A5069934454- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Vitamin D Research Studies
- Sports injuries and prevention
- Cardiovascular Effects of Exercise
- Cardiovascular and exercise physiology
- Exercise and Physiological Responses
- Vitamin C and Antioxidants Research
- Pharmacological Effects and Toxicity Studies
- Periodontal Regeneration and Treatments
- Pesticide Residue Analysis and Safety
- Heart Failure Treatment and Management
- Metabolomics and Mass Spectrometry Studies
- Cardiovascular Function and Risk Factors
- Orthopedic Surgery and Rehabilitation
- Hormonal and reproductive studies
- Bone health and osteoporosis research
- Myofascial pain diagnosis and treatment
- Pharmacological Effects and Assays
- Reproductive Physiology in Livestock
- Diet and metabolism studies
- Cardiac Imaging and Diagnostics
- Adrenal Hormones and Disorders
- Effects and risks of endocrine disrupting chemicals
- Hormonal Regulation and Hypertension
Centre Hospitalier Universitaire de Liège
2016-2025
University of Liège
2016-2025
KU Leuven
2023
AZ Groeninge
2023
Universitair Ziekenhuis Leuven
2023
Antwerp University Hospital
2023
Clinique Saint-Joseph
2015-2022
Institut National de la Recherche Agronomique
2020
CHU Dijon Bourgogne
2020
University of Alabama in Huntsville
2015
Background: A key role of oxidative stress has been highlighted in the pathogenesis COVID-19. However, little said about status (OSS) COVID-19 patients hospitalized intensive care unit (ICU). Material and Methods: Biomarkers systemic OSS included antioxidants (9 assays), trace elements (3 inflammation markers (4 assays) damage to lipids assays). Results: Blood samples were drawn after 9 (7–11) 41 (39–43) days ICU stay, respectively 3 6 patients. Vitamin C, thiol proteins, reduced...
In sports medicine, there is increasing interest in quantifying the elastic properties of skeletal muscle, especially during extreme muscular stimulation, to improve our understanding impact alterations muscle stiffness on resulting pain or injuries, as well mechanisms underlying relationships between these parameters. Our main objective was determine whether real-time shear-wave elastography (SWE) can monitor changes quadriceps elasticity an mountain ultra-marathon, a powerful mechanical...
Abstract P latelet‐rich plasma ( PRP ) contains growth factors involved in the tissular healing process. The aim of study was to determine if an injection could improve sectioned A chilles tendons rats. After surgery, rats received n = 60) or a physiological solution situ. 5, 15, and 30 days, 20 both groups were euthanized 15 collected submitted biomechanical test using cryo‐jaws before performing transcriptomic analyses. Histological biochemical analyses performed on five remaining each...
Abstract The treatment of choice for tendinopathies is eccentric reeducation. Although the clinical results appear favorable, biomechanical changes to tissue are not yet clear. Even if mechanotransduction theory commonly accepted, physiology tendons clearly understood. We aimed better define and histological that affect healthy tendon after concentric training. This study compared effects two methods training (eccentric [E] [C] training) with untrained (U) rats. animals were trained over a...
Osteoarthritis (OA) is associated with a local inflammatory process. Dyslipidemia known to be an underlying cause for the development of OA. Therefore, lipid and levels were quantified ex vivo in blood synovial fluid OA patients (n=29) compared those rheumatoid arthritis (RA) (n=27) or healthy volunteers (HV) (n=35). The role apolipoprotein A-I (ApoA1) was investigated vitro on parameters using human joint cells isolated from cartilage membrane obtained after replacement. Cells stimulated...
Parathyroid hormone (PTH) measurement is important for patients with disorders of calcium metabolism, including those needing bone-turnover monitoring due to chronic kidney disease-mineral bone disorder. There are currently 2 generations PTH immunoassays on the market, both having cross-reactivity issues and lacking standardization. Therefore, we developed an LC-MS/MS higher-order method analysis.
Abstract Commutability is where the measurement response for a reference material (RM) same as an individual patient sample with concentration of analyte measured using two or more systems. Assessment commutability essential when RM used in calibration hierarchy to ensure that clinical measurements are comparable across different procedures and at times. The three new Standard Reference Materials ® (SRMs) determining serum total 25-hydroxyvitamin D [25(OH)D], defined sum 2 [25(OH)D ] 3 ],...
Oxytocin is a 9-amino acid peptide that serves as neuromodulator in the human central nervous system. This implicated regulation of diverse behaviors and plays significant role positive social interaction. Currently, oxytocin levels are measured using immunoassays. However, these methods have several limitations can lead to false results erroneous interpretation. Given remarkably low endogenous level plasma (low ng/L levels), we developed rigorously validated novel highly sensitive LC-MS/MS...
Tendon lesions are among the most frequent musculoskeletal pathologies. Vascular endothelial growth factor (VEGF) is known to regulate angiogenesis. VEGF-111, a biologically active and proteolysis-resistant splice variant of this family, was recently identified. This study aimed at evaluating whether VEGF-111 could have therapeutic interest in tendon Surgical section one Achilles rats performed before local injection either saline or VEGF-111. After 5, 15 30 days, tendons 10 both groups were...
B-type natriuretic peptide (BNP) is often used as a complementary finding in the diagnostic work-up of patients with aortic stenosis (AS). Whether soluble ST2, new biomarker cardiac stretch, associated symptomatic status and outcome asymptomatic AS unknown. sST2 BNP levels were measured 86 (74±13 years; 59 asymptomatic, 69%) (<1.5 cm2) preserved left ventricular ejection fraction who followed-up for 26±16 months. Both NYHA class but (>23 ng/mL, AUC = 0.68, p<0.01) was more accurate to...
Tendon lesions are among the most frequent musculoskeletal pathologies.Vascular endothelial growth factor (VEGF) is known to regulate angiogenesis.VEGF-111, a biologically active and proteolysis-resistant splice variant of this family, was recently identified.This study aimed at evaluating whether VEGF-111 could have therapeutic interest in tendon pathologies.Surgical section one Achilles rats performed before local injection either saline or VEGF-111.After 5, 15 30 days, tendons 10 both...
Abstract Background Simultaneous measurement of 25(OH)D and 24,25(OH)2D is a new tool for predicting vitamin D deficiency allows evaluating CYP24A1 lack function. Interpretation should be performed according to levels ratio, called the metabolite ratio (VMR) has been proposed such purpose. Unfortunately, VMR can expressed in different ways cannot used if concentrations are undetectable. Here, we propose enzyme activity taking into consideration probability that normal population presents...
Vitamin D status is typically assessed by the measurement of 25-hydroxyvitamin (25(OH)D). However, in selected patient groups sole determination 25(OH)D has been proven insufficient for this purpose. The simultaneous additional vitamin metabolites may provide useful information a better evaluation status. Therefore, we developed and validated liquid chromatography tandem mass spectrometry (LC-MS/MS) method 25(OH)D3, 25(OH)D2, 24,25(OH)2D3 additionally 25,26(OH)2D3, which was identified with...