A5013907203- Cancer, Hypoxia, and Metabolism
- TGF-β signaling in diseases
- Advanced Proteomics Techniques and Applications
- Cancer Research and Treatments
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Advanced Glycation End Products research
- FOXO transcription factor regulation
- Pancreatic and Hepatic Oncology Research
- Glioma Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Colorectal Cancer Treatments and Studies
- Glutathione Transferases and Polymorphisms
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Heat shock proteins research
- Diet and metabolism studies
- Cancer Genomics and Diagnostics
- Wnt/β-catenin signaling in development and cancer
- Extracellular vesicles in disease
- Cancer Mechanisms and Therapy
- Medical Imaging Techniques and Applications
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
University of Liège
2015-2023
European Institute of Oncology
2021-2023
Metabolic reprogramming toward aerobic glycolysis unavoidably induces methylglyoxal (MG) formation in cancer cells. MG mediates the glycation of proteins to form advanced end products (AGEs). We have recently demonstrated that MG-induced AGEs are a common feature breast cancer. Little is known regarding impact MG-mediated carbonyl stress on tumor progression. Breast tumors with presented high nuclear YAP, key transcriptional co-activator regulating growth and invasion. Elevated levels...
Background Breast cancer is a leading malignancy affecting the female population worldwide. Most morbidity caused by metastases that remain incurable to date. TGF-β1 has been identified as key driving force behind metastatic breast cancer, with promising therapeutic implications. Methods and Findings Employing immunohistochemistry (IHC) analysis, we report, our knowledge for first time, asporin overexpressed in stroma of most human cancers not expressed normal tissue. In vitro, secreted...
Pancreatic ductal adenocarcinoma (PDAC) remains a deadly malignancy with no efficient therapy available up‐to‐date. Glycolysis is the main provider of energetic substrates to sustain cancer dissemination PDAC. Accordingly, altering glycolytic pathway foreseen as sound approach trigger pancreatic regression. Here, we show for first time that high transforming growth factor beta‐induced (TGFBI) expression in PDAC patients associated poor outcome. We demonstrate that, although usually secreted...
// Arnaud Blomme 1 , Karim Fahmy Olivier Peulen Brunella Costanza Marie Fontaine 2 Ingrid Struman Dominique Baiwir 3, 4 Edwin de Pauw 3 Marc Thiry 5 Akeila Bellahcène Vincent Castronovo 1, * Andrei Turtoi Metastasis Research Laboratory, GIGA Cancer, University of Liège, 4000, Belgium Molecular Angiogenesis Research, Laboratory Mass Spectrometry, Proteomics Facility, Cell Biology, Faculty Sciences, These authors have contributed equally to this work Correspondence to: Turtoi, email:...
Colorectal cancer (CRC) cells are traditionally considered unresponsive to TGFβ due mutations in the receptors and/or downstream signaling molecules. influences CRC only indirectly via stromal cells, such as cancer-associated fibroblasts. However, cell ability directly respond currently remains unexplored. This represents a missed opportunity for diagnostic and therapeutic interventions. Methods: We examined whether from primary liver metastases by inducing TGFβ-induced protein ig-h3 (TGFBI)...
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related death. Therapeutic options remain very limited and are based on classical chemotherapies. Energy metabolism reprogramming appears as an emerging hallmark cancer considered a therapeutic target with considerable potential. Myoferlin, ferlin family member protein overexpressed in PDAC, involved plasma membrane biology has tumor-promoting function. In continuity our previous studies, we investigated role...
Inhibiting LSD1 reduces glioblastoma tumor-initiating cell survival by impeding their ability to handle the stress through deregulation of ATF4.
Highlights•Glycolytic mutant KRAS display higher MGO stress than wild-type CRC cells•MGO is a potent inducer of AKT signaling in induces resistance to anti-EGFR therapy setting•Carnosine, an scavenger, sensitizes tumors therapySummaryThe use cetuximab anti-epidermal growth factor receptor (anti-EGFR) antibodies has opened the era targeted and personalized colorectal cancer (CRC). Poor response rates have been unequivocally shown are even observed majority tumors. Therefore, patient selection...
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies with an overall survival 5% and second cause death by cancer, mainly linked to its high metastatic aggressiveness. Accordingly, understanding mechanisms sustaining PDAC phenotype remains a priority. In this study, we generated used murine in vivo model select clones from human Panc-1 cell line that exhibit propensity seed metastasize into liver. We showed myoferlin, protein previously reported be overexpressed PDAC,...
Abstract Colon adenocarcinoma is the third most commonly diagnosed cancer and second deadliest one. Metabolic reprogramming, described as an emerging hallmark of malignant cells, includes predominant use glycolysis to produce energy. Recent studies demonstrated that mitochondrial electron transport chain inhibitor reduced colon tumour growth. Accumulating evidence show myoferlin, a member ferlin family, highly expressed in several types, where it acts promoter participates metabolic rewiring...
// Brunella Costanza 1, * , Andrei Turtoi Akeila Bellahcène 1 Touko Hirano 2 Olivier Peulen Arnaud Blomme Vincent Hennequière Eugene Mutijima 3 Jacques Boniver Marie-Alice Meuwis 4 Claire Josse 5 Benjamin Koopmansch Karin Segers Takehiko Yokobori 6 Karim Fahmy Marc Thiry 7 Carla Coimbra 8 Nancy Garbacki 9 Alain Colige Dominique Baiwir 10, 11 Bours Edouard Louis Detry Philippe Delvenne Masahiko Nishiyama 6, 12 and Castronovo Metastasis Research Laboratory, GIGA Cancer, University of Liège,...
Abstract Introduction Colorectal cancer remains a public health issue and most colon patients succumb to the development of metastases. Using specific protocol pressure-assisted interstitial fluid extrusion recover soluble biomarkers, we identified paladin as potential liver metastases biomarker. Methods shRNA gene knockdown, explored biological function in cells investigated phospho-proteome within cells. We successively applied vitro migration assays, vivo metastasis models...
The search for biomarkers able to detect and evaluate disease such as cancer at an early stage, or predict resistance response therapies, has been remains a major challenge. Despite very important progresses in all fields of omics technologies, the success discovery clinically valuable is surprisingly disappointing. Difficult mining secreted proteins biological fluids poses first hurdle, mainly because concentration interesting serum urine generally low. second key limitation field...
Abstract BACKGROUND Glioblastoma (GBM), the most common primary brain tumor in adults, remains incurable despite multimodal therapy. There is a pressing unmet medical need for new therapeutic strategies, especially because patients experience only short-term benefit after treatment and vast majority inevitably relapse. Adaptation to harsh microenvironmental conditions, including nutrient deprivation, proteostasis perturbation, hypoxia drug treatment, induce molecular metabolic changes...