A5055171681- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Transplantation: Methods and Outcomes
- Chronic Kidney Disease and Diabetes
- Complement system in diseases
- Organ Transplantation Techniques and Outcomes
- Immune Cell Function and Interaction
- Acute Kidney Injury Research
- Renal and Vascular Pathologies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- COVID-19 and healthcare impacts
- Tuberculosis Research and Epidemiology
- Vasculitis and related conditions
- Dialysis and Renal Disease Management
- Autoimmune Bullous Skin Diseases
- Mycobacterium research and diagnosis
- COVID-19 Clinical Research Studies
- Advanced Breast Cancer Therapies
- Acne and Rosacea Treatments and Effects
- Polyomavirus and related diseases
- Pregnancy and Medication Impact
- Drug-Induced Ocular Toxicity
- Organ and Tissue Transplantation Research
Hôpital Saint-Louis
2021-2024
Assistance Publique – Hôpitaux de Paris
2017-2024
Université Paris Cité
2015-2024
Inserm
2017-2024
Sorbonne Université
2015-2024
Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée
2022-2024
Paris Cardiovascular Research Center
2021-2023
Translational Research in Oncology
2017-2023
University of Pittsburgh
2023
RELX Group (United States)
2022
Significance Statement Although studies have found coronavirus disease 2019 (COVID-19) to be associated with high morbidity and mortality among kidney transplant recipients, risk factors for COVID-19 patients remain poorly defined. In this prospective cohort study in France, the authors enrolled 1216 patients, 66 (5%) of whom were diagnosed COVID-19. The rate overall population was 1% 24% COVID-19–positive patients. Factors that independently included non-White race comorbidities, including...
Abstract Background The COVID-19 pandemic has severely affected health systems and medical research worldwide but its impact on the global publication dynamics non-COVID-19 not been measured. We hypothesized that may have impacted scientific production of research. Methods conducted a comprehensive meta-research studies (original articles, letters case reports) published between 01/01/2019 01/01/2021 in 10 high-impact infectious disease journals (New England Journal Medicine, Lancet,...
Vancomycin is a widely prescribed antibiotic, but the exact nature of vancomycin-associated nephrotoxicity unclear, in particular when considering frequent coadministration aminoglycosides. We describe here initial case 56-year-old woman with normal renal function developing unexplained ARF without hypovolemia after administration vancomycin Studying patient’s biopsy specimen, we ascertained that obstructive tubular casts composed noncrystal nanospheric aggregates entangled uromodulin...
Inflammation in fibrosis areas (i-IF/TA) of kidney allografts is associated with allograft loss; however, its diagnostic significance remains to be determined. We investigated the clinicohistologic phenotype and determinants i-IF/TA a prospective cohort 1539 recipients undergoing evaluation tubulitis atrophic tubules (t-IF/TA) on protocol biopsies performed at 1 year posttransplantation. considered donor, recipient, transplant characteristics, immunosuppression, histological diagnoses 2260...
The recent recognition of complex and chronic phenotypes T cell-mediated rejection (TCMR) has fostered the need to better evaluate response acute TCMR-a condition previously considered lack relevant consequences for allograft survival-to standard care. In a prospective cohort kidney recipients (n = 256) with biopsy-proven TCMR receiving corticosteroids, we investigated clinical, histological, immunological at time diagnosis 3 months posttreatment. Independent posttreatment determinants loss...
Although antibody-mediated rejection (ABMR) has been long recognized as a leading cause of allograft failure after kidney transplantation, the cellular and molecular processes underlying induction deleterious donor-specific antibody (DSA) responses remain poorly understood.Using high-dimensional flow cytometry, in vitro assays, RNA sequencing, we concomitantly investigated role T follicular helper (TFH) cells B during ABMR 105 transplant recipients.There were 54 patients without DSAs; those...
Alloimmune responses driven by donor-specific antibodies (DSAs) can lead to antibody-mediated rejection (ABMR) in organ transplantation. Yet, the cellular states underlying alloreactive B cell and molecular components controlling them remain unclear. Using high-dimensional profiling of cells a cohort 96 kidney transplant recipients, we identified expanded numbers CD27+CD21– activated memory (AM) that expressed transcription factor T-bet patients who developed DSAs progressed ABMR. Notably,...
IntroductionDuring glomerular diseases, podocyte-specific pathways can modulate the intensity of histological disease and prognosis. The therapeutic targeting these could thus improve management prognosis kidney diseases. Janus Kinase/ Signal Transducer Activator Transcription (JAK/STAT) pathway, classically described in immune cells, has been recently detailed intrinsic cells.MethodsWe describe STAT5 expression human biopsies from patients with focal segmental glomerulosclerosis (FSGS)...
Graft microvasculature is a major target of donor-specific antibodies (DSA) and endothelial damage direct evidence antibody-mediated rejection (ABMR). Using immunohistochemistry, we analyzed the expression three microvascular activation markers (fascin, vimentin, hsp47), suggestive endothelial-to-mesenchymal transition (EndMT) in 351 graft biopsies from 248 kidney recipients, with concomitant screening circulating antihuman leukocyte antigen (HLA) DSA at time biopsy. The factors associated...
Chronic Epstein-Barr virus (EBV) infection after pediatric organ transplantation (Tx) accounts for significant morbidity and mortality. The risk of complications, such as posttransplant lymphoproliferative disorders, in high viral load (HVL) carriers is the highest heart Tx recipients. However, immunologic signatures a have been insufficiently defined. Here, we assessed phenotypic, functional, transcriptomic profiles peripheral blood CD8+/CD4+ T cells, including EBV-specific 77 heart,...
Acute tubular necrosis (ATN), a frequent histopathological feature in the early post-renal transplant biopsy, affects long-term graft function. Appropriate markers to identify patients at risk of no or incomplete recovery after delayed function are lacking. In this study, we first included 41 renal whose biopsy for cause during month transplantation showed ATN lesions. Using partial microvasculature endothelial (fascin, vimentin) and epithelial (vimentin) mesenchymal transition markers,...