A5081270901- Radiomics and Machine Learning in Medical Imaging
- Nonlinear Photonic Systems
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- HER2/EGFR in Cancer Research
- Mathematical Biology Tumor Growth
- Monoclonal and Polyclonal Antibodies Research
- Medical Imaging Techniques and Applications
- Advanced Fiber Laser Technologies
- Medical Imaging and Pathology Studies
- Peptidase Inhibition and Analysis
- Radiopharmaceutical Chemistry and Applications
- Glioma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Nanoparticle-Based Drug Delivery
- Machine Learning in Materials Science
- Colorectal Cancer Treatments and Studies
- Nonlinear Dynamics and Pattern Formation
- Optical Coherence Tomography Applications
- Optical Network Technologies
- Inhalation and Respiratory Drug Delivery
- Prostate Cancer Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Galectins and Cancer Biology
Université Libre de Bruxelles
2014-2023
Erasmus Hospital
2009-2023
VIB-UAntwerp Center for Molecular Neurology
2013-2017
Institute of Immunology
2013
Concerted alteration of immune and metabolic homeostasis underlies several inflammation-related pathologies, ranging from syndrome to infectious diseases. Here, we explored the coordination nucleic acid-dependent inflammatory responses homeostasis. We reveal that STING (stimulator interferon genes) protein regulates through inhibition fatty acid desaturase 2 (FADS2) rate-limiting enzyme in polyunsaturated (PUFA) desaturation. ablation agonist-mediated degradation increased FADS2-associated...
Through a detailed spectral analysis of the propagation square-shaped laser pulses in optical fibers, we provide experimental demonstration Fermi-Pasta-Ulam recurrence phenomenon modulationally unstable waves ruled by nonlinear Schrödinger equation.
Interleukin (IL) 12 and IL23 are two related heterodimeric cytokines produced by antigen-presenting cells. The balance between these plays a crucial role in the control of Th1/Th17 responses autoimmune inflammation. Most studies focused on their transcriptional regulation. Herein, we explored adenine uridine–rich element (ARE)–binding protein tristetraprolin (TTP) influencing mRNA stability IL12p35, IL12/23p40, IL23p19 subunits. LPS-stimulated bone marrow–derived dendritic cells (BMDCs) from...
Colorectal cancer (CRC) cells are traditionally considered unresponsive to TGFβ due mutations in the receptors and/or downstream signaling molecules. influences CRC only indirectly via stromal cells, such as cancer-associated fibroblasts. However, cell ability directly respond currently remains unexplored. This represents a missed opportunity for diagnostic and therapeutic interventions. Methods: We examined whether from primary liver metastases by inducing TGFβ-induced protein ig-h3 (TGFBI)...
Abstract The thyroid gland captures iodide in order to synthesize hormones that act on almost all tissues and are essential for normal growth metabolism. Low plasma levels of lead hypothyroidism, which is one the most common disorder humans not always satisfactorily treated by lifelong hormone replacement. Therefore, addition lack vitro tractable models study human development, differentiation maturation, functional organoids could pave way explore new therapeutic approaches. Here we report...
Partial volume effect is an important source of bias in PET images that can be lowered by accounting for the point spread function (PSF) scanner. We measured such a PSF various points clinical scanner and modelled it as product matrices acting image space, taking asymmetrical, shift-varying non-Gaussian character into account (AMP modelling), we integrated this accurate space modelling conventional list-mode OSEM algorithm (EM-AMP reconstruction). showed on one hand when sufficiently high...
Tristetraprolin (TTP, encoded by the Zfp36 gene) regulates mRNA stability of several important cytokines. Due to critical role this RNA-binding protein in control inflammation, TTP deficiency leads spontaneous development a complex inflammatory syndrome. So far, phenotype has been largely attributed dysregulated production TNF and IL‑23 myeloid cells, such as macrophages or DCs. Here, we generated mice with conditional deletion keratinocytes (Zfp36fl/flK14-Cre mice, referred herein Zfp36ΔEP...
Idiopathic pulmonary fibrosis is characterized by a progressive and irreversible respiratory failure. Validated noninvasive methods able to assess disease activity are essential for prognostic purposes as well the evaluation of emerging antifibrotic treatments.C57BL/6 mice were used in murine model induced an intratracheal instillation bleomycin (control instilled with saline solution). At different times after instillation, PET/CT (18)F-FDG- or (18)F-4-fluorobenzamido-N-ethylamino-maleimide...
Idiopathic pulmonary fibrosis (IPF) is characterized by a progressive and irreversible respiratory failure. Non-invasive markers of disease activity are essential for prognosis evaluation early response to anti-fibrotic treatments.The aims this study were determine whether fluorodeoxyglucose ([18F]-FDG) lung uptake reduced after initiation pirfenidone or nintedanib assess its possible use as prognostic factor.[18F]-FDG PET/CT was performed in IPF patients murine model fibrosis. PET/CTs at...
Abstract Objective The pre‐operative technique most routinely used to localize pathological parathyroid glands (PPG), prior minimal access surgery (MAS), relies on 99m Tc‐sestamibi (MIBI) scintigraphy. Positron emission tomography (PET) using the radiolabelled amino acid 11 C‐methionine as tracer agent offers a technological alternative PPG. In this study we evaluated sensitivity of PET/CT (MET‐PET/CT) for PPG detection and extent which MET‐PET/CT images may contribute planning surgical...
Preoperative molecular imaging is paramount to direct surgery in primary hyperparathyroidism (pHPT). We investigated the diagnostic performance of 18F-fluorocholine (18F-FCH) PET/CT compared with 11C-methionine (11C-MET) for localization hyperfunctioning parathyroid tissue patients pHPT and negative or inconclusive 99mTc-sestaMIBI (99mTc-MIBI) SPECT findings. Methods: Fifty-eight biochemical evidence 99mTc-MIBI findings were referred presurgical detection by 11C-MET 18F-FCH PET/CT. The...
Fibroblast activation protein-α (FAPα) is a marker of activated fibroblasts that can be selectively targeted by an inhibitor (FAPI) and visualised PET/CT imaging. We evaluated whether the measurement FAPα in bronchoalveolar lavage fluids (BALF) uptake FAPI could used as biomarkers fibrogenesis.The dynamics lung 18F-labeled ([18F]FAPI-74) was assessed bleomycin mouse model at various time points using different concentrations PET/CT. measured BALFs from these bleomycin-treated control mice....
We report what is to our knowledge the first clear-cut experimental evidence of reversibility modulational instability in dispersive Kerr media. It was possible perform this experiment with standard telecommunication fiber because we used a specially designed 550-ps square-pulse laser source based on two-wavelength configuration nonlinear optical loop mirror. Our observations demonstrate that due well-balanced and synchronous energy transfer among significant number spectral wave components....
Food sharing is vital for a large number of species, either solitary or social, and particular importance within highly integrated societies, such as in colonial organisms social insects. Nevertheless, the mechanisms that govern distribution food inside complex organizational system remain unknown. Using scintigraphy, method developed medical imaging, we were able to describe dynamics food-flow an ant colony. We monitored process radio-labelled sucrose solution nest Formica fusca. Our...
The most common idiopathic interstitial lung disease (ILD) is pulmonary fibrosis (IPF). It can be identified by the presence of usual pneumonia (UIP) via high-resolution computed tomography (HRCT) or with use a biopsy. We hypothesized that CT-based approach using handcrafted radiomics might able to identify IPF patients radiological histological UIP pattern from those an ILD normal lungs. A total 328 one center and two databases participated in this study. Each participant had their lungs...
Adult-derived human liver stem/progenitor cells (ADHLSCs) have the potential to alleviate injury. However, optimal delivery route and long-term biodistribution of ADHLSCs remain unclear. In this article, we used a triple fusion reporter system determine kinetic differences in following intrasplenic (IS) intrahepatic (IH) administration severe combined immunodeficiency/beige mice. were transduced with lentiviral vector expressing comprising renilla luciferase, monomeric red fluorescent...
Trastuzumab remains an important drug in the management of human epidermal growth factor receptor 2 (HER2) overexpressing breast cancer (BC). Several studies reported resistance mechanisms to trastuzumab, including impaired HER2-accessibility caused by mucin 4 (MUC4). Previously, we demonstrated increase Zirconium-89-radiolabeled-trastuzumab (89Zr-Trastuzumab) accumulation when MUC4-overexpressing BC-cells were challenged with mucolytic N-Acetylcysteine (NAC). Hereby, using same approach...
Recent works have demonstrated the added value of dynamic amino acid positron emission tomography (PET) for glioma grading and genotyping, biopsy targeting, recurrence diagnosis. However, most these studies are exclusively based on hand-crafted qualitative or semi-quantitative features extracted from mean time activity curve (TAC) within predefined volumes. Voxelwise PET data analysis could instead provide a better insight into intra-tumour heterogeneity gliomas. In this work, we investigate...
Adjusting the molecular size, valency and pharmacokinetics of drug conjugates are as many leverages to improve their therapeutic window, notably by affecting tumor penetration, renal clearance, short systemic exposure. In that regard, small tumor-targeting ligands gaining attention. this study, we demonstrate benefits Nanofitin alternative scaffolds (7 kDa) selective modules for generation conjugates, focusing on Nanofitins B10 D8 directed against EGFR. Owing size monovalent format, two...
We investigate the nonlinear propagation of two forward propagating modes coupled by a resonant traveling-wave grating, which is photoinduced illuminating an optical fiber with beat signal. This interaction, representative systems whose dispersion relation K=K(Omega) exhibits gap in momentum K, shows evidence localization mediated resonance solitons. The signature still (in grating frame) soliton grating-induced cancellation modal group-velocity mismatch.
We demonstrate a significant resolution enhancement beyond the conventional limit in multiphoton microscopy (MPM) using saturated excitation of fluorescence.Our technique achieves super-resolved imaging by temporally modulating laser-intensity and demodulating higher harmonics from fluorescence signal.The improvement lateral axial resolutions is measured on sample fluorescent microspheres.While third harmonic already provides an enhanced resolution, we show that further can be obtained with...