A5039147430- Vitamin D Research Studies
- Collagen: Extraction and Characterization
- Advanced biosensing and bioanalysis techniques
- Folate and B Vitamins Research
- Adrenal Hormones and Disorders
- Hormonal and reproductive studies
- Bone health and osteoporosis research
- Marine Bivalve and Aquaculture Studies
- Isotope Analysis in Ecology
- Pharmacological Effects and Assays
- Marine animal studies overview
- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Receptor Mechanisms and Signaling
- Renal function and acid-base balance
- Bone health and treatments
- Analytical Methods in Pharmaceuticals
- Acoustic Wave Resonator Technologies
- Pesticide Residue Analysis and Safety
- Sleep and related disorders
- Evolutionary Psychology and Human Behavior
- Advanced Proteomics Techniques and Applications
- Antibiotic Use and Resistance
- Biosensors and Analytical Detection
- Meta-analysis and systematic reviews
University of Liège
2017-2025
Centre Hospitalier Universitaire de Liège
2016-2024
Oxytocin is a 9-amino acid peptide that serves as neuromodulator in the human central nervous system. This implicated regulation of diverse behaviors and plays significant role positive social interaction. Currently, oxytocin levels are measured using immunoassays. However, these methods have several limitations can lead to false results erroneous interpretation. Given remarkably low endogenous level plasma (low ng/L levels), we developed rigorously validated novel highly sensitive LC-MS/MS...
Abstract Background Simultaneous measurement of 25(OH)D and 24,25(OH)2D is a new tool for predicting vitamin D deficiency allows evaluating CYP24A1 lack function. Interpretation should be performed according to levels ratio, called the metabolite ratio (VMR) has been proposed such purpose. Unfortunately, VMR can expressed in different ways cannot used if concentrations are undetectable. Here, we propose enzyme activity taking into consideration probability that normal population presents...
A growing body of literature describes the potential effects circadian disruption on human health. Indeed, psychiatric diseases, metabolic syndrome, and cancers may be linked to disturbance rhythm. Currently, best practice assess rhythm is measurement melatonin levels. Our goal was thus develop validate a highly sensitive LC-MS/MS method follow salivary levels throughout day night. reached lower limit measuring interval (LLMI) 0.8 pg/mL. To our knowledge, it most allowing quantitation in...
Immunocapture is now a well-established method for sample preparation prior to quantitation of peptides and proteins in complex matrices. This short review will give an overview some clinical applications immunocapture methods, as well protocols with without enzymatic digestion context. The advantages limitations both approaches are discussed detail. Challenges related the choice mass spectrometer also discussed. Top-down, middle-down, bottom-up Even though has its limitations, main...
Objectives: 25-Hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH) and bone alkaline phosphatase (BALP) are biomarkers of calcium/phosphate metabolism turnover. Although vitamin deficiency is a well-known cause secondary hyperparathyroidism, few studies have considered status when establishing reference ranges. In this study, we report PTH levels according to the BALP in large cohort 1200 children. Additionally, provide pediatric values 25(OH)D as well ranges.Methods: Serum samples from...
The exploration of the metabolites in degradation pathways vitamin D (VTD) has gained importance recent years and simultaneous quantitation twenty-five-hydroxy (25(OH)D) mass concentration together with 24,25-dihydroxyvitamin (24,25(OH)2D) been proposed as a newer approach to define VTD deficiency. Yet, no data are available on 24,25(OH)2D biological variation (BV). In this study, we evaluated 24,25(OH)2D's BV European Biological Variation Study (EuBIVAS) cohort samples determine if...
Intrinsic biogeochemical markers, such as stable isotope ratios of carbon, nitrogen and sulphur, are increasingly used to trace the trophic ecology marine top predators. However, insufficient knowledge fractionation processes in tissues continues hamper use these markers.We performed a controlled feeding experiment with eight juvenile hooded seals (Cystophora cristata) that were held on herring-based diet (Clupea harengus) for two years. Stable measured via ratio mass spectrometry three...
A stable isotope dilution liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed for the determination of 24,25-dihydroxyvitamin D<sub>3</sub> (24,25(OH)<sub>2</sub>D<sub>3</sub>) and 25-hydroxyvitamin D<sub>3</sub>/D<sub>2</sub> (25(OH)D<sub>3</sub>/D<sub>2</sub>) in human aqueous humor samples.