A5012765772- SARS-CoV-2 and COVID-19 Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Asthma and respiratory diseases
- Smoking Behavior and Cessation
- Sexual function and dysfunction studies
- Pancreatic and Hepatic Oncology Research
- Inhalation and Respiratory Drug Delivery
- Anesthesia and Sedative Agents
- Nicotinic Acetylcholine Receptors Study
- Stress Responses and Cortisol
- Sexuality, Behavior, and Technology
- Olfactory and Sensory Function Studies
- Vitamin D Research Studies
- Sphingolipid Metabolism and Signaling
- vaccines and immunoinformatics approaches
- Neuroendocrine Tumor Research Advances
- Fibroblast Growth Factor Research
- Pharmaceutical Economics and Policy
- Microscopic Colitis
- Immunotherapy and Immune Responses
- Sexual Differentiation and Disorders
- Mental Health Research Topics
- Adrenal Hormones and Disorders
- Amyotrophic Lateral Sclerosis Research
- Veterinary Pharmacology and Anesthesia
Centro Ricerche FIAT
2020-2024
University of Verona
2008-2023
Azienda Ospedaliera Universitaria Integrata Verona
2020-2023
GlaxoSmithKline (United Kingdom)
2002-2005
GlaxoSmithKline (Netherlands)
2005
GlaxoSmithKline (Italy)
1996-2003
To evaluate the postoperative analgesic efficacy of GW842166, a noncannabinoid CB2 agonist, in patients undergoing third molar tooth extraction.This randomized, double-blind, placebo-controlled study compared single doses GW842166 (100 or 800 mg) ibuprofen with placebo extraction at least 1 fully partially impacted tooth. Eligible participants were dosed preoperatively within hour surgery. Participants allocated to active comparator received second dose (400 mg), 4 hours after first mg dose....
The neurite outgrowth inhibitor, Nogo-A, has been shown to be overexpressed in skeletal muscle amyotrophic lateral sclerosis (ALS); it is both a potential biomarker and therapeutic target. We performed double-blind, two-part, dose-escalation study, subjects with ALS, assessing safety, pharmacokinetics (PK) functional effects of ozanezumab, humanized monoclonal antibody against Nogo-A. In Part 1, 40 were randomized (3∶1) receive single dose intravenous ozanezumab (0.01, 0.1, 5, or 15 mg/kg)...
Autotaxin-lysophosphatidic acid (ATX-LPA) signaling has a predominant role in immunological and fibrotic processes, including cancer. Several ATX inhibitors LPA receptor antagonists have been clinically evaluated, but none patients with solid tumors. Many cancers are burdened high degree of fibrosis an immune desert phenotype (so-called 'cold' tumors). In these cold tumors, the stroma provides intrinsic cancer-supporting mechanism. Furthermore, prevents penetration limits effectiveness...
Combination analgesics are effective in acute pain, and a theoretical framework predicts efficacy for combinations. The combination of dexketoprofen tramadol is untested, but predicted to be highly effective. This was randomised, double-blind, double-dummy, parallel-group, placebo-controlled, single-dose trial patients with moderate or severe pain following third molar extraction. There were ten treatment arms, including trometamol (12.5 mg 25 mg) hydrochloride (37.5 75 mg), given as four...
Objectives To compare efficacy/safety of oral tramadol 75 mg/dexketoprofen 25 mg (TRAM/DKP) and TRAM mg/paracetamol 650 (TRAM/paracetamol) in moderate to severe pain following surgical removal impacted lower third molar. Design Multicentre, randomised, double-blind, placebo-controlled, phase IIIb study. Participants Healthy adult patients scheduled for extraction at least one fully/partially molar requiring bone manipulation. 654 were randomised 653 eligible analysis. Interventions Surgery...
the aim of this study was to investigate pharmacokinetic (PK) and safety profile high-dose vitamin D supplementation, comparing different schedules (daily, weekly, or bi-weekly) in an otherwise healthy D-deficient population. Methods: single-center, open-label on subjects deficient (25 (OH)D < 20 ng/mL), randomized receive cholecalciferol (DIBASE®, Abiogen Pharma, Italy) using three schedules: Group A: 10,000 IU/day for eight weeks followed by 1000 four weeks; B: 50,000 IU/week 12 weeks, C:...
Background: Prognosis of patients affected by metastatic esophageal–gastric junction (EGJ) or gastric cancer (GC) remains dismal. Trastuzumab, an anti-HER2 monoclonal antibody, is the only targeted agent approved for first-line treatment with HER2-overexpressing advanced EGJ GC in combination chemotherapy. However, invariably become resistant during this treatment. We recently identified overexpression fibroblast growth factor (FGF) receptor 3 (FGFR3) as a molecular mechanism responsible...
GRAd-COV2, a candidate vaccine for COVID-19 based on gorilla adenovirus, is safe and immunogenic in younger older adults.
Aims To establish whether enantioselective metabolism of racemic ( rac )‐salbutamol occurs in the lungs by determining its enantiomeric disposition following inhalation, absence and presence oral charcoal, compared with that intravenous routes. Methods Fifteen healthy subjects (eight male) were randomized into an open design, crossover study. Plasma urine salbutamol enantiomer concentrations measured for 24 h (2 mg) or without charcoal (to block absorption), inhaled (MDI; 1200 μg) (500...
ABSTRACT In a single-center, randomized study, zanamivir (Relenza) concentrations in induced sputum samples and nasal washings of healthy adults following oral inhalation were measured. Concentrations exceeded the median viral neuraminidase 50% inhibitory concentration at 6, 12, 24 h, those did so 6 12 h. There no zanamivir-related adverse events or laboratory abnormalities.
Here we report on the humoral and cellular immune response in eight volunteers who autonomously chose to adhere Italian national COVID-19 vaccination campaign more than 3 months after receiving a single-administration GRAd-COV2 vaccine candidate context of phase-1 clinical trial. We observed clear boost both binding/neutralizing antibodies as well T-cell responses upon receipt heterologous BNT162b2 or ChAdOx1-nCOV19 vaccines. These results, despite limitation small sample size, support...
The COVID-19 pandemic and the need for additional safe, effective, affordable vaccines gave new impetus into development of vaccine genetic platforms. Here we report findings from phase 1, first-in-human, dose-escalation study COVID-eVax, a DNA encoding receptor binding domain (RBD) SARS-CoV-2 spike protein. Sixty-eight healthy adults received two doses 0.5, or 2 mg 28 days apart, single 2-mg dose, via intramuscular injection followed by electroporation, they were monitored 6 months. All...
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and heterologous immunization approaches implemented worldwide for booster doses call diversified vaccine portfolios. GRAd-COV2 is a gorilla adenovirus-based COVID-19 candidate encoding prefusion-stabilized spike. safety immunogenicity of evaluated in dose- regimen-finding phase trial (COVITAR study, ClinicalTrials.gov: NCT04791423) whereby 917 eligible participants are randomized to receive single...
The present study is aimed at characterizing the carbon dioxide (CO 2 ) procedure in healthy subjects to achieve reliable provocation of anxiety symptoms. Thirty inhaled single-blind both compressed air and 7% CO mixture. Panic Symptom List (PSLIII-R), Visual Analogue Scale-Anxiety (VAS-A), State Anxiety Inventory (STAI-Y/1), respiratory parameters skin conductance were measured. ‘Responders’ classified depending on PSLIII-R scores after . Twelve out 21 ‘responders’ performed a second test...
Stress affects the immune system and intestinal microbiota composition can lead to imbalance between pro- anti-inflammatory cytokines or uncontrolled production of cytokines. The effect emotional stress on secretory IgA levels also indicates that decreases mucosal integrity. Our aim was evaluate whether a probiotic product (Lactoflorene® Plus) prevent alterations in response associated with self-reported composition. Healthy adult volunteers who psychological were enrolled randomised into...
Upfront surgery followed by postoperative treatment is a commonly adopted for resectable pancreatic ductal adenocarcinoma (rPDAC). However, the risk of positive surgical margins, poor recovery that often impairs treatments, and recurrence might limit outcome this strategy. This study evaluated safety activity liposomal irinotecan 50 mg/m2 + 5-fluorouracil 2400 leucovorin 400 oxaliplatin 60 (NALIRIFOX) in perioperative patients with rPDAC.Eligible had rPDAC < 180° interface major veins' wall....
Aims To investigate whether saliva is a useful alternative to plasma for routine monitoring of nicotine and evaluate the predictive performances concentration on craving estimated by Tiffany Questionnaire Smoking Urge‐Brief Form. Methods Thirteen healthy smokers were enrolled in randomized, two period, crossover trial. Linear power models evaluated predict concentrations from measurements, whereas population PK/PD indirect response model was used using either or as independent variable....