A5080089928- RNA modifications and cancer
- Cancer-related gene regulation
- Inflammasome and immune disorders
- Wnt/β-catenin signaling in development and cancer
- RNA Research and Splicing
- Adipokines, Inflammation, and Metabolic Diseases
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Fibroblast Growth Factor Research
- MicroRNA in disease regulation
- Natural Products and Biological Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Prostate Cancer Treatment and Research
- Cardiac Ischemia and Reperfusion
- Foot and Ankle Surgery
- Adipose Tissue and Metabolism
- Axon Guidance and Neuronal Signaling
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- Cardiac Imaging and Diagnostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Eosinophilic Esophagitis
- Adenosine and Purinergic Signaling
- Fatty Acid Research and Health
- Atherosclerosis and Cardiovascular Diseases
Zhongnan Hospital of Wuhan University
2025
Wuhan University
2025
University of Liège
2012-2023
Centre Hospitalier Universitaire de Liège
2023
Second Affiliated Hospital of Jilin University
2018
Abstract Constitutive activation of EGFR- and NF-κB-dependent pathways is a hallmark cancer, yet signalling proteins that connect both oncogenic cascades are poorly characterized. Here we define KIAA1199 as BCL-3- p65-dependent gene in transformed keratinocytes. expression enhanced on human papillomavirus (HPV) infection aberrantly expressed clinical cases cervical (pre)neoplastic lesions. Mechanistically, binds Plexin A2 protects from Semaphorin 3A-mediated cell death by promoting EGFR...
Tumor initiation in the intestine can rapidly occur from Lgr5+ crypt columnar stem cells. Dclk1 is a marker of differentiated Tuft cells and, when coexpressed with Lgr5, also marks intestinal cancer Here, we show that Elp3, catalytic subunit Elongator complex, required for Wnt-driven tumor and radiation-induced regeneration by maintaining subpool Lgr5+/Dclk1+/Sox9+ Elp3 deficiency dramatically delayed appearance Apc-mutated epithelia greatly prolonged mice survival without affecting normal...
The Elongator complex is composed of 6 subunits (Elp1-Elp6) and promotes RNAPII transcript elongation through histone acetylation in the nucleus as well tRNA modification cytoplasm. This acetyltransferase directly or indirectly regulates numerous biological processes ranging from exocytosis resistance to heat shock yeast cell migration neuronal differentiation higher eukaryotes. identity human ELP1 ELP4 has been reported but ELP5 ELP6 have remained uncharacterized. Here, we report that DERP6...
Abstract Prolonged cell survival occurs through the expression of specific protein isoforms generated by alternate splicing mRNA precursors in cancer cells. How regulates tumor development and resistance to targeted therapies remain poorly understood. Here we show that RNF113A, whose loss-of-function causes X-linked trichothiodystrophy, is overexpressed lung protects from Cisplatin-dependent death. RNF113A a RNA-binding which multiple candidates involved survival. deficiency triggers death...
Clinical evidence indicates that innate immune cells may contribute to acute coronary syndrome (ACS). Our prospective study aimed at investigating the association of neutrophil phenotypes with ACS. 108 patients were categorized into chronic stable artery disease (n = 37), unstable angina (UA) 19), Non-ST-Elevation Myocardial Infarction (NSTEMI) 25), and ST-Elevation (STEMI) 27). At time inclusion, blood subpopulations analysed by flow cytometry. Differential cell count plasma levels...
The study aimed to identify the pivotal genes and pathways involved in prostate cancer metastasis. Using expression profile dataset GSE7930, downloaded from Gene Expression Omnibus (GEO) database, differentially expressed (DEGs) between primary highly metastatic cell samples were screened, followed by functional analysis tumor associated (TAG) screening. Protein-protein interaction (PPI) network of DEGs was constructed module performed. pathway related evaluated PCR migra- tion ability cells...
Aims: Palmitic acid (PA) and oleic (OA) are two main dietary fatty acids. Dietary intake of PA has been associated with cardiovascular disease risk, the effect OA remains uncertain. Our study aimed to assess a short-term lard, as source OA, on aorta aortic valve. Methods Results: Rabbits were fed lard-enriched diets, containing either elevated levels or both compared chow diet. After 16 weeks each diet, calcification was observed in intima The extent did not differ between diets. In...
In addition to its potent antiplatelet activity, ticagrelor possesses antibacterial properties against gram-positive bacteria. We wondered whether the typical clinical dosage of could prevent development infective endocarditis caused by highly virulent Staphylococcus aureus. Ticagrelor prevented vegetation formation in a mouse model inflammation-induced endocarditis. The achieved patients under therapy altered bacterial toxin production and adherence on activated endothelial cells, thereby...
Dietary cholesterol and palmitic acid are risk factors for cardiovascular diseases (CVDs) affecting the arteries heart valves. The ionizing radiation that is frequently used as an anticancer treatment promotes CVD. specific pathophysiology of these distinct disease manifestations poorly understood. We, therefore, studied biological effects dietary lipids their cardiac irradiation on valves in rabbit models Cholesterol-enriched diet led to thickening aortic wall valve leaflets, immune cell...
Aims: Clinical evidence indicates that innate immune cells may contribute to the onset and outcome of acute coronary syndrome (ACS). Our prospective study aimed at analysing neutrophil phenotypes in ACS their role predicting 1-year major cardiovascular events.
 Methods: Blood were analysed by flow cytometry. Differential blood cell count plasma levels soluble markers recorded admission 6-month follow-up.
 Results: 108 patients categorized chronic stable artery disease (n=37),...