A5064517536- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Valve Diseases and Treatments
- Epigenetics and DNA Methylation
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Heart Failure Treatment and Management
- Cancer-related gene regulation
- Colorectal Cancer Treatments and Studies
- Immune Cell Function and Interaction
- Congenital gastrointestinal and neural anomalies
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- IL-33, ST2, and ILC Pathways
- RNA Research and Splicing
- Autophagy in Disease and Therapy
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- GDF15 and Related Biomarkers
- Gastrointestinal motility and disorders
Ludwig-Maximilians-Universität München
2016-2023
University of Liège
2012-2018
Génétique Animale et Biologie Intégrative
2012
Abstract Genotoxic colibactin-producing pks + Escherichia coli induce DNA double-strand breaks, mutations, and promote tumor development in mouse models of colorectal cancer (CRC). Colibactin’s distinct mutational signature is reflected human CRC, suggesting a causal link. Here, we investigate its transformation potential using organoids from primary murine colon epithelial cells. Organoids recovered short-term infection with E. show characteristics CRC cells, e.g., enhanced proliferation,...
Interaction between the gut microbiota and host starts immediately after birth with progressive colonization of sterile intestine. Our aim was to investigate interactions taking place in colonic epithelium first exposure microbiota. Germ-free (GF) rats were inoculated two different microbiotas: first, obtained from suckling rats, rich primocolonizing bacteria second, adult representative a mature Once transferred into GF these microbiotas evolved such that they converged, recapitulated...
Inflammation can contribute to tumor formation; however, markers that predict progression are still lacking. In the present study, well-established azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced mouse model of colitis-associated cancer was used analyze microRNA (miRNA) modulation accompanying inflammation-induced development and determine whether inflammation-triggered miRNA alterations affect expression genes or pathways involved in cancer. A microarray experiment performed...
Background: Over time, the chance of cure after diagnosis breast cancer has been increasing, as a consequence earlier diagnosis, improved diagnostic procedures and more effective treatment options.However, oncologists are concerned by risk long term side effects, including congestive heart failure (CHF).Methods: In this study, we evaluated innovative circulating cardiac biomarkers during anthracycline-based neoadjuvant chemotherapy (NAC) in patients.Levels cardiac-specific troponins T...
B-type natriuretic peptide (BNP) is often used as a complementary finding in the diagnostic work-up of patients with aortic stenosis (AS). Whether soluble ST2, new biomarker cardiac stretch, associated symptomatic status and outcome asymptomatic AS unknown. sST2 BNP levels were measured 86 (74±13 years; 59 asymptomatic, 69%) (<1.5 cm2) preserved left ventricular ejection fraction who followed-up for 26±16 months. Both NYHA class but (>23 ng/mL, AUC = 0.68, p<0.01) was more accurate to...
Tumor-associated hypoxia, i.e., decreased availability of oxygen, results in a poor clinical outcome since it promotes EMT, metastasis, and chemotherapy-resistance. We have previously identified p53 its target miR-34a, as critical determinants the effect hypoxia on colorectal cancer (CRC). Here, we aimed to characterize mechanisms that contribute selective advantage cells with loss p53/miR-34a function hypoxic environment. Using silico prediction, XBP-1 IRE1A potential miR-34a targets. are...
Background & AimsIntratumor heterogeneity is a common feature of colorectal cancer (CRC). Here, we analyzed whether mesenchymal-like CRC cells promote the progression epithelial-like via paracrine mechanisms.MethodsSix cell lines that show an epithelial phenotype were treated with conditioned media (CM) from mesenchymal phenotype, and effects on epithelial-mesenchymal transition (EMT), migration, invasion, chemoresistance determined. Secreted factors potentially mediating these identified by...
The CSF1 receptor (CSF1R) encoding mRNA represents a direct target of miR-34a.However, the in vivo relevance suppression CSF1R by miR-34a for intestinal tumor mediated p53/miR-34a pathway has remained unknown.Here, Apc Min/+ mice with intestinal-epithelial cell (IEC)-specific deletions Mir34a showed increased formation adenomas and decreased survival, whereas deletion Csf1r adenoma survival.In enhanced proliferation, STAT3 signaling, infiltration fibroblasts, immune cells microbes, stem...
Abstract Colorectal cancer is one of the most common cancers and a major cause mortality. Proinflammatory antitumor immune responses play critical roles in colitis-associated colon cancer. CCL17, chemokine C-C family ligand for CCR4, expressed by intestinal dendritic cells steady state upregulated during colitis mouse models inflammatory bowel disease patients. In this study, we investigated expression pattern functional relevance CCL17 tumor development using CCL17–enhanced GFP-knockin...
Increased incidence of obesity is a worrying issue; some epidemiological studies highlight the relationship between and all digestive functional disorders.The Aim: object our work to study prevalence irritable bowel syndrome (IBS) in population suffering from obesity. Materials Methods: this cross-sectional descriptive study. A clinical questionnaire on functionaldigestive disorders (based Rome IV criteria) was filled in, interesting obese people with BMI> 30 Kg / m² admitted for management...