A5075466867- Pediatric Urology and Nephrology Studies
- Genetic and Kidney Cyst Diseases
- Renal and related cancers
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- MRI in cancer diagnosis
- Viral Infections and Immunology Research
University of Pittsburgh
2019-2023
Significance Statement Accurate prediction of risk for disease progression is crucial clinical management autosomal dominant polycystic kidney (ADPKD). The Mayo imaging classification ADPKD uses height-adjusted total volume (htTKV) and age to identify patients at highest risk. Because the current applies only with typical diffuse cystic (class 1) poorly predicts eGFR decline remaining 5%–10% atypical morphology 2), imaging-based modeling remains unresolved. authors report an expanded model...
Chronic Epstein-Barr virus (EBV) infection after pediatric organ transplantation (Tx) accounts for significant morbidity and mortality. The risk of complications, such as posttransplant lymphoproliferative disorders, in high viral load (HVL) carriers is the highest heart Tx recipients. However, immunologic signatures a have been insufficiently defined. Here, we assessed phenotypic, functional, transcriptomic profiles peripheral blood CD8+/CD4+ T cells, including EBV-specific 77 heart,...