A5027649273- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Diet, Metabolism, and Disease
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiovascular Health and Disease Prevention
- Cystic Fibrosis Research Advances
- Retinal Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Obesity and Health Practices
- Primary Care and Health Outcomes
- Health and Lifestyle Studies
- Diabetes Management and Education
- Eating Disorders and Behaviors
- Liver Disease Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Ocular Surface and Contact Lens
- Fibroblast Growth Factor Research
- Kruppel-like factors research
- Bone fractures and treatments
University of Verona
2015-2025
Azienda Ospedaliera Universitaria Integrata Verona
2021-2025
Medico
2017
Institute of Oncology Research
2010
OBJECTIVE We evaluated the safety and efficacy of day-and-night fully closed-loop insulin therapy using faster (Faster-CL) compared with standard aspart (Standard-CL) in young adults type 1 diabetes. RESEARCH DESIGN AND METHODS In a double-blind, randomized, crossover trial, 20 participants diabetes on pump (11 females, aged 21.3 ± 2.3 years, HbA1c 7.5 0.5% [58.5 5.5 mmol/mol]) underwent two 27-h inpatient periods unannounced afternoon moderate-vigorous exercise unannounced/uncovered meals....
Introduction. To evaluate time in tight range (TITR) 70-140 mg/dL (3.9- 7.8 mmol/L), its correlation with standard continuous glucose monitoring (CGM) metrics and the clinical variables that possibly have a substantial impact on value, large cohort of pediatric subjects using different treatment strategies. Material methods. A total 854 children adolescents type 1 diabetes were consecutively recruited this real-world, dual-center, cross-sectional study. Participants categorized into four...
Background: The aim of this multicenter observational real-world study was to investigate glycemic outcomes in children and adolescents with type 1 diabetes over the first 6-month use MiniMed™ 780G. secondary objective evaluate demographic clinical factors that may be significantly associated achievement therapeutic goals. Methods: Demographic, anamnestic, data participants were collected at time enrollment. Data on ambulatory glucose profile acquired 3 6 months after activating automatic...
Glycemia risk index (GRI) is a novel composite metric for the evaluation of safety glycemic management and control. The aim this study was to evaluate GRI its correlations with continuous glucose monitoring (CGM) metrics by analyzing real-life CGM data in 1067 children/adolescents type 1 diabetes (T1D) using four different treatment strategies (intermittently scanned [isCGM]-multiple daily injections [MDIs]; real-time CGM-MDIs; rtCGM-insulin pump; hybrid closed-loop [HCL] therapy)....
OBJECTIVE To investigate glucose metrics and identify potential predictors of the achievement glycemic outcomes in children adolescents during their first 12 months MiniMed 780G use. RESEARCH DESIGN AND METHODS This multicenter, longitudinal, real-world study recruited 368 with type 1 diabetes (T1D) starting SmartGuard technology between June 2020 2022. Ambulatory profile data were collected a 15-day run-in period (baseline), 2 weeks after automatic mode activation, every 3 months. The...
Hypoglycaemic events are linked to microvascular and macrovascular complications in people with type 1 diabetes. We aimed evaluate the efficacy of glucose sensor [real-time continuous monitoring (RT-CGM)] predictive alarm (PA) reducing time spent below range (%TBR <70 mg/dl) a group adolescents diabetes (AwD).
The study aimed to estimate the prevalence of skin problems in children and adolescents with type 1 diabetes (T1D) using insulin pumps (IPs) and/or continuous glucose monitoring (CGM) our center analyze their association various factors. As part international ISPAD JENIOUS-initiated SKIN-PEDIC project, we interviewed examined patients who visited regional pediatric Opole (Poland) for four weeks regarding use IP CGM presence problems. Body mass index (BMI) glycemic parameters were obtained...
Vitamin D may potentially play a central role in glucose homeostasis and β-cell function (BCF), although studies are not consistent. Aim of our study was to test the hypotheses direct relationship between vitamin D, insulin sensitivity (IS) BCF overweight obese non-diabetic children.Cross-sectional carried out at Childhood Obesity Outpatient Clinic, University Hospital Verona. One hundred twenty-two Caucasian children (age: 12.8 ± 0.2 years) were enrolled. Exclusion criteria: genetic or...
To date, no consistent data are available on the possible impact of CFTR modulators glucose metabolism. The aim this study was to test hypothesis that treatment with is associated an improvement in key direct determinants regulation children and young adults affected by Cystic Fibrosis (CF).In study, 21 CF patients aged 10-25 underwent oral tolerance (OGTT) before after 12-18 months Lumacaftor/Ivacaftor or Elexacaftor-Ivacaftor-Tezacaftor. β-cell function (i.e., first second phase insulin...
We aimed to explore the knowledge, attitude, and management of neonatal diabetes mellitus (NDM) among members International Society for Pediatric Adolescent Diabetes (ISPAD). Members society were invited complete an online questionnaire posted on ISPAD website. received 108 responses from 45 different countries. Of these, 103 involved in NDM management. 87.9% participants would start insulin at diagnosis, 11% prefer sulfonylurea (SU); 54.6% with pump, 80.6% use continuous glucose monitoring....
A factory-calibrated sensor for intermittently scanned continuous glucose monitoring (isCGM) is accurate and safe in children with type 1 diabetes (T1D). Data on isCGM effectiveness as a replacement self-monitoring of blood (SMBG) this population scarce.The aim study was to evaluate the non-adjunctive use T1D during 2 weeks challenging summer-camp setting.In two-arm, parallel, randomized, outpatient clinical trial we enrolled 46 (25 females, mean ± SD: age 11.1 2.6 years, glycated hemoglobin...
Skin reactions due to technological devices pose a significant concern in the management of type 1 diabetes (T1D). This multicentric, comparative cross-sectional study aimed assess psychological impact device-related skin issues on youths with T1D and their parents.
Introduction: Children and adolescents with diabetes are increasingly using technological devices to maintain normoglycemia. However, skin problems associated these becoming a significant issue. This study aimed investigate prevalence of issues in children adoles-cents globally identify important factors problems. Methods: multinational involved 22 pediatric centers. Over 4-week period, pseud anonymized data were collected on devices, includ-ing demographic factors, visual problems, type...
Background: Early detection of type 1 diabetes (T1D) through major islet antibodies screening is gaining momentum as public health strategy, with Italy recently implementing a pilot pediatric program. The transition from research-based to large-scale population initiatives needs automated and standardized assays capable processing extensive sample volumes. This study was hence aimed at evaluating the analytical performance comparability fully-automated chemiluminescence immunoassay (CLIA)...
Over the past two decades, landscape of type 1 diabetes (T1D) management in pediatric populations has undergone a remarkable transformation [...]
Follicular lymphoma (FL) is considered an indolent but incurable disease. It remains to be clarified whether the outcome has changed after recent introduction of novel treatment modalities. We retrospectively analyzed 281 patients with FL treated at Oncology Institute Southern Switzerland from 1979 2007. Three diagnostic eras were considered, according major therapeutic changes: before 1989 (‘alkylating agents era’, n = 73), 1990 1999 (‘aggressive regimens and G-CSF 119), 2000 2007...
No studies have assessed if 2-week of continuous glucose monitoring (CGM) data provide good estimation long-term glycemic control and variability (GV) in pediatric patients with type 1 diabetes (T1D) as adults.Six hundred fifty-four T1D were enrolled 12-weeks CGM data, before HbA1c measurement, collected. Metrics GV incremental sampling periods calculated. The agreement between metrics calculated the full 12-week period was correlation analysis (R2 ), median relative absolute difference...
Background Diet plays a key role in the treatment of type 1 diabetes (T1D). Dietary habits changed rapidly last decades and few data are available on recent dietary changes children adolescents with T1D. Objective To test hypothesis that diet composition 10-year period Methods Two hundred twenty-nine T1D subjects (M/F:121/108) aged 6 to 16 years were recruited: 114 (group A) enrolled 2009, not using CGM and/or CSII, 115 B) 2019. Anthropometric biochemical (HbA1c, lipid profile), diet,...
To assess the prevalence of cardiovascular risk factors (CVRFs) and to identify variables associated with CVRFs in a cohort children adolescents Type 1 Diabetes.2021 subjects, 2-18 year-old, were recruited 17 Italian Pediatric Diabetes Centers. Anthropometric, blood pressure, biochemical (HbA1c, lipid profile, ACR), insulin therapy, physical activity level, smoking family socio-economic status data collected. their distribution analyzed according age binary logistic regression was performed...