A5091069264- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Organ Donation and Transplantation
- Complement system in diseases
- Cytomegalovirus and herpesvirus research
- Neurological Complications and Syndromes
- T-cell and B-cell Immunology
- Blood groups and transfusion
- Pregnancy and Medication Impact
- Polyomavirus and related diseases
- Cancer Genomics and Diagnostics
- Liver Disease and Transplantation
- Mycobacterium research and diagnosis
- Organ and Tissue Transplantation Research
- Pediatric Urology and Nephrology Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Chronic Kidney Disease and Diabetes
- Cardiac Structural Anomalies and Repair
- Dialysis and Renal Disease Management
- Immune Cell Function and Interaction
- Vasculitis and related conditions
- Viral Infections and Immunology Research
Hôpital Saint-Louis
2016-2025
Université Paris Cité
2015-2024
Inserm
2015-2024
Assistance Publique – Hôpitaux de Paris
2015-2024
Paris Cardiovascular Research Center
2011-2024
Translational Research in Oncology
2014-2023
Hôpital Necker-Enfants Malades
2015-2023
RELX Group (United States)
2018-2022
Ecotaxie, Microenvironnement et développement lymphocytaire
2014-2020
Weatherford College
2019
The kidney sessions of the 2017 Banff Conference focused on 2 areas: clinical implications inflammation in areas interstitial fibrosis and tubular atrophy (i-IFTA) its relationship to T cell-mediated rejection (TCMR), continued evolution molecular diagnostics, particularly diagnosis antibody-mediated (ABMR). In confirmation previous studies, it was independently demonstrated by groups that i-IFTA is associated with reduced graft survival. Furthermore, these presented i-IFTA, when involving...
Anti-HLA antibodies hamper successful transplantation, and activation of the complement cascade is involved in antibody-mediated rejection. We investigated whether complement-binding capacity anti-HLA plays a role kidney-allograft failure.We enrolled patients who received kidney allografts at two transplantation centers Paris between January 1, 2005, 2011, population-based study. Patients were screened for presence circulating donor-specific their capacity. Graft injury phenotype time to...
The clinical importance of preexisting HLA antibodies at the time transplantation, identified by contemporary techniques, is not well understood. We conducted an observational study analyzing association between donor-specific (HLA-DSA) and incidence acute antibody-mediated rejection (AMR) survival patients grafts among 402 consecutive deceased-donor kidney transplant recipients. detected HLA-DSA using Luminex single-antigen assays on peak reactive current sera. All had a negative...
The XV. Banff conference for allograft pathology was held in conjunction with the annual meeting of American Society Histocompatibility and Immunogenetics Pittsburgh, PA (USA) focused on refining recent updates to classification, advances from working groups, standardization molecular diagnostics. This report kidney transplant details clarifications refinements criteria chronic active (CA) T cell–mediated rejection (TCMR), borderline, antibody-mediated (ABMR). main focus sessions how address...
The XIII Banff meeting, held in conjunction the Canadian Society of Transplantation Vancouver, Canada, reviewed clinical impact updates C4d-negative antibody-mediated rejection (ABMR) from 2013 reports active Working Groups, relationships donor-specific antibody tests (anti-HLA and non-HLA) with transplant histopathology, questions molecular diagnostics. use transcriptome gene sets, their resultant diagnostic classifiers, or common key genes to supplement diagnosis classification requires...
Kidney allograft rejection can occur in clinically stable patients, but long-term significance is unknown. We determined whether early recognition of subclinical has consequences for kidney survival an observational prospective cohort study 1307 consecutive nonselected patients who underwent ABO-compatible, complement-dependent cytotoxicity-negative crossmatch transplantation Paris (2000-2010). Participants screening biopsies at 1 year post-transplant, with concurrent evaluations graft...
Antibodies may have different pathogenicities according to IgG subclass. We investigated the association between subclasses of circulating anti-human HLA antibodies and antibody-mediated kidney allograft injury. Among 635 consecutive transplantations performed 2008 2010, we enrolled 125 patients with donor-specific (DSA) detected in first year post-transplant. assessed DSA characteristics, including specificity, class mean fluorescence intensity (MFI), C1q-binding, subclass, graft injury...
Abstract Objective To develop and validate an integrative system to predict long term kidney allograft failure. Design International cohort study. Setting Three cohorts including transplant recipients from 10 academic medical centres Europe the United States. Participants Derivation cohort: 4000 consecutive prospectively recruited in four French between 2005 2014. Validation cohorts: 2129 three 1428 North America, 2002 Additional validation randomised controlled trials ( NCT01079143 ,...
Antibody-mediated rejection (ABMR) can occur in patients with preexisting anti-HLA donor-specific antibodies (DSA) or who develop de novo DSA. However, how these processes compare terms of allograft injury and outcome has not been addressed. From a cohort 771 kidney biopsy specimens from two North American five European centers, we performed systematic assessment clinical biologic parameters, histopathology, circulating DSA, gene expression for all ABMR ( n =205). Overall, 103 (50%) had DSA...
Significance Statement Although studies have found coronavirus disease 2019 (COVID-19) to be associated with high morbidity and mortality among kidney transplant recipients, risk factors for COVID-19 patients remain poorly defined. In this prospective cohort study in France, the authors enrolled 1216 patients, 66 (5%) of whom were diagnosed COVID-19. The rate overall population was 1% 24% COVID-19–positive patients. Factors that independently included non-White race comorbidities, including...
Approximately 3500 donated kidneys are discarded in the United States each year, drawing concern from Medicare and advocacy groups.To estimate effects of more aggressive allograft acceptance practices on donor pool survival for population US wait-listed kidney transplant candidates.A nationwide study using validated registries France comprising comprehensive cohorts deceased donors with organs offered to centers between January 1, 2004, December 31, 2014. Data were analyzed September 2018,...
The XVI-th Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from 19th-23rd September 2022, as a joint meeting with the Canadian Society of Transplantation. To mark 30th anniversary first Classification, pre-meeting discussions were on past, present, and future Classification. This report is summary highlights that most important terms their effect including around microvascular inflammation biopsy-based transcript analysis diagnosis. In post-meeting survey, agreement...
Donor-derived cell-free DNA (dd-cfDNA) is an emerging noninvasive biomarker that has the potential to detect allograft injury. The capacity of dd-cfDNA kidney rejection and its added clinical value beyond standard care patient monitoring unclear. We enrolled 2,882 recipients from 14 transplantation centers in Europe United States observational population-based study. primary analysis included 1,134 patients. levels strongly correlated with rejection, including antibody-mediated (P < 0.0001),...
Abstract In kidney transplantation, day-zero biopsies are used to assess organ quality and discriminate between donor-inherited lesions those acquired post-transplantation. However, many centers do not perform such since they invasive, costly may delay the transplant procedure. We aim generate a non-invasive virtual biopsy system using routinely collected donor parameters. Using 14,032 from 17 international centers, we develop system. 11 basic parameters predict four Banff lesions:...
This study analyzes the influence of preformed DSA, identified by HLA-specific ELISA assays, on graft survival and evaluates incidence antibody-mediated rejection (AMR) in patients with without pregraft desensitization. Kidney at 8 years was significantly worse DSA (n = 43) than those 194)(p 0.03). The AMR is 9-fold higher (p < 0.001) their non-DSA 0.005). prevalence for detected historic serum 32.3% nondesensitized 41.7% desensitized patients. risk more elevated strongly positive (score...