A5046048183- Renal Transplantation Outcomes and Treatments
- Chronic Kidney Disease and Diabetes
- COVID-19 Clinical Research Studies
- Renal and Vascular Pathologies
- Parathyroid Disorders and Treatments
- Organ Donation and Transplantation
- Dialysis and Renal Disease Management
- Muscle and Compartmental Disorders
- Renal Diseases and Glomerulopathies
- Medical Imaging and Pathology Studies
- Electrolyte and hormonal disorders
- Bone health and osteoporosis research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Transplantation: Methods and Outcomes
- Diabetes Treatment and Management
- Pharmacological Effects and Toxicity Studies
- Vitamin D Research Studies
- Organ Transplantation Techniques and Outcomes
- Blood Pressure and Hypertension Studies
- Bone health and treatments
- Acute Kidney Injury Research
- Long-Term Effects of COVID-19
- Pancreatitis Pathology and Treatment
- Neurological Complications and Syndromes
University of Liège
2015-2025
Centre Hospitalier Universitaire de Liège
2014-2024
Paris Cardiovascular Research Center
2023
Université Paris Cité
2019-2023
Inserm
2018-2023
Translational Research in Oncology
2018
Abstract In kidney transplantation, day-zero biopsies are used to assess organ quality and discriminate between donor-inherited lesions those acquired post-transplantation. However, many centers do not perform such since they invasive, costly may delay the transplant procedure. We aim generate a non-invasive virtual biopsy system using routinely collected donor parameters. Using 14,032 from 17 international centers, we develop system. 11 basic parameters predict four Banff lesions:...
Background Many kidneys donated for transplant in the United States are discarded because of abnormal histology. Whether histology adds incremental value beyond usual donor attributes assessing allograft quality is unknown. Methods This population-based study included patients who received a deceased kidney that had been biopsied before implantation according to prespecified protocol France and Belgium, where preimplantation biopsy findings generally not used decision making allocation...
Various symptoms and considerable organ dysfunction persist following infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Uncertainty remains about the potential mid- long-term health sequelae. This prospective study of patients hospitalized coronavirus disease 2019 (COVID-19) in Liège University Hospital, Belgium aimed to determine persistent consequences COVID-19.Patients admitted Hospital moderate-to-severe confirmed COVID-19, discharged between 2 March 1 October...
Aim For drug dosing adaptation, the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend using estimated glomerular filtration rate (eGFR) by Chronic Disease Epidemiology Collaboration (CKD‐EPI) equation, after ‘de‐indexation’ body surface area (BSA). In pharmacology, Cockcroft–Gault (CG) equation is still recommended to adapt dosage. context of obesity, adjusted ideal weight (AIBW) sometimes preferred actual (ABW) for CG equation. The aim present study was compare...
Abstract Background Proteinuria has been commonly reported in patients with COVID-19. However, only dipstick tests have frequently used thus far. Here, the quantification and characterization of proteinuria were investigated their association mortality was assessed. Methods This retrospective, observational, single center study included 153 patients, hospitalized COVID-19 between March 28th April 30th, 2020, whom total urinary α 1 -microglobulin (a marker tubular injury) measured....
Obesity is a recognized risk factor for both the development and progression of chronic kidney disease (CKD). Accurate estimation glomerular filtration rate (GFR) thus important in these patients. We tested performances two creatinine-based GFR estimates, Modification Diet Renal Disease (MDRD) Chronic Kidney Epidemiology Collaboration (CKD-EPI) equations, an obese population. Patients with body mass index (BMI) > 30 kg/m2 were included. The reference method measured (mGFR) was 51Cr-EDTA...
Background Kidney damage has been reported in patients with COVID-19. Despite numerous reports about COVID-19–associated nephropathy, the factual presence of SARS-CoV-2 renal parenchyma remains controversial. Methods We consecutively performed 16 immediate (≤3 hours) postmortem biopsies diagnosed samples from five who died sepsis not related to COVID-19 were used as controls. Samples methodically evaluated by three pathologists. Virus detection was all bulk RNA RT-PCR (E and N1/N2 genes),...
Precise determination of circulating parathyroid hormone (PTH) concentration is crucial to diagnose and manage various disease conditions, including the chronic kidney disease–mineral bone disorder. However, lack standardization in PTH assays challenging for clinicians, potentially leading medical errors because different do not provide equivalent results use reference ranges. Here, we aimed evaluate impact recalibrating immunoassays by means a recently developed LC-MS/MS method as...
Sclerostin, a 22-kDa protein secreted by osteocytes, acts as potent inhibitor of osteoblast activity. In chronic kidney disease (CKD), sclerostin is putative driver the bone–vascular axis. However, large discrepancies between assays have been described. We compared four different [Biomedica (BM), TecoMedical (TE), R&D (RD) and MesoScaleDiscovery (MSD)] in an analytical study addressed question whether bioassay choice affects correlation circulating clinical biochemical determinants....
An accurate estimated glomerular filtration rate (eGFR) is essential in drug dosing. This study demonstrates the limitations of indexed (ml/min/1.73 m
Key Points Surgical AVF ligation in KTRs is associated with a significant increase diastolic BP while systolic remains stable. closure leads to an improvement of LV and LA morphology decrease serum NT-proBNP levels. There no effect on kidney allograft function: The eGFR stable over time. Background Kidney transplantation considered as the best replacement therapy, arteriovenous fistula (AVF) preferred vascular access for hemodialysis. systematic functioning transplant recipients (KTRs)...
Subclinical kidney allograft acute rejection (SCR) corresponds to "the unexpected histological evidence of in a stable patient." SCR detection relies on surveillance biopsy. Noninvasive approaches may help avoid biopsy-associated complications. From November 2015 January 2018, we prospectively performed positron emission tomography/computed tomography (PET/CT) after injection F18-fluorodeoxyglucose (18F-FDG) adult transplant recipients with biopsy at ~3 months posttransplantation. The...