A5037046702- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Xenotransplantation and immune response
- Organ Transplantation Techniques and Outcomes
- Animal Genetics and Reproduction
- T-cell and B-cell Immunology
- Chronic Lymphocytic Leukemia Research
- Tissue Engineering and Regenerative Medicine
- Complement system in diseases
- Renal Diseases and Glomerulopathies
- Drug-Induced Adverse Reactions
- Immunodeficiency and Autoimmune Disorders
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- Organ and Tissue Transplantation Research
- Lymphoma Diagnosis and Treatment
- Organ Donation and Transplantation
- Pneumocystis jirovecii pneumonia detection and treatment
- Heparin-Induced Thrombocytopenia and Thrombosis
- Immune Cell Function and Interaction
- Multiple Myeloma Research and Treatments
- Mechanical Circulatory Support Devices
- Calcium signaling and nucleotide metabolism
- Acute Lymphoblastic Leukemia research
- Cell death mechanisms and regulation
New York University
2023-2025
NYU Langone Health
2020-2025
Miami Transplant Institute
2021-2024
University of Pittsburgh Medical Center
2017-2024
Yale University
2023
University of Minnesota
2023
Washington University in St. Louis
2023
Winterthur Museum Garden and Library
2023
Angion (United States)
2023
University of Colorado System
2023
Xenografts from genetically modified pigs have become one of the most promising solutions to dearth human organs available for transplantation. The challenge in this model has been hyperacute rejection. To avoid this, bred with a knockout alpha-1,3-galactosyltransferase gene and subcapsular autologous thymic tissue.We transplanted kidneys these into two brain-dead recipients whose circulatory respiratory activity was maintained on ventilators duration study. We performed serial biopsies...
The XVI-th Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from 19th-23rd September 2022, as a joint meeting with the Canadian Society of Transplantation. In addition to key focus on impact microvascular inflammation and biopsy-based transcript analysis Classification, further sessions were devoted other aspects kidney transplant pathology, particular T cell-mediated rejection, activity chronicity indices, digital xenotransplantation, clinical trials, surrogate...
Xenotransplantation of genetically engineered porcine organs has the potential to address challenge organ donor shortage. Two cases porcine-to-human kidney xenotransplantation were performed, yet physiological effects on xenografts and recipients' immune responses remain largely uncharacterized.
We present this observational study of lung transplant recipients (LTR) treated with carfilzomib (CFZ)-based therapy for antibody-mediated rejection (AMR) the lung. Patients were considered responders to CFZ if complement-1q (C1q)-fixing ability their immunodominant (ID) donor-specific anti-human leukocyte antibody (DSA) was suppressed after treatment. Treatment consisted plus plasma exchange and immunoglobulins. Fourteen LTRs underwent 20 ID DSA AMR. Ten (71.4%) responded CFZ. IgG mean...
The impact of subclinical inflammation (SCI) noted on early kidney allograft biopsies remains unclear. This study evaluated the outcome SCI 3-month biopsy. A total 273/363 (75%) transplant recipients with a functioning underwent 3-months posttransplant. Among those stable function at 3 months, 200 that did not meet Banff criteria for acute rejection were identified. These Group I: No Inflammation (NI, n = 71) and II: Subclinical (SCI, 129). We differences in 24-months histology score...
Imlifidase is an IgG-cleaving endopeptidase conditionally approved in Europe for desensitization of highly sensitized patients before kidney transplantation. We present 5-y outcomes and donor-specific antibody (DSA) levels clinical trial participants from a single site who received imlifidase incompatible transplantation (NCT02790437). was administered up to 24 h living or deceased donor DSAs were monitored transplantation, at days 7 28, 5 y posttransplant. At y, 8 alive. One these had...
In vascularized composite allotransplantation, face transplantation stands as a transformative intervention for patients with severe facial disfigurement. Monitoring of graft rejection, however, remains critical challenge. This study aimed to investigate the role lymphocyte subsets in early detection and monitoring rejection transplantation. We conducted retrospective chart review 3 transplant recipients who underwent at our institution. Peripheral blood samples were analyzed multiple time...
Human leukocyte antigen (HLA) molecular mismatch is a powerful biomarker of rejection. Few studies have explored its use in assessing rejection risk heart transplant recipients. We tested the hypothesis that combination HLA Epitope Mismatch Algorithm (HLA-EMMA) and Predicted Indirectly Recognizable Epitopes (PIRCHE-II) algorithms can improve stratification pediatric Class I II genotyping were performed by next-generation sequencing on 274 recipient/donor pairs enrolled Clinical Trials Organ...
Clusterin, ubiquitously distributed in mammalians, was cloned and identified as the most potently induced gene during rat prostate involution following androgen deprivation. Also found to be involved many other patho-physiological processes, its biological significance is still controversial, particularly with regard apoptosis. We previously showed that transient over-expression of clusterin blocked cell cycle progression simian-virus-40-immortalized human epithelial lines PNT1A PNT2. show...
In Brief Background We investigated in vitro whether HLA highly sensitized patients with end-stage renal disease will be disadvantaged immunologically after a genetically engineered pig kidney transplant. Methods Blood was drawn from calculated panel-reactive antibody (cPRA) 99% to 100% (Gp1, n = 10) or cPRA 0% (Gp2, 12), and healthy volunteers (Gp3, 10). Serum IgM IgG binding measured (i) galactose-α1-3 galactose N-glycolylneuraminic acid glycans by enzyme-linked immunosorbent assay, (ii)...