A5005847516- MicroRNA in disease regulation
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- Bone health and osteoporosis research
- Cancer-related gene regulation
- Nutrition and Health in Aging
- Vitamin D Research Studies
- Folate and B Vitamins Research
- Epigenetics and DNA Methylation
- Traumatic Brain Injury and Neurovascular Disturbances
- Thyroid Disorders and Treatments
- Hematological disorders and diagnostics
- Parathyroid Disorders and Treatments
- Hemodynamic Monitoring and Therapy
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Wnt/β-catenin signaling in development and cancer
- Growth Hormone and Insulin-like Growth Factors
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Peptidase Inhibition and Analysis
- Bone health and treatments
- GDF15 and Related Biomarkers
- RNA Interference and Gene Delivery
- Biomedical Research and Pathophysiology
- Amyotrophic Lateral Sclerosis Research
University of Liège
2013-2024
Centre Hospitalier Universitaire de Liège
2015-2024
Hospital de Sant Pau
2023
University of Rijeka
2023
University of Zagreb
2023
University of Gothenburg
2023
Clinique Saint-Joseph
2021-2022
Abstract Constitutive activation of EGFR- and NF-κB-dependent pathways is a hallmark cancer, yet signalling proteins that connect both oncogenic cascades are poorly characterized. Here we define KIAA1199 as BCL-3- p65-dependent gene in transformed keratinocytes. expression enhanced on human papillomavirus (HPV) infection aberrantly expressed clinical cases cervical (pre)neoplastic lesions. Mechanistically, binds Plexin A2 protects from Semaphorin 3A-mediated cell death by promoting EGFR...
Neurofilament light chain (NF-L) concentration is recognized to be modified in neurological diseases and traumatic brain injuries, but studies the normal aging population are lacking. It is, therefore, urgent identify influencing factors of NF-L population.We assessed sera a large cohort 409 community-dwelling adults aged over 65 years. We studied association between various physiological also with self-reported comorbidities or life-style habits.We showed that serum was tightly associated...
Tumor initiation in the intestine can rapidly occur from Lgr5+ crypt columnar stem cells. Dclk1 is a marker of differentiated Tuft cells and, when coexpressed with Lgr5, also marks intestinal cancer Here, we show that Elp3, catalytic subunit Elongator complex, required for Wnt-driven tumor and radiation-induced regeneration by maintaining subpool Lgr5+/Dclk1+/Sox9+ Elp3 deficiency dramatically delayed appearance Apc-mutated epithelia greatly prolonged mice survival without affecting normal...
Abstract Objectives To evaluate some confounding factors that influence the concentrations of S100 calcium binding protein B (S100B), glial fibrillary acidic (GFAP), and ubiquitin carboxyl-terminal hydrolase L-1 (UCH-L1) in older individuals. Indeed, recent guidelines have proposed combined use S100B “GFAP-UCH-L1” mTBI test to rule out mild traumatic brain injuries (mTBI). As adults are most at risk mTBI, it is particularly important understand those rule-out biomarkers aging population....
Recent estimates consider that Long COVID affects 400 million people worldwide, of which <10% recover after two years. Predictive biomarkers and effective therapies are urgently needed for the clinical management COVID. Neurological manifestations (poor memory, brain fog) frequent, while neurodamage neuroinflammatory markers UCHL1, GFAP NFL were found to be increased in some but not all cohorts. However, a direct link between major disease mechanisms, viral persistence coagulation...
The Elongator complex is composed of 6 subunits (Elp1-Elp6) and promotes RNAPII transcript elongation through histone acetylation in the nucleus as well tRNA modification cytoplasm. This acetyltransferase directly or indirectly regulates numerous biological processes ranging from exocytosis resistance to heat shock yeast cell migration neuronal differentiation higher eukaryotes. identity human ELP1 ELP4 has been reported but ELP5 ELP6 have remained uncharacterized. Here, we report that DERP6...
Abstract Background Simultaneous measurement of 25(OH)D and 24,25(OH)2D is a new tool for predicting vitamin D deficiency allows evaluating CYP24A1 lack function. Interpretation should be performed according to levels ratio, called the metabolite ratio (VMR) has been proposed such purpose. Unfortunately, VMR can expressed in different ways cannot used if concentrations are undetectable. Here, we propose enzyme activity taking into consideration probability that normal population presents...
Abstract Background As clinical tests, such as gait speed, require nervous system integrity to be performed properly, sarcopenia shares features with neurological diseases. Neurofilament light chains (NF-L) are now used a blood-biomarker of neuronal damage, and its expression might altered in sarcopenia. We aimed assess NF-L concentrations large cohort older individuals screened for Methods The SarcoPhAge is Belgian 534 community-dwelling adults an ongoing 10-year follow-up. Sarcopenia...
Constitutive Wnt signaling promotes intestinal cell proliferation, but signals from the tumor microenvironment are also required to support cancer development. The role that proteins play establish a has not been extensively studied. Therefore, we assessed of proinflammatory Ikk-related kinase Ikkε in Wnt-driven We found was activated tumors forming upon loss suppressor Apc Genetic ablation β-catenin-driven models reduced incidence and consequently extended survival. Mechanistically,...
Objectives: 25-Hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH) and bone alkaline phosphatase (BALP) are biomarkers of calcium/phosphate metabolism turnover. Although vitamin deficiency is a well-known cause secondary hyperparathyroidism, few studies have considered status when establishing reference ranges. In this study, we report PTH levels according to the BALP in large cohort 1200 children. Additionally, provide pediatric values 25(OH)D as well ranges.Methods: Serum samples from...
Abstract Objectives Indirect methods for the indirect estimation of reference intervals are increasingly being used, especially validation intervals, as they can be applied to routine patient data. In this study, we compare three statistically different verification and in eight laboratories distributed throughout Europe. Methods The RefLim method is a fast simple approach which calculates by extrapolating theoretical 95 % non-pathological values from central linear part quantile-quantile...
Abstract Objective To identify a microRNA signature associated to sarcopenia in community-dwelling older adults form the SarcoPhAge cohort. Methods In screening phase by next generation sequencing (NGS), we compared hsa-miRome expression of 18 subjects with (79.6 ± 6.8 years, 9 men) and 19 healthy without (77.1 6 at baseline. Thereafter, have selected eight candidate hsa-miRNAs according NGS results after critical assessment previous literature. validation real-time qPCR, then analyzed...
<b>Background:</b> COVID-19 is a public health emergency of international concern. Yet, the question post-infectious evolution patients in healing process remains uncertain. Krebs von den Lungen 6 (KL-6) high molecular weight mucin-like glycoprotein produced by type II pneumocytes and bronchial epithelial cells. Its production raised during lesions cellular regeneration. In infection, KL-6 serum levels could be interest for diagnosis, prognosis therapeutic response evaluation. <b>Aims...
Background: The vitamin D metabolite ratio (VMR) has recently been identified as a potentially better indicator of deficiency than 25-hydroxyvitamin (25(OH)D) alone. This study aims to validate these findings by demonstrating that VMR is more strongly correlated with parathyroid hormone (PTH) levels 25(OH)D and 24,25-dihydroxyvitamin (24,25(OH)2D). In addition, the investigates effective predictor mortality 24,25(OH)2D. Methods: SarcoPhAge cohort Belgian community-dwelling older adults....
Mild traumatic brain injury (mTBI) remains challenging to diagnose effectively in the emergency department. Abbott has developed "GFAP/UCH-L1" mTBI test, guide clinical decision perform a computed tomography (CT) head scan by ruling out presence of mTBI. We evaluated diagnostic accuracy test Greek cohort and established age-dependent cut-offs.