A5075093036- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Metabolism and Genetic Disorders
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Metabolism, Diabetes, and Cancer
- Enzyme function and inhibition
- Computational Drug Discovery Methods
- Ubiquitin and proteasome pathways
- SARS-CoV-2 detection and testing
- Ginseng Biological Effects and Applications
- Amyotrophic Lateral Sclerosis Research
- SARS-CoV-2 and COVID-19 Research
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects of Natural Compounds
- Sesquiterpenes and Asteraceae Studies
- Dye analysis and toxicity
- Saffron Plant Research Studies
- Phytochemical and Pharmacological Studies
- Animal Virus Infections Studies
- Microbial Metabolites in Food Biotechnology
- Tannin, Tannase and Anticancer Activities
- RNA regulation and disease
- Cytokine Signaling Pathways and Interactions
University of Calabria
2015-2024
University of Bari Aldo Moro
2006-2010
University of Lausanne
2010
University of Urbino
2007
Inflammation represents an adaptive response generated by injuries or harmful stimuli. Natural remedies represent interesting alternative to traditional therapies, involving several biochemical pathways. Besides, the valorization of agrochemical wastes nowadays seems be a feasible way reduce health spending and improve accessibility at bioactive natural compounds. In this context, chemical composition three Glycyrrhiza glabra L. (licorice) leaf extracts, obtained through maceration...
The saturated medium-chain fatty-acid lauric acid (LA) has been associated to certain health-promoting benefits of coconut oil intake, including the improvement quality life in breast cancer patients during chemotherapy. As it concerns potential hamper tumor growth, LA was shown elicit inhibitory effects only colon cells. Here, we provide novel insights regarding molecular mechanisms through which triggers antiproliferative and pro-apoptotic both endometrial In particular, our results...
Thalidomide was first used for relief of morning sickness in pregnant women and then withdrawn from the market because its dramatic effects on normal fetal development. Over last decades, it has been successfully treatment several pathologies, including cancer. Many analogues with improved activity have synthesized tested. Herein we report some growth progression MCF-7 MDA-MB-231 breast cancer cells by a small series thalidomide-correlated compounds, which are very effective at inducing cell...
Thioalbamide, a thioamidated peptide biosynthesized by Amycolatopsis alba, is thioviridamide-like molecule, and part of family natural products representing focus biotechnological pharmaceutical research in recent years due to their potent anti-proliferative cytotoxic activities on malignant cells. Despite the high antitumor potential observed at nanomolar concentrations, mechanisms underlying thioalbamide activity are still not known. In this work, cellular effects induced treatment breast...
Background: Prostate cancer (PCa) is the second leading cause of cancer-related deaths in men. Although prostate-specific antigen (PSA) test used clinical practice for screening and/or early detection PCa, it not specific, thus resulting high false-positive rates. MicroRNAs (miRs) provide an opportunity as biomarkers diagnosis, prognosis, and recurrence PCa. Because size literature on increasing often controversial, this study aims to consolidate state-of-art relevant published research....
Oxazolidinones are antibiotics that inhibit protein synthesis by binding the 50S ribosomal subunit. Recently, numerous worldwide researches focused on their properties and possible involvement in cancer therapy have been conducted. Here, we evaluated vitro antiproliferative activity of some 5-(carbamoylmethylene)-oxazolidin-2-ones MCF-7 HeLa cells. The tested compounds displayed a wide range cytotoxicity these cell lines, measured MTT assay, exhibiting no non-tumorigenic MCF-10A Among nine...
Uncoupling proteins (UCPs) form a distinct subfamily of the mitochondrial carrier family (MCF) SLC25. Four UCPs, DmUCP4A-C and DmUCP5, have been identified in Drosophila melanogaster on basis their sequence homology with mammalian UCP4 UCP5. In Parkinson's disease model, DmUCP4A showed protective role against dysfunction, by increasing membrane potential ATP synthesis. To date, is still an orphan biochemical function, although its possible involvement uncoupling has ruled out. Here, we show...
The mitochondrial carriers are a family of transport proteins that shuttle metabolites, nucleotides and cofactors across the inner membrane. genome Drosophila melanogaster encodes at least 46 members this family. Only five these have been characterized, whereas functions remainder cannot be assessed with certainty. In present study, we report functional identification two D. genes distantly related to human yeast thiamine pyrophosphate carrier (TPC) as well corresponding expression pattern...
Research on the energy metabolism of cancer cells is becoming a central element in oncology, and recent decades, it has allowed us to better understand mechanisms underlying onset chemoresistance oncological pathologies. Mitochondrial bioenergetic processes, particular, have proven be fundamental for survival tumor stem (CSC), subpopulation responsible recurrence, metastasis, failure conventional anticancer therapies. Over years, numerous natural products, particular flavonoids, widely...
Several ATP-depending reactions take place in the endoplasmic reticulum (ER). Although Saccharomyces cerevisiae ER existence of a Sac1p-dependent ATP transport system was already known, its direct involvement excluded. Here we report an extensive biochemical characterization partially purified adenine nucleotide (ANTS) not dependent on Sac1p. Highly membranes from wild-type and Δsac1 yeast strains reconstituted into liposomes transported with same efficiency. A chromatography hydroxyapatite...