A5067351747- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diet and metabolism studies
- Adolescent and Pediatric Healthcare
- Ion Transport and Channel Regulation
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Neonatal Health and Biochemistry
- Childhood Cancer Survivors' Quality of Life
Altonaer Kinderkrankenhaus
2006-2024
KCNJ11 mutations cause permanent neonatal diabetes through pancreatic ATP-sensitive potassium channel activation. 90% of patients successfully transfer from insulin to oral sulfonylureas with excellent initial glycaemic control; however, whether this control is maintained in the long term unclear. Sulfonylurea failure seen about 44% people type 2 after 5 years treatment. Therefore, we did a 10-year multicentre follow-up study large international cohort address key questions relating...
Abstract Background To provide estimates of the nationwide prevalence type 1 diabetes (T1D) and 2 (T2D) in individuals younger than 20 years age Germany from 2002 to 2020 identify trends. Methods Data were obtained electronic health record “Diabetes Prospective Follow‐up Registry (DPV)” specific care. Prevalence was estimated based on prevalent cases at end each year for 2002, 2008, 2014, per 100 000 persons assuming a Poisson distribution directly age‐ and/or sex‐standardized population...
Abstract Aim To assess effects of the SARS-CoV2 pandemic on metabolic control in youth with type 1 diabetes (T1D) Germany a population-based analysis. Methods Data from 33,372 pediatric T1D patients Diabetes Prospective Follow-up (DPV) registry, face-to-face visits or telemedicine contacts years 2019–2021, were available. Datasets eight time periods between March 15, 2020, and December 31, 2021, according to incidence waves, compared those five periods. Parameters assessed adjustment for...
Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycaemia in infancy that leads to unfavourable neurological outcome if not treated adequately. In patients with severe diffuse CHI it remains under discussion whether pancreatic surgery should be performed or intensive medical treatment acceptance recurrent episodes mild justified. Near-total pancreatectomy associated high rates insulin-dependent diabetes mellitus and exocrine insufficiency. Little known about...
<p dir="ltr">Objective This study aims at evaluating the effects of early clinical diagnosis type 1 diabetes by comparison parameters and during follow-up in pediatric patients with early, intermediate late diagnosis. Research design methods In a population-based analysis, data 14,292 diagnosed between 2015 2019 were retrieved from DPV registry March 2023. Patients divided into four groups, one diabetic ketoacidosis (DKA) diagnosis, three or based on age-dependent HbA1c terciles....
This study was conducted to evaluate the effects of early clinical diagnosis type 1 diabetes by comparison parameters at and during follow-up in patients with pediatric early, intermediate, late diagnosis.
<p dir="ltr">Objective This study aims at evaluating the effects of early clinical diagnosis type 1 diabetes by comparison parameters and during follow-up in pediatric patients with early, intermediate late diagnosis. Research design methods In a population-based analysis, data 14,292 diagnosed between 2015 2019 were retrieved from DPV registry March 2023. Patients divided into four groups, one diabetic ketoacidosis (DKA) diagnosis, three or based on age-dependent HbA1c terciles....
Fragestellung Umweltepidemiologische Studien zeigen erhöhte Krankenhauseinweisungsraten bei Hitze- und Kälteexposition. Das Auftreten einer diabetischen Ketozidose (DKA) Kindern Jugendlichen mit manifestiertem Typ-1-Diabetes (T1D) wurde in diesem Kontext bislang nicht untersucht. Ziel dieser Analyse war es, einen möglichen Zusammenhang zwischen den Temperatur-Tagesmittelwerten dem DKA T1D zu untersuchen. Methodik: Kinder Jugendliche<21 Jahre (mindestens 6 Monate Diagnose, Diabetesdauer ≥ 1...
Neonatal diabetes is a condition with an incidence of 1:500.000 newborns. Heterozygous activating mutations in KCNJ11, which encodes the Kir 6.2 subunit pancreatic ATP-sensitive potassium channel and hence inhibits insulin secretion, cause 35–60% permanent neonatal diabetes. In about 10% these patients additional neurological abnormalities like muscle weakness, disturbances speech epilepsy occur. As new entity DEND-syndrome (developmental delay-epilepsy-neonatal diabetes) has been described,...
Fragestellung Ziel der Auswertung war die Schätzung Typ-1-Diabetesprävalenz sowie des Prävalenztrends bei Kindern und Jugendlichen (<20 Jahre) basierend auf einem deutschlandweiten Diabetesregister.