A5035904217- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Nanoparticle-Based Drug Delivery
- Thyroid Disorders and Treatments
- RNA Interference and Gene Delivery
- Sexual Differentiation and Disorders
- Advanced biosensing and bioanalysis techniques
- Diabetes Treatment and Management
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Food Allergy and Anaphylaxis Research
- Growth Hormone and Insulin-like Growth Factors
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Endoplasmic Reticulum Stress and Disease
- RNA regulation and disease
- Allergic Rhinitis and Sensitization
- Nanoplatforms for cancer theranostics
- Thyroid Cancer Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- Radiopharmaceutical Chemistry and Applications
- Asthma and respiratory diseases
- Adrenal Hormones and Disorders
- Hormonal and reproductive studies
- Celiac Disease Research and Management
- Pharmaceutical studies and practices
University of Messina
2016-2025
Istituto Ortopedico Gaetano Pini
2019-2025
Eligo Bioscience (France)
2025
Politecnico di Milano
2024
Institut des Sciences Moléculaires d'Orsay
2016-2022
Université Paris-Saclay
2016-2022
Centre National de la Recherche Scientifique
2016-2022
Virtual High School
2022
Weatherford College
2022
Université Paris-Sud
2016-2021
To describe the diabetes phenotype in Wolfram syndrome compared with type 1 diabetes, to investigate effect of glycemic control on neurodegenerative process, and assess genotype-phenotype correlation.The clinical data 50 patients syndrome-related (WSD) were reviewed 24,164 diabetes. Patients a mean HbA1c during childhood adolescence ≤7.5 >7.5% respect occurrence additional symptoms. The wolframin (WFS1) gene was screened for mutations 39 patients. WFS1 genotypes examined correlation age at...
An etiologic diagnosis of diabetes can affect the therapeutic strategy and prognosis chronic complications. The aim present study was to establish relative percentage different subtypes in patients attending Italian pediatric centers influence an on therapy. This a retrospective study. clinical records 3781 consecutive (age, 0 18 years) referred 15 clinics with or impaired fasting glucose from January 1, 2007 December 31, 2012 were examined. characteristics at their first referral centers,...
Dual stimuli-sensitive mixed polymeric micelles (MM) are developed for co-delivery of the endogenous tumor suppressor miRNA-34a and chemotherapeutic agent doxorubicin (Dox) into cancer cells. The novelty system resides in two prodrugs, a matrix metalloproteinase 2 (MMP2)-sensitive Dox conjugate reducing (glutathione, GSH)-sensitive conjugate, self-assembled single particle decorated with polyethylene glycol corona longevity, cell-penetrating peptide (TATp) enhanced intracellular delivery....
Abstract Background The year 2020 will be remembered as the “year of COVID-19 pandemic”. world population had to familiarize themselves with words swabs, personal protective equipment, pandemic. To curb wave pandemic, almost all countries imposed self-isolation and social distancing. We conducted a web-based survey investigate behavioural responses during quarantine due Methods Participants were 1860 youth aged 12–18 years attending lower secondary schools upper schools. Data collected on...
Introduction. To evaluate time in tight range (TITR) 70-140 mg/dL (3.9- 7.8 mmol/L), its correlation with standard continuous glucose monitoring (CGM) metrics and the clinical variables that possibly have a substantial impact on value, large cohort of pediatric subjects using different treatment strategies. Material methods. A total 854 children adolescents type 1 diabetes were consecutively recruited this real-world, dual-center, cross-sectional study. Participants categorized into four...
Background: The aim of this multicenter observational real-world study was to investigate glycemic outcomes in children and adolescents with type 1 diabetes over the first 6-month use MiniMed™ 780G. secondary objective evaluate demographic clinical factors that may be significantly associated achievement therapeutic goals. Methods: Demographic, anamnestic, data participants were collected at time enrollment. Data on ambulatory glucose profile acquired 3 6 months after activating automatic...
OBJECTIVE To investigate glucose metrics and identify potential predictors of the achievement glycemic outcomes in children adolescents during their first 12 months MiniMed 780G use. RESEARCH DESIGN AND METHODS This multicenter, longitudinal, real-world study recruited 368 with type 1 diabetes (T1D) starting SmartGuard technology between June 2020 2022. Ambulatory profile data were collected a 15-day run-in period (baseline), 2 weeks after automatic mode activation, every 3 months. The...
Ovarian cancer is a dreadful disease estimated to be the second most common gynecologic malignancy worldwide. Its current therapy, based on cytoreductive surgery followed by combination of platinum and taxanes, frequently complicated onset multidrug resistance (MDR). The discovery that survivin, small antiapoptotic protein, involved in chemoresistance provided new prospect overcome MDR cancer, because siRNA could used inhibit expression survivin cells. With this mind, we have developed...
Tuberculosis (TB) is a leading infectious cause of death worldwide. The use ethionamide (ETH), main second line anti-TB drug, hampered by its severe side effects. Recently discovered "booster" molecules strongly increase the ETH efficacy, opening new perspectives to improve current clinical outcome drug-resistant TB. To investigate simultaneous delivery and booster BDM41906 in lungs, we co-encapsulated these compounds biodegradable polymeric nanoparticles (NPs), overcoming bottlenecks...
// Manuela Porru 1 , Silvia Zappavigna 2 Giuseppina Salzano 3 Amalia Luce Antonella Stoppacciaro Maria Luisa Balestrieri Simona Artuso Sara Lusa Giuseppe De Rosa Carlo Leonetti and Michele Caraglia Experimental Chemotherapy Laboratory, Regina Elena National Cancer Institute, Via delle Messi d’oro, Rome, Italy Department of Biochemistry, Biophysics General Pathology, Second University Naples, Costantinopoli, Pharmacy, Naples Federico II, Montesano, Correspondence: email: Caraglia,...
Abstract Background Diabetic ketoacidosis (DKA) is one of the most alarming concerns in management type 1 diabetes (T1D) pediatric age. Prevalence DKA at onset ranges from 30 to 40%. In selected cases severe DKA, admission intensive care unit (PICU) should be considered. Methods This study aims assess prevalence treated PICU our 5-year monocentric experience. Secondary outcome was describe main demographical and clinical features individuals who required PICU. All data were collected by...
We investigated the effects of normal variations in maternal glycemia on birth size and other outcomes.
Objectives: Drug delivery systems consisting of liposomes displaying a cell surface receptor-targeting peptide are being developed to specifically deliver chemotherapeutic drugs tumors overexpressing target receptor. This study addresses novel liposome composition approaches tissues bombesin (BN) receptors. Methods: A new amphiphilic derivative ( Mon Y-BN) containing the BN(7–14) peptide, DTPA (diethylenetriaminepentaacetate) chelating agent, hydrophobic moiety with two C 18 alkyl chains,...
Abstract Background Cow's milk allergy is common in infancy, and total avoidance of this food the only effective approach. In alternative, oral immunotherapy has been proposed to achieve tolerance. Once desensitization achieved, daily intake recommended maintain it, but may be impractical for children/parents. We assessed whether a twice weekly maintenance regimen effective. Methods Children who were successfully desensitized with randomized two regimens 1 year: group A had eat 150–200 ml...
Aim of this commentary is to summarize the salient literature news on relationships between autoimmune thyroid diseases (ATDs) and either Down syndrome (DS) or Turner (TS).According reports both Hashimoto's thyroiditis (HT) Graves' disease (GD) are more frequent in children with DS TS than those without these chromosomopathies.An up-regulation proinflammatory cytokines might be responsible for enhanced susceptibility ATDs, whereas a dysregulation immune system may favor development ATDs...
To analyze the factors that might allow an early discrimination between permanent (P) and transient (T) congenital hypothyroidism (CH).Clinical, biochemical imaging data of 64 children with eutopic gland, who were positively screened treated for CH during period 1998-2011, retrospectively analyzed.During a 3-year treatment period, mean doses <smlcap>L</smlcap>-thyroxine (L-T4) per kilogram body weight at various times significantly lower in 46 T than remaining 18 P CH. No patients had...
Multi-drug-resistant tuberculosis (TB) is a major public health problem, concerning about half million cases each year. Patients hardly adhere to the current strict treatment consisting of more than 10 000 tablets over 2-year period. There clear need for efficient and better formulated medications. We have previously shown that nanoparticles made cross-linked poly-β-cyclodextrins (pβCD) are vehicles pulmonary delivery powerful combinations anti-TB drugs. Here, we report in addition being...