A5053657151- Genetics and Neurodevelopmental Disorders
- Genomics and Rare Diseases
- Hemoglobinopathies and Related Disorders
- Renal Transplantation Outcomes and Treatments
- Blood groups and transfusion
- Transplantation: Methods and Outcomes
- Head and Neck Surgical Oncology
- Epilepsy research and treatment
- Xenotransplantation and immune response
- Gut microbiota and health
- Airway Management and Intubation Techniques
- CRISPR and Genetic Engineering
- Inflammatory Bowel Disease
- Platelet Disorders and Treatments
- Renal Diseases and Glomerulopathies
- HIV/AIDS drug development and treatment
- Molecular Biology Techniques and Applications
- Bone Tumor Diagnosis and Treatments
- Facial Trauma and Fracture Management
- Mycobacterium research and diagnosis
- Erythrocyte Function and Pathophysiology
- Oral and Maxillofacial Pathology
- T-cell and B-cell Immunology
- Machine Learning in Bioinformatics
- Oral microbiology and periodontitis research
University of Pennsylvania
2021-2024
New York University
2024
Penn Center for AIDS Research
2023
California University of Pennsylvania
2023
National Institutes of Health Clinical Center
2018-2021
National Cancer Institute
2017
Center for Cancer Research
2017
Kamineni Institute of Dental Sciences
2014-2016
BackgroundDuctal adenocarcinoma of the prostate is an aggressive subtype, with high rates biochemical recurrence and overall poor prognosis. It frequently found coincident conventional acinar adenocarcinoma. The genomic features driving evolution to its ductal histology biology associated prognosis remain unknown.ObjectiveTo characterize distinguishing from foci same patient.Design, setting, participantsTen patients cancer underwent prostatectomy. Laser microdissection was used separately...
Abstract Tacrolimus metabolism is heavily influenced by the CYP3A5 genotype, which varies widely among African Americans (AA). We aimed to assess performance of a published genotype‐informed tacrolimus dosing model in an independent set adult AA kidney transplant (KTx) recipients. genotypes were obtained for all KTx recipients (n = 232) from 2010 2019 who met inclusion criteria at single center Philadelphia, Pennsylvania, USA. Medical record data used calculate predicted clearance using...
Abstract Background Crohn’s diseases and ulcerative colitis, both of which are chronic immune-mediated disorders the gastrointestinal tract major contributors to overarching Inflammatory bowel diseases. It has become increasingly evident that pathological processes IBDs results from interactions between genetic environmental factors, can skew immune responses against normal intestinal flora. Methods The aim this study is assess analyze taxa diversity relative abundances in CD UC Saudi...
ABSTRACT Background Recent advances in xenotransplantation living and decedent humans using pig xenografts have laid promising groundwork towards future emergency use first human trials. Major obstacles remain though, including a lack of knowledge the genetic incompatibilities between donors recipients which may led to harmful immune responses against xenograft or dysregulation normal physiology. In 2022 two heart were transplanted into brain-dead decedents with minimized immunosuppression...
Abstract Background and objectives Next generation sequencing (NGS) has promising applications in transfusion medicine. Exome (ES) is increasingly used the clinical setting, blood group interpretation an additional value that could be extracted from existing data sets. We provide first release of open‐source software tailored for this purpose describe its validation with three systems. Materials methods The DTM‐Tools algorithm was designed to analyse 1018 ES NGS files ClinSeq ® cohort....
Ischemic stroke represents a significant societal burden across the globe. Rare high penetrant monogenic variants and less pathogenic common single nucleotide polymorphisms (SNPs) have been described as being associated with risk of diseases. Genetic studies in Saudi Arabian patients offer greater opportunity to detect rare mutations enriched these consanguineous populations. We performed whole exome sequencing on 387 ischemic subjects from hospital networks up 20,230 controls Human Genome...
Abstract Background Epilepsy, a serious chronic neurological condition effecting up to 100 million people globally, has clear genetic underpinnings including common and rare variants. In Saudi Arabia, the prevalence of epilepsy is high caused mainly by perinatal factors. No whole-exome sequencing (WES) studies have been performed date in Arabian cohorts. This offers unique opportunity for discovery variants impacting this disease as there rate consanguinity among large tribal pedigrees....
Abstract Background Epilepsy, a serious chronic neurological condition effecting up to 100 million people globally, has clear genetic underpinnings including common and rare variants. In Saudi Arabia the prevalence of epilepsy is high caused mainly by perinatal factors. No whole-exome sequencing (WES) studies have been performed date in Arabian Epilepsy cohorts. This offers unique opportunity for discovery variants impacting this disease as there rate consanguinity amongst large tribal...