A5032405251- Collagen: Extraction and Characterization
- Circadian rhythm and melatonin
- Bone health and osteoporosis research
- Advanced Proteomics Techniques and Applications
- Sleep and related disorders
- Biosensors and Analytical Detection
- Spaceflight effects on biology
- Neuroendocrine regulation and behavior
- Attachment and Relationship Dynamics
- Protease and Inhibitor Mechanisms
- Bone Metabolism and Diseases
- Cell Adhesion Molecules Research
- Advanced biosensing and bioanalysis techniques
- Receptor Mechanisms and Signaling
- Hormonal and reproductive studies
- Hemodynamic Monitoring and Therapy
- Pharmacological Effects and Assays
- Bone and Dental Protein Studies
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Sleep and Wakefulness Research
- Vitamin D Research Studies
- Bone health and treatments
- Evolutionary Psychology and Human Behavior
University of Liège
2019-2025
Centre Hospitalier Universitaire de Liège
2024
Oxytocin is a 9-amino acid peptide that serves as neuromodulator in the human central nervous system. This implicated regulation of diverse behaviors and plays significant role positive social interaction. Currently, oxytocin levels are measured using immunoassays. However, these methods have several limitations can lead to false results erroneous interpretation. Given remarkably low endogenous level plasma (low ng/L levels), we developed rigorously validated novel highly sensitive LC-MS/MS...
A growing body of literature describes the potential effects circadian disruption on human health. Indeed, psychiatric diseases, metabolic syndrome, and cancers may be linked to disturbance rhythm. Currently, best practice assess rhythm is measurement melatonin levels. Our goal was thus develop validate a highly sensitive LC-MS/MS method follow salivary levels throughout day night. reached lower limit measuring interval (LLMI) 0.8 pg/mL. To our knowledge, it most allowing quantitation in...
Immunocapture is now a well-established method for sample preparation prior to quantitation of peptides and proteins in complex matrices. This short review will give an overview some clinical applications immunocapture methods, as well protocols with without enzymatic digestion context. The advantages limitations both approaches are discussed detail. Challenges related the choice mass spectrometer also discussed. Top-down, middle-down, bottom-up Even though has its limitations, main...
Growing epidemiological evidence points toward an association between fragmented 24-h rest-activity cycles and cognition in the aged. Alterations circadian timing system might at least partially account for these observations. Here, we tested whether daytime rest (DTR) is associated with changes concomitant probability profiles, neurobehavioural outcomes healthy older adults. Sixty-three individuals (59-82 years) underwent field actigraphy monitoring, in-lab dim light melatonin onset...
ABSTRACT With an aging population, the increased interest in monitoring of skeletal diseases such as osteoporosis led to significant progress discovery and measurement bone turnover biomarkers since 2000s. Multiple markers derived from type I collagen, CTX, NTX, PINP, ICTP, have been developed. Extensive efforts devoted characterizing these molecules; however, their complex crosslinked structures posed analytical challenges, date, remain poorly characterized. Previous attempts at...