A5005676328- Exercise and Physiological Responses
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Fibroblast Growth Factor Research
- Sports Performance and Training
- PARP inhibition in cancer therapy
- Thermoregulation and physiological responses
- TGF-β signaling in diseases
- Metabolism, Diabetes, and Cancer
- Cell death mechanisms and regulation
- Tribology and Lubrication Engineering
- Muscle metabolism and nutrition
- Kruppel-like factors research
- Caveolin-1 and cellular processes
- Developmental Biology and Gene Regulation
- RNA modifications and cancer
- Lipoproteins and Cardiovascular Health
- Glycosylation and Glycoproteins Research
- Cancer Cells and Metastasis
- Genetics and Physical Performance
- Metastasis and carcinoma case studies
- NF-κB Signaling Pathways
- Sphingolipid Metabolism and Signaling
- RNA Research and Splicing
IRCCS Ospedale San Raffaele
2024
University of Verona
2019-2022
University of Urbino
2015-2020
Growing evidence points to the effectiveness of flywheel (FW) based iso-inertial resistance training in improving physical performance capacities. However, molecular adaptations induced by FW exercises are largely unknown. Eight resistance-trained men performed 5 sets 10 maximal squats on a device. Muscle biopsies (fine needle aspiration technique) and blood samples were collected before (t0), 2h (t1) after exercise. Blood additionally drawn 24h (t2) 48h (t3). Paired t-tests revealed...
Background: Prognosis of patients affected by metastatic esophageal–gastric junction (EGJ) or gastric cancer (GC) remains dismal. Trastuzumab, an anti-HER2 monoclonal antibody, is the only targeted agent approved for first-line treatment with HER2-overexpressing advanced EGJ GC in combination chemotherapy. However, invariably become resistant during this treatment. We recently identified overexpression fibroblast growth factor (FGF) receptor 3 (FGFR3) as a molecular mechanism responsible...
Insulin-like growth factor-1 (IGF-1) is synthesised as a prohormone (proIGF-1) requiring enzymatic activity to yield the mature IGF-1. Three proIGF-1s are encoded by alternatively spliced IGF-1 mRNAs: proIGF-1Ea, proIGF-1Eb and proIGF-1Ec. These have common sequence but different E-domains. The structure of E-domains has not been resolved, their molecular functions still unclear. Here, we show that Intrinsically Disordered Regions distinct regulatory on production. In particular, identified...
Background.This study evaluates the clinical and biochemical effects of sequential intra-articular (IA) injections linear (LHA) cross-linked hyaluronic acid (CLHA) in patients with Gonarthrosis (GA).Methods.Thirty-nine (39) (age 64.89 ± 8.83) received first LHA injection (0.8-1.2 MDa, 32mg/2ml) after 1 week CLHA (1.0 MDa 2.0 75mg/3ml) one; this round was repeated 6 months.Clinical assessments -i.e.ultrasonography, visual analogic scale (VAS) for pain, range motion (ROM) Western Ontario...
<h3>Background</h3> Retrospective clinical data on melanoma and non-small cell lung cancers have shown that patients taking statins before the onset of checkpoint inhibitors (CPI), a better progression free survival (PFS) overall (OS). Starting from this evidence, we investigated efficacy biologic mechanisms simvastatin plus anti-PD1 in melanoma-baring mice. <h3>Methods</h3> We analyzed PFS OS our cohort metastatic performed vivo experiments to compare effect simvastatin, or combination...
Abstract The TGFβ receptor inhibitor galunisertib (GAL) has been demonstrated as an effective strategy for the treatment of pancreatic cancer (PC) patients, in part through modulation stromal microenvironment. However, alternative pathways driving paracrine signals might impair its effect. Autotaxin (ATX) is enzyme that converts lysophosphatidylcholine into bioactive lipid, lysophosphatidic acid (LPA), which turn promotes inflammation and fibrosis, contributes to resistance. IOA-289 a novel...