A5078606785- Pancreatic and Hepatic Oncology Research
- Sphingolipid Metabolism and Signaling
- Caveolin-1 and cellular processes
- Cancer Cells and Metastasis
- Immune cells in cancer
- Kruppel-like factors research
- TGF-β signaling in diseases
- Pancreatitis Pathology and Treatment
- NF-κB Signaling Pathways
- Cell death mechanisms and regulation
- Cell Adhesion Molecules Research
- Cancer, Hypoxia, and Metabolism
University of Verona
2021-2024
Abstract The TGFβ receptor inhibitor galunisertib demonstrated efficacy in patients with pancreatic ductal adenocarcinoma (PDAC) the randomized phase II H9H-MC-JBAJ study, which compared plus chemotherapeutic agent gemcitabine alone. However, additional stromal paracrine signals might confer adaptive resistance that limits of this therapeutic strategy. Here, we found autotaxin, a secreted enzyme promotes inflammation and fibrosis by generating lysophosphatidic acid (LPA), mediates to...
<p>Figures S1-5, Tables S1-3</p>
<p>Figures S1-5, Tables S1-3</p>
<div>Abstract<p>The TGFβ receptor inhibitor galunisertib demonstrated efficacy in patients with pancreatic ductal adenocarcinoma (PDAC) the randomized phase II H9H-MC-JBAJ study, which compared plus chemotherapeutic agent gemcitabine alone. However, additional stromal paracrine signals might confer adaptive resistance that limits of this therapeutic strategy. Here, we found autotaxin, a secreted enzyme promotes inflammation and fibrosis by generating lysophosphatidic acid (LPA),...
<div>Abstract<p>The TGFβ receptor inhibitor galunisertib demonstrated efficacy in patients with pancreatic ductal adenocarcinoma (PDAC) the randomized phase II H9H-MC-JBAJ study, which compared plus chemotherapeutic agent gemcitabine alone. However, additional stromal paracrine signals might confer adaptive resistance that limits of this therapeutic strategy. Here, we found autotaxin, a secreted enzyme promotes inflammation and fibrosis by generating lysophosphatidic acid (LPA),...
Abstract The TGFβ receptor inhibitor galunisertib (GAL) exhibited promising efficacy in patients with pancreatic ductal adenocarcinoma (PDAC) the randomized phase 2 H9H-MC-JBAJ study. However, identification of predictive biomarkers remains unique importance. We used a 279 multi-analyte panel and confirmed CCL3 as most significant plasma protein for chemoresistance receiving gemcitabine (GEM) [overall survival (mOS) (95%CI), high vs low, 3.6 (2.5-4.0) 10.1 (7.2-17.0) months, HR (95%CI)= 3.92...
Abstract The TGFβ receptor inhibitor galunisertib (GAL) has been demonstrated as an effective strategy for the treatment of pancreatic cancer (PC) patients, in part through modulation stromal microenvironment. However, alternative pathways driving paracrine signals might impair its effect. Autotaxin (ATX) is enzyme that converts lysophosphatidylcholine into bioactive lipid, lysophosphatidic acid (LPA), which turn promotes inflammation and fibrosis, contributes to resistance. IOA-289 a novel...