Abstract Background Apples are an important source of polyphenols in the human diet and consumption this fruit has been linked to prevention degenerative diseases. Results Catechins, procyanidins, hydroxycinnamic acids, flavonol glycosides, dihydrochalcone glycosides one anthocyanin: cyanidin-3-O-galactoside, were identified both peel pulp. Procyanidins, catechins flavonols represent main constituents peel. Concerning antioxidant activity, reduction stable DPPH radical inhibition lipid...

Among the non-neurological functions of melatonin, much attention is being directed to ability melatonin modulate immune system, whose cells possess melatonin-specific receptors and biosynthetic enzymes. Melatonin controls cell behaviour by eliciting specific signal transduction actions after its interaction with plasma membrane (MT(1), MT(2)); additionally, potently neutralizes free radicals. regulates loss antagonizing apoptosis. A major unsolved question whether this due receptor...

Purpose The aim of this study was to evaluate the antiproliferative activity in breast cancer cells and inhibition tumorigenesis pre-neoplastic a new apple cultivar with reddish pulp, called Pelingo apple. Methods evaluated MCF-7 MDA-MB-231 human cells. performed JB6 promotion-sensitive (P+) Results showed that juice is characterized by very high polyphenol content strongly inhibited cell proliferation. Its found be higher than other five juices tested. induced accumulation G2/M phase cycle...

Abstract The chemical composition of the essential oil obtained from Monarda didyma stem with leaves and flowers was analyzed by GC GC/MS components identified were 22, mainly thymol (57.3% 51.7%, respectively), γ-terpinene (9.3% 14.3%), p-cymene (10.5% 9.7%), δ-3-carene (4.5% 6.2%) myrcene (3.7% 3.7%). two oils qualitatively similar. antifungal activity evaluated against four phytopathogenic fungi direct contact Agar diffusion method fungistatc action vapors using Micro-atmosphere method....

The antioxidant activity was assessed of fresh juice from Prunus spinosa L. fruit (Rosaceae) growing wild in Urbino (central Italy) by using different cell-free vitro analytical methods: 5-lipoxygenase test, 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging, and oxygen absorbance capacity (ORAC). Trolox used as the reference compound. In DPPH tests P. showed good when compared with Trolox, while ORAC value 36.0 μmol eq. /g fruit. These values are accord data reported literature...

The total phenolic content, antioxidant and antifungal activities of three Inula crithmoides extracts (n-hexane, methylene chloride MeOH) were investigated. methanolic extract showed the highest content. In DPPH assay, hexane exhibited DPPH-radical scavenging activity; in 5-lipoxygenase greater inhibitory effect with an IC50 similar to that Trolox ascorbic acid. activity revealed a higher against Phytophtora cryptogea Alternaria solani.

The chemical composition of the essential oil obtained from aerial parts Inula crithmoides L. was analyzed by GC and GC/MS 22 components were identified, major ones being p-cymene (30.1%), 1-methylethyl-trimethylbenzene (18.7%), scopoletin (15.3%) alpha-pinene (13.1%). antioxidant activity evaluated DPPH test 5-lipoxygenase assay. exerted a good in protection lipid peroxidation when compared with known antioxidants.

Mammalian red blood cell α‐spectrin is ubiquitinated in vitro and vivo [Corsi, D., Galluzzi, L., Crinelli, R., Magnani, M. (1995) J. Biol. Chem . 270 , 8928–8935]. This process shows a age‐dependent decrease, with senescent cells having approximately one third of the amount found young cells. In‐vitro ubiquitination was dependent on source membranes (those from older are less susceptible to than those younger cells), ubiquitin‐conjugating enzymes catalyze at reduced rate compared cells)...

The chemical composition of the essential oil Ballota nigra L. ssp foetida obtained from flowering aerial parts was analyzed by GC/MS. From 37 identified constituents oil, beta-caryophyllene (20.0%), germacrene D (18.0%) and caryophyllene oxide (15.0%) were major components. active against both Gram-negative Gram-positive bacteria as well three Candida species.

By bioguided fractionation of the hexane extract Commiphora erythraea resin we isolated four furanosesquiterpenoids that were tested for their protective activity against oxidative stress. Furanodienone and 1,10(15)-furanogermacra-dien-6-ones showed to be potent inhibitors lipid peroxidation (IC50 ~0.087 μM), being more active than methoxylated analogues. Furthermore, using BV2 microglial cells, found furanodienone from C. is able counteract LPS-induced cell death decrease NO generation thus...

This is the first report on antioxidant and antifungal activities of callus cultures from Inula crithmoides L. (Asteraceae). Callus were initiated leaf sections, initial culture MS basal medium supplemented with various concentrations 2,4-D (2,4-dichlorophenoxyacetic acid), NAA (1-naphthaleneacetic acid) IBA (indole-3-butyric a 72% survival was achieved. Significant differences between auxins used as phytohormones growth found. Maximum callusing noticed explants grown 1 mgL(-1) 2,4-D....

Brassica villosa subsp. drepanensis (Caruel) Raimondo & Mazzola, belonging to the oleracea complex, is a wild edible plant endemic western Sicily and relative of modern cultivated crops. In this study, antioxidant properties, anti-inflammatory activities, enzymatic inhibition, cytotoxicity in cancer cells B. leaf ethanolic extract were analysed for first time. addition, its chemical profile was investigated partitioning total 70% ethanol among ethyl acetate, n-butanol, water obtain three...

Boropinic acid and other natural prenyloxycinnamic benzoic acids were easily synthesized in high yield by a two-step sequence from the corresponding p-hydroxy aromatic assayed for radical scavenging activity using DPPH test inhibition of enzymatic lipid peroxidation mediated soybean 5-lipoxygenase. Compared to known antioxidant compounds like BHT, Trolox ascorbic acid, boropinic was far more active lipoxygenase (IC 50 = 7.6 ng/mL, p < 0.05). The recorded value suggested that acted as an...

Rutaceae are widely used in ethnomedicine to treat infectious diseases humans and plants. In this study, the antifungal activity of Vepris macrophylla leaf essential oil (VEO) its main components, citral citronellol, was evaluated against six phytopathogenic fungi. addition, possible action VEO on synthesis mycotoxins as well. To determine we agar dilution method showed inhibitory all tested particular, resulted be fungicidal Phytophthora cryptogea Fusarium avenaceum. For other fungi...

The total phenolic content and antioxidant activity of 6 Salvia spp. exudates were measured to find new potential sources natural antioxidants. Total was assessed by a modified Prussian blue method, the two methods: 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging capacity assay lipoxygenase inhibitory assay. ranged between 1.3 microg/mg DW (S. fallax) 74.0 cacaliaefolia). In DPPH test, S. cacaliaefolia more effective than BHT, while in inhibition lipid peroxidation all extracts...