A5004814449- Renal Transplantation Outcomes and Treatments
- Hormonal Regulation and Hypertension
- Transplantation: Methods and Outcomes
- Blood Pressure and Hypertension Studies
- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- Renal and Vascular Pathologies
- Cardiac Imaging and Diagnostics
- Hemodynamic Monitoring and Therapy
- Central Venous Catheters and Hemodialysis
- Pharmaceutical Practices and Patient Outcomes
- Dialysis and Renal Disease Management
- Herpesvirus Infections and Treatments
- Cancer Genomics and Diagnostics
- Pneumocystis jirovecii pneumonia detection and treatment
- Advanced X-ray and CT Imaging
- Infectious Encephalopathies and Encephalitis
- Complement system in diseases
- Pharmacological Effects and Toxicity Studies
- Polyomavirus and related diseases
- Renal Diseases and Glomerulopathies
- Antibiotics Pharmacokinetics and Efficacy
- Sodium Intake and Health
- Peripheral Neuropathies and Disorders
- Medical Imaging and Pathology Studies
Intermountain Medical Center
2016-2024
Intermountain Healthcare
2024
Richard L. Roudebush VA Medical Center
2012
Indiana University – Purdue University Indianapolis
2012
Dr. Georges-L.-Dumont University Hospital Centre
2008-2011
Maimonides Medical Center
2010
Donor-derived cell-free DNA (dd-cfDNA) is an emerging noninvasive biomarker that has the potential to detect allograft injury. The capacity of dd-cfDNA kidney rejection and its added clinical value beyond standard care patient monitoring unclear. We enrolled 2,882 recipients from 14 transplantation centers in Europe United States observational population-based study. primary analysis included 1,134 patients. levels strongly correlated with rejection, including antibody-mediated (P < 0.0001),...
The use of routine monitoring donor-derived cell-free DNA (dd-cfDNA) after kidney transplant may allow clinicians to identify subclinical allograft injury and intervene prior development clinically evident graft injury. To evaluate this, data from 1092 recipients monitored for dd-cfDNA over a three-year period was analyzed assess the association with histologic evidence rejection. Elevation (0.5% or more) significantly correlated clinical values 0.5% more were associated nearly three-fold...
Standard-of-care biomarkers for renal allograft rejection are lagging indicators, signaling existing organ injury. This precludes early intervention, when immunological cascades leading to most susceptible. Donor-derived cell-free DNA (dd-cfDNA) shows promise as an indicator of rejection, allowing earlier and possibly more effective treatment. analysis was designed assess this using real-world dd-cfDNA testing evidence.
Prophylaxis against Pneumocystis jirovecii pneumonia (PCP) is recommended for at least 4-12 months after solid organ transplant. In our center, renal transplant recipients receive only 1 month of post-transplant trimethoprim-sulfamethoxazole, which also may provide limited protection Nocardia. We identified 4 PCP cases and Nocardia in 1352 patients receiving renal-pancreas from 2003 to 2009 the University Michigan Health System. Two were <1 year transplant, 2 >1 (gross attack rate 4/1352,...
The longitudinal time-course of dd-cfDNA after kidney transplant (KTx) is not well-described. cut off values in KTx derive from biopsy-coupled single measurements. Meaningful interpretation necessitates understanding of: (1) time variance levels post-KTx, (2) factors determining biologic variability, and (3) relationship to donor recipient characteristics. We hypothesized that an the aforementioned would better inform clinical decision-making using dd-cfDNA.One hundred twenty five patients...
Summary Background and objectives Hypervolemia is a major cause of morbidity, in part because the lack well characterized diagnostic tests. The hypothesis was that relative plasma volume (RPV) slopes are influenced by ultrafiltration rate, directly associate with improvement arterial oxygen saturation, reproducible. Design, setting, participants, & measurements RPV were measured on three consecutive hemodialysis sessions. Various relationships tested using mixed models. Reproducibility...
Abstract Introduction Living donor kidney evaluation has substantial time variations with significant intercenter variation. One‐day shown to be clinically efficient and improve transplant rates. However, patients’ perception of 1‐day is unknown. We hypothesized that 1 day LKD will patient satisfaction living donation Methods All interested LD candidates from April 2018 May 2020 were enrolled in the study. Non‐directed donors, donors greater than 60 years old, recipients more three underwent...
Background: In patients with end-stage kidney disease, assessment of cardiovascular (CV) risk is difficult due to a lack analytical decision tools guide care. The Intermountain score (IMRS) well-validated sex-specific prediction tool calculated from weightings age and components the complete blood count basic metabolic profile that was originally derived predict mortality. IMRS also predicts major CV events. This study evaluated association adverse events (MACE) in listed for renal...
Herpes simplex virus is the most common cause of sporadic encephalitis. However, diagnosis can be challenging in atypical cases. Without prompt treatment, morbidity and mortality high. We report a case herpes encephalitis (HSE) 23-year-old man presenting with an intracerebral hematoma. After anatomical etiology was ruled out, acyclovir started. Later, polymerase chain reaction cerebrospinal fluid positive for virus-1. review previously reported cases HSE ICH, as well other presentations HSE.