A5082112497- Cancer survivorship and care
- Autophagy in Disease and Therapy
- Listeria monocytogenes in Food Safety
- Research on Leishmaniasis Studies
- Growth Hormone and Insulin-like Growth Factors
- Obesity, Physical Activity, Diet
- Essential Oils and Antimicrobial Activity
- Physical Activity and Health
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Probiotics and Fermented Foods
- Trypanosoma species research and implications
- Microbial Inactivation Methods
- Nutrition and Health in Aging
- Endoplasmic Reticulum Stress and Disease
- Genomics, phytochemicals, and oxidative stress
- Phytochemicals and Antioxidant Activities
- Plant Pathogens and Fungal Diseases
- Mitochondrial Function and Pathology
- Nail Diseases and Treatments
- Pneumonia and Respiratory Infections
- Long-Term Effects of COVID-19
- Dietary Effects on Health
- RNA Interference and Gene Delivery
University of Urbino
2016-2025
Array BioPharma (United States)
2021
Autophagy is a cellular mechanism by which cells degrade intracellular components in lysosomes, maintaining homeostasis. It has been hypothesized that autophagy could have role cancer prevention through the elimination of damaged proteins and organelles; this explain epidemiological evidence showing chemopreventive properties autophagy-inducer metformin. In study, we analyzed autophagy-related effect metformin both initiation progression non-tumorigenic cells. We also induction tumorigenesis...
Indole-3-carbinol and its metabolic products are considered promising chemopreventive anticancer agents. Previously we have shown that the indole-3-carbinol cyclic tetrameric derivative CTet induces autophagy inhibits cell proliferation via inhibition of Akt activity overexpression p21/CDKN1A GADD45A, in both estrogen receptor-positive (MCF-7) triple negative (MDA-MB-231) breast cancer lines. In present study, further characterize autophagic response investigate mechanism through which...
Listeria monocytogenes (Lm) is the causative agent of human listeriosis. Lm strains have different virulence potential. For this reason, we preliminarily characterised via Whole-Genome Sequencing (WGS) some for their key genomic features and virulence-associated determinants, assigning clonal complex (CC). Moreover, ability same to adhere invade colon carcinoma cell line Caco-2, evaluating possible correspondence with genetic profile, was also assessed. The clinical typed belonged (CC)1,...
Abstract Aim Ensuring food safety is fundamental to protect public health, especially in domestic environments where handled daily. This two-phase study aimed investigate the efficacy of an ultraviolet-C light emitting diode (UV-C LED) handheld lamp through vitro disinfection tests and on artificially contaminated surfaces. Methods Results The UV-C LED-based was assessed at different initial microbial contamination titers several UV doses, both ATCC, foodborne, clinical strains were...
ABSTRACT Insulin‐like growth factor‐1 (IGF‐1) is critical for tissue and development. The IGF‐1 gene contains six exons due to alternative splicing three different isoforms might be produced: the IGF‐1Ea, Eb, Ec prohormones (proIGF‐1s). These proIGF‐1s share same mature sequence, which responsible receptor binding but differ in their carboxy‐terminal extensions called Ea‐, Eb‐, Ec‐peptides. Several lines of evidence indicate that E‐peptides control intracellular localization maturation....
Abstract A growing number of people attend swimming facilities for recreational activities, rehabilitative treatments, or sport. Filamentous fungi and yeast can be isolated from contaminated air, water surfaces may represent a biological risk employees users. Here we investigated the occurrence mycotic species, in sample Italian pools (n = 10). Detection identification species were achieved by cultural morphological methods. Results revealed moderate titres high biodiversity. Penicillium...
Purpose The aim of this study was to evaluate the antiproliferative activity in breast cancer cells and inhibition tumorigenesis pre-neoplastic a new apple cultivar with reddish pulp, called Pelingo apple. Methods evaluated MCF-7 MDA-MB-231 human cells. performed JB6 promotion-sensitive (P+) Results showed that juice is characterized by very high polyphenol content strongly inhibited cell proliferation. Its found be higher than other five juices tested. induced accumulation G2/M phase cycle...
The Leishmaniases are a group of parasitic diseases caused by protozoa the Leishmania genus affecting both humans and other vertebrates. is an intracellular pathogen able to confer resistance apoptosis in early phase macrophages infection activation host PI3K/Akt pathway inhibition caspase-3 activation. Intracellular pathogens hijack organelles such as ER facilitate survival replication, thus eliciting stress activating/modulating unfolded protein response (UPR) cell. UPR aimed mitigate...
Indole-3-carbinol (I3C), an autolysis product of glucosinolates present in cruciferous vegetables, and its dimeric derivative (3,3'-DIM) have been indicated as promising agents preventing the development progression breast cancer. We recently shown that I3C cyclic tetrameric CTet formulated γ-cyclodextrin (γ-CD) efficiently inhibited cellular proliferation cancer cell lines. This study aims to analyze mechanisms involved vitro inhibition evaluate vivo antitumor activity a xenograft...
The rapid and expedient assembly of three new classes biheterocycles biological interest, viz. indole–imidazoles 4 , indole–pyrroles 6 indole–triazoles 8 was accomplished using different combinations tryptamines, 1,2‐diaza‐1,3‐dienes, aldehydes, and/or alkynes as readily available building blocks. Twenty‐six derivatives were thus prepared in excellent yields (up to 100 %). products screened for in‐vitro studies. Some these revealed promising anticancer activity against MCF7 Caco‐2 human...
During the last decades, an important modification of dietary habits has been observed in Mediterranean countries, especially among young people. The aim this study was to evaluate adherence diet (MedDiet) and its relationship with weight status a group Italian middle school adolescents by using KIDMED test. evaluation revealed that 61.5, 26.8, 11.7% were normal weight, overweight, obese, respectively. MedDiet high 13.3%, average 27.1%, low 59.6% students no differences gender age. found...
Circulating insulin-like growth factor-1 (IGF-1) is positively associated with the risk of BC recurrence, and more frequently dysregulated in older people, especially those metabolic syndrome (MetS) obesity. This study aimed to analyze association between IGF-1 levels indices MetS insulin resistance survivors.Baseline data 563 survivors enrolled DIet ANdrogen-5 (DIANA-5; NCT05019989) were analyzed.Lower circulating subjects than without found. After stratification patients according...
Leishmaniasis is an anthropo-zoonotic disease caused by various Leishmania species. The clinical manifestations of the vary according to species and host characteristics. infection leads subversion/modulation host's innate immune response cellular metabolic pathways. In last years, it has been shown that many cell gene expression signaling pathways are targeted subvert defenses (e.g., oxidative damage, activation, antigen presentation, apoptosis) allow parasite survival replication. However,...
Insulin-like growth factor-1 (IGF-1) is synthesised as a prohormone (proIGF-1) requiring enzymatic activity to yield the mature IGF-1. Three proIGF-1s are encoded by alternatively spliced IGF-1 mRNAs: proIGF-1Ea, proIGF-1Eb and proIGF-1Ec. These have common sequence but different E-domains. The structure of E-domains has not been resolved, their molecular functions still unclear. Here, we show that Intrinsically Disordered Regions distinct regulatory on production. In particular, identified...
Abstract Background Breast cancer (BC) is the most common invasive in women, and exercise can significantly improve outcomes of BC survivors. MoviS (Movement Health Beyond Care) a randomized controlled trial aimed to evaluate potential health benefits proper nutritional habits. This study aims assess efficacy aerobic training improving quality life (QoL) health-related factors high-risk BC. Methods One hundred seventy-two survivor aged 30–70 years, non-metastatic, stage 0–III, non-physically...