A5042057361- Sexual function and dysfunction studies
- Hormonal and reproductive studies
- Sperm and Testicular Function
- Sexual Differentiation and Disorders
- Urinary Bladder and Prostate Research
- Reproductive Health and Technologies
- Sexuality, Behavior, and Technology
- Genital Health and Disease
- Reproductive Biology and Fertility
- Urologic and reproductive health conditions
- Pelvic floor disorders treatments
- Urological Disorders and Treatments
- Ovarian function and disorders
- Diabetes Management and Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Prostate Cancer Diagnosis and Treatment
- Adolescent Sexual and Reproductive Health
- Reproductive Health and Contraception
- Prostate Cancer Treatment and Research
- Estrogen and related hormone effects
- Hypothalamic control of reproductive hormones
- Eating Disorders and Behaviors
- Diabetes and associated disorders
- Pharmacology and Obesity Treatment
- Pancreatic function and diabetes
Vita-Salute San Raffaele University
2018-2025
IRCCS Ospedale San Raffaele
2018-2025
Institute of Experimental Endocrinology of the Slovak Academy of Sciences
2018-2025
University Foundation
2025
University of Miami
2023-2024
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2022-2024
Radiotelevisione Italiana (Italy)
2020-2023
University College London
2019-2023
University College London Hospitals NHS Foundation Trust
2020-2023
Ospedale di Circolo e Fondazione Macchi
2022
Does the presence of human papillomavirus (HPV) in semen impact seminal parameters and sperm DNA quality white European men seeking medical help for primary couple’s infertility? HPV infections involving high-risk (HR) genotypes are associated with impaired progressive motility fragmentation (SDF) values. is commonly present samples. However, whether actually SDF values have yet to be elucidated. In this cross-sectional study, complete demographic, clinical laboratory data from 729 infertile...
OBJECTIVE To investigate glucose metrics and identify potential predictors of the achievement glycemic outcomes in children adolescents during their first 12 months MiniMed 780G use. RESEARCH DESIGN AND METHODS This multicenter, longitudinal, real-world study recruited 368 with type 1 diabetes (T1D) starting SmartGuard technology between June 2020 2022. Ambulatory profile data were collected a 15-day run-in period (baseline), 2 weeks after automatic mode activation, every 3 months. The...
The association between male infertility and health status has yet to be unraveled. Here, by combining multiparameter phenotyping scRNA-seq, we delineate the immune of infertile men both at semen systemic levels. We first observe that young have a pro-inflammatory milieu with increased frequency myeloid cells inflammatory mediators in seminal fluid peripheral blood, which are alterations typically observed healthy elderly men. Transcriptomic profiling confirms upregulation genes associated...
Male patients with COVID-19 have been found reduced serum total testosterone (tT) levels and more severe clinical outcomes.To assess the probability of recovering eugonadal tT during a minimum 12-month timespan in cohort men who followed over time after recovery from laboratory-confirmed COVID-19.Demographic, hormonal values were collected for overall cohort. Hypogonadism was defined as ≤9.2 nmol/l. The Charlson Comorbidity Index used to score health-significant comorbidities. Descriptive...
Testicular volume (TV) is considered a good clinical marker of hormonal and spermatogenic function. Accurate reference values for TV measures in infertile fertile men are lacking. We aimed to assess references white-European controls. analyzed laboratory data from 1940 (95.0%) 102 (5.0%) Groups were matched by age using propensity score weighting. was assessed Prader orchidometer (PO). Circulating hormones semen parameters investigated every male. Descriptive statistics, Spearman's...
Erectile dysfunction aetiology has been historically identified as organic, psychogenic and mixed.To stratify compare a cohort of patients seeking medical help for erectile the first time according to newly proposed binary classification European Association Urology guidelines: 'primary organic' versus psychogenic'.Complete data from 2009 consecutive presenting were analysed. All completed International Index Function at baseline. According presence dysfunction-related risk factors indexed...
In 2021, the World Health Organization (WHO) has provided latest update on processing and evaluating semen analysis.To assess (i) rate of discordance in parameters categorization across three different WHO reference values (namely WHO21, 2010 1999) (ii) clinical differences among discordant analyses from a cohort primary infertile men.Data 788 men were analyzed. Semen interpreted based WHO10, WHO99 criteria. Pregnancy outcomes with assisted reproductive techniques (ART) available for 110...
Trends of male factor causes couples' infertility over time have been poorly investigated.We investigated trends in the pure (MFI) throughout last 10 years a tertiary-referral academic andrology center.Baseline characteristics at first presentation from cohort 1647 consecutive patients belonging to primary infertile couples between 2008 and 2018 comprehensively collected time. Seven major were identified: varicocoele; history cryptorchidism; hypogonadism (primary secondary); obstructive...
Aim/Hypothesis To compare the frequency of diabetic ketoacidosis (DKA) at diagnosis type 1 diabetes in Italy during COVID-19 pandemic 2020 with DKA 2017-2019. Methods Forty-seven pediatric centers caring for >90% young people recruited 4,237 newly diagnosed children between 2017 and a longitudinal study. Four subperiods were defined based on government-imposed containment measures COVID-19, frequencies severe compared same periods Results Overall, increased from 35.7% (95%CI,...
we aimed to investigate the relationship between tyg index and both semen hormonal characteristics in a cohort of primary infertile men. Summary answer: almost one two men presented with triglycerides/glucose (tyg) suggestive insulin resistance (ir). overall, patients ir showed worse clinical, hormonal, parameters. What is already known: male factor infertility (MFI) often associated metabolic disorders such as diabetes mellitus syndrome, where (IR) plays relevant pathological role....
Overall, male factor infertility (MFI) accounts for up to 50% of etiologies couple's infertility, with almost 30% MFI cases being idiopathic in nature. Idiopathic does not support a tailored treatment work-up clinical practice. To investigate rates and characteristics men presenting versus unexplained primary as compared same-ethnicity, age-comparable fertile men.Demographic, laboratory data from 3,098 infertile consecutively evaluated were analyzed those 103 controls. (IMI) was defined...
Recurrent pregnancy loss and unexplained infertility are the current indications to test sperm DNA fragmentation according European Association of Urology Guidelines on sexual reproductive health.To identify a novel better performing model diagnose primary infertile men presenting with altered outline its predictive ability in respect Guidelines' recommendations.Data from latest 515 consecutive as for World Health Organization criteria were analyzed. Semen analysis, (according chromatin...
Abstract Background Existing literature does not provide accurate epidemiological data regarding the true prevalence of men with non‐obstructive azoospermia (NOA) who would be eligible for hormonal optimization therapy, according to specific pre‐treatment criteria. Objectives To investigate characteristics those NOA qualify medical therapy prior any SR procedure in a large multi‐centric cross‐sectional study. Materials and methods Complete from 1644 patients seeking help primary infertility...
Daily (once a day [OaD]) tadalafil intake is valuable option for men favoring spontaneous over scheduled sexual intercourse.
Abstract Objectives To investigate the distribution of sperm DNA fragmentation (SDF) values and their association with clinical seminal parameters in idiopathic infertile men. Design, Patients, Measurements Data from 3224 primary men (belonging to couples having failed conceive a pregnancy within 12 months) who underwent thorough diagnostic work‐up were analysed. A SDF value ≥ 30% (according Sperm Chromatin Structure Assay) was considered pathologic. We excluded: (1) genetic abnormalities;...