years old) who had started...
Objective: To report a case of visual hallucinations and psychomotor agitation probably induced by an interaction between venlafaxine propafenone. Case Summary: An 85-year-old woman was admitted for evaluation mood disorder on March 20, 2006. Her general practitioner had prescribed sertraline treatment, which started about 6 months earlier. The patient's medical history included hypertension, supraventricular tachycardia, chronic bronchitis, arthritis, she received ramipril, ticlopidine,...
Abstract Backgroung The early identification of cognitive disorder is a primary scope, because it could reduce the rate severe impairment and thus contribute to healthcare costs in next future. Aims present paper aimed build virtuous diagnostic path impairment, highlighting all professionalism that can serve this purpose. Methods Delphi method was used by experts, who reviewed information available during each meeting related following topics: diagnosis definition Mild Cognitive Impairment,...
Citicoline is a naturally occurring compound with pleiotropic effects on neuronal function and cognitive processes.
The aim of the COGNIDAGE study was to examine association between 25(OH)D and cognitive status in a group elderly patients with vitamin D deficiency high burden comorbidities attending Geriatric Outpatient Clinics.We studied relationship functions taking into account assessed by MMSE (Mini Mental State Examination), CDT (Clock Drawing Test) CIRS (Cumulative Illness Rating Scale), 132 consecutive low levels (<10 ng/ml) compatible condition deficiency. among levels, score, score scores were...
Prescription for inappropriate drugs can be dangerous to the elderly due increased risk of adverse drug reactions and drug-interactions. In this manuscript, we report complexity polypharmacy possible harmful consequences in an old person. An 81-year-old man with a clinical history diabetes, blood hypertension, non-valvular atrial fibrillation, chronic obstructive pulmonary disease, osteoarthritis, anxiety, depression, was admitted our attention cognitive disorders dementia. Brain magnetic...
IDEALE study was an Italian open multicentric on mild vascular cognitive impairment whose aim to assess the effectiveness and safety of oral citicoline in elderly people with impairment. This performed 265 patients, 122 men 143 women, mean age 79.9 ± 7.8 years old six regions. Inclusion criteria were ≥ 65 old, MMSE 21, or subjective memory complaints no evidence deficits MMSE, lesions neuroradiology. People probable Alzheimer's disease excluded. Control group composed by 84 36 48 77.9 7.01...
The present article reports an overview of the studies about combination treatment with citicoline Alzheimer's (AD) and mixed dementia (MD).A Medline search was carried out by using keywords dementia, older people, citicoline, memantine, acetylcholinesterase inhibitors (AchEIs).Six were found to match AcheIs and/or memantine. CITIRIVAD CITICHOLINAGE first report potential benefits adding (AchEIs). Then, we added memantine in CITIMEM study, finally, demonstrated terms delay cognitive...
Neurodegeneration is closely linked to neuroinflammation. It often associated with oxidative stress and meaningful changes in cell energy metabolism. Neuroinflammation due non-neuronal activation (microglia, astrocytes, mast cells) proliferation. Also, it pro-inflammatory substances release, able modify synaptic plasticity. Microglia astrocytes lead toxic agent’s release (reactive oxygen species, inflammatory cytokines); however, the final target of this process cholinergic neuron. A number...
Our body consists primarily of water, present in all our tissues, its requirements vary with the type physical activity, age, and environmental temperature. In general, elderly, along a reduced dietary intake, it is verified that there little support liquids high risk dehydration. Several studies have shown patients dementia dehydration higher low intake liquids, generally less than 1500 ml per day, correlated cognitive impairment reduction ability to perform activities daily living....